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Prevention Interventions for Opioid Use Disorder

N/A
Waitlist Available
Led By Erin Bonar, PhD
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Medically & cognitively able to provide consent or assent
Prescription opioid use plus >=1 other risk factor (misuse positive for marijuana, other illicit drugs, other prescription drug misuse; binge drinking; depression or suicidality) or opioid misuse [prescription opioid misuse or illicit opioid use (e.g., heroin, fentanyl)]
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3, 6, and 12 months
Awards & highlights

Study Summary

This trial will develop and test interventions to prevent opioid misuse and addiction in young adults ages 16-30, initiated during an emergency department visit and continued post-discharge via telehealth.

Who is the study for?
This trial is for young people aged 16-30 who visit a Michigan Medicine emergency department, can communicate in English, and are able to consent. They must have used prescription opioids and have at least one risk factor like drug misuse or depression. Pregnant individuals, those with recent injection drug use, acute sexual assault victims, suicidal individuals, or current cancer patients are excluded.Check my eligibility
What is being tested?
The study tests prevention strategies for opioid misuse among older adolescents and young adults using brief interventions (BI), a portal system for follow-up care, and enhanced usual care (EUC). It aims to identify cost-effective methods that prevent the development of opioid use disorders after an emergency department visit.See study design
What are the potential side effects?
Since this trial focuses on preventive interventions rather than medications, it may not involve typical drug side effects. However, participants might experience discomfort during discussions about personal substance use or emotional distress related to intervention content.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am mentally capable of understanding and agreeing to participate.
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I use prescription opioids and have at least one other risk factor or misuse opioids.
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I am between 16 and 30 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3, 6, and 12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3, 6, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in opioid misuse
Secondary outcome measures
Change in days of opioid misuse
Change in impaired driving
Change in other drug and alcohol use
+2 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Enhanced Usual Care (EUC) then PortalExperimental Treatment2 Interventions
EUC will be delivered at intake and the portal will occur for 4 weeks starting at intake.
Group II: Brief intervention (BI) then PortalExperimental Treatment2 Interventions
The BI will be delivered at intake and the portal will occur for 4 weeks starting at intake.
Group III: Brief intervention (BI) then Enhanced Usual Care (EUC)Experimental Treatment2 Interventions
The BI will be delivered at intake and EUC will be added 4 weeks later.
Group IV: Enhanced Usual Care (EUC) then EUCActive Control1 Intervention
EUC will be delivered at intake and delivered again 4 weeks later.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Portal
2011
N/A
~100
Enhanced Usual Care (EUC)
2015
Completed Phase 1
~4280

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,782 Previous Clinical Trials
6,363,502 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,447 Previous Clinical Trials
2,592,911 Total Patients Enrolled
Erin Bonar, PhDPrincipal InvestigatorUniversity of Michigan
2 Previous Clinical Trials
1,700 Total Patients Enrolled

Media Library

Brief intervention (BI) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04550715 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are currently participating in this trial?

"Correct. Based on the information present in clinicaltrials.gov, this medical trial is currently recruiting. It was first announced on April 1st 2021 and its most recent update occurred July 12th 2022; 1280 participants are sought to be enrolled at a single site."

Answered by AI

Are there still vacancies available in this clinical research project?

"As indicated on the clinicaltrials.gov website, this trial is in search of participants and was first posted on April 1st 2021 with its most recent update being July 12th 2022."

Answered by AI

Is participation in this medical trial open to the public?

"This trial is seeking a cohort of 1280 adolescents and young adults between 16 and 30 years old who have engaged in opioid abuse. In order to be eligible, participants must meet the requisites detailed as follows: evidence of prescription opioid use combined with at least one other risk factor (such as illicit drug or alcohol misuse, depression or suicidal ideation); proof that they are currently receiving care in Michigan Medicine's emergency department; an age range of 16-30."

Answered by AI

Is the minimum age for participation in this clinical trial over 25 years old?

"This clinical trial is recruiting 16 to 30 year olds. There are 30 studies open for minors and 338 studies available for seniors aged 65 and over."

Answered by AI
~277 spots leftby Mar 2025