Lifestyle Changes for Weight Management
(ORF Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study aims to explore the association between Melanocortin-4 Receptor (MC4R) polymorphisms, eating habits, and social determinants of health in a heterogeneous adult population in Georgia, USA.
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 in Georgia, USA who are overweight or have obesity. Participants must have a BMI between 25.0 and 40 Kg/m2 or higher. It's not open to those outside the specified BMI range.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Genotyping and Participant Stratification
Genetic variation of the MC4R gene is assessed and participants are stratified into genotype-based intervention groups
Genotype-Informed Lifestyle Intervention
Participants undergo an 8-week personalized dietary and physical activity intervention based on their genotype
Follow-up
Participants are monitored for changes in body composition, dietary patterns, and physical activity
What Are the Treatments Tested in This Trial?
Interventions
- Diet and exercise
- Exercise
- Lifestyle Intervention
Trial Overview
The study investigates how genetics (specifically MC4R polymorphisms) and lifestyle factors like diet and exercise affect weight management in people with different levels of obesity.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Diet and exercise baseline
Find a Clinic Near You
Who Is Running the Clinical Trial?
Augusta University
Lead Sponsor
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