Prevention Interventions for Opioid Use Disorder

Overseen By Carrie Bourque

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Michigan

Disqualifiers: Acute sexual assault, Cancer, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

1155 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of the study is to develop and test innovative interventions to prevent the development of opioid misuse and opioid use disorders among older adolescents and young adults (AYA; ages 16-30) who use opioids, which will be initiated from a health care visit in the emergency department and extended post discharge via a telehealth approach. This study will have significant impact by identifying optimal, cost-effective opioid prevention strategies to sustain outcomes among AYAs.

Research Team

Erin Bonar

Principal Investigator

University of Michigan

Maureen Walton, PhD

Principal Investigator

University of Michigan

Eligibility Criteria

This trial is for young people aged 16-30 who visit a Michigan Medicine emergency department, can communicate in English, and are able to consent. They must have used prescription opioids and have at least one risk factor like drug misuse or depression. Pregnant individuals, those with recent injection drug use, acute sexual assault victims, suicidal individuals, or current cancer patients are excluded.

Inclusion Criteria

Seeking care in Michigan Medicine emergency department (ED)

I am mentally capable of understanding and agreeing to participate.

I use prescription opioids and have at least one other risk factor or misuse opioids.

Exclusion Criteria

I am currently dealing with an acute sexual assault, feeling acutely suicidal, or am diagnosed with/receiving treatment for cancer.

You have used injection drugs in the past year.

Current pregnancy at baseline

Treatment Details

Interventions

• Brief intervention (BI)
• Enhanced Usual Care (EUC)
• Portal

Trial Overview The study tests prevention strategies for opioid misuse among older adolescents and young adults using brief interventions (BI), a portal system for follow-up care, and enhanced usual care (EUC). It aims to identify cost-effective methods that prevent the development of opioid use disorders after an emergency department visit.

Participant Groups

Group I: Enhanced Usual Care (EUC) then Portal Experimental Treatment 2 Interventions

EUC will be delivered at intake and the portal will occur for 4 weeks starting at intake.

Group II: Brief intervention (BI) then Portal Experimental Treatment 2 Interventions

The BI will be delivered at intake and the portal will occur for 4 weeks starting at intake.

Group III: Brief intervention (BI) then Enhanced Usual Care (EUC) Experimental Treatment 2 Interventions

The BI will be delivered at intake and EUC will be added 4 weeks later.

Group IV: Enhanced Usual Care (EUC) then EUC Active Control 1 Intervention

EUC will be delivered at intake and delivered again 4 weeks later.

Who Is Running the Clinical Trial?

University of Michigan

Lead Sponsor

Trials

1,891

Recruited

6,458,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+