Lifestyle Changes for Weight Management
(ORF Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how genes, eating habits, and social factors might affect weight management. The goal is to understand why some people respond differently to diet and exercise changes. Participants will engage in diet and exercise programs to observe how these lifestyle changes impact their weight. Ideal participants are adults living in Georgia with a BMI of 25 or higher who seek to manage their weight. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on personalized weight management strategies.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that lifestyle changes like diet and exercise are safe for most people. Studies have found that exercise helps maintain a healthy weight and can lead to weight loss. For instance, doing aerobic exercise for at least 150 minutes a week can reduce waist size and body fat.
Eating a balanced diet is also crucial for these lifestyle changes. Some studies suggest that diet is the main factor in weight gain, but combining it with exercise yields the best results. Overall, these lifestyle changes are manageable for most people and carry a low risk of serious side effects.
For any health concerns, consulting a healthcare professional before starting a new diet or exercise plan is advisable.12345Why are researchers excited about this trial?
Researchers are excited about these lifestyle interventions for weight management because they focus on holistic changes rather than just quick fixes. Unlike standard treatments that might rely heavily on medications or surgery, these interventions aim to empower individuals by integrating diet and exercise into daily life. This approach not only targets weight loss but also promotes long-term health benefits through sustainable lifestyle changes. By emphasizing personalized lifestyle shifts, these treatments could offer a more comprehensive and lasting solution for managing weight effectively.
What evidence suggests that this trial's treatments could be effective for weight management?
Research has shown that diet and exercise can lead to significant weight loss. In this trial, participants will follow a diet and exercise regimen. One study found that eating smaller portions and exercising for about 175 minutes each week resulted in a 5% weight loss. Even just engaging in aerobic activities for 150 minutes a week can reduce waist size and body fat. Combining diet and exercise with behavioral changes, known as lifestyle interventions, has enabled many adults to lose a significant amount of weight in six months. Specifically, one study found that 26% of participants maintained a 10% weight loss for four years. These findings suggest that these methods effectively manage weight.24678
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 in Georgia, USA who are overweight or have obesity. Participants must have a BMI between 25.0 and 40 Kg/m2 or higher. It's not open to those outside the specified BMI range.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Genotyping and Participant Stratification
Genetic variation of the MC4R gene is assessed and participants are stratified into genotype-based intervention groups
Genotype-Informed Lifestyle Intervention
Participants undergo an 8-week personalized dietary and physical activity intervention based on their genotype
Follow-up
Participants are monitored for changes in body composition, dietary patterns, and physical activity
What Are the Treatments Tested in This Trial?
Interventions
- Diet and exercise
- Exercise
- Lifestyle Intervention
Trial Overview
The study investigates how genetics (specifically MC4R polymorphisms) and lifestyle factors like diet and exercise affect weight management in people with different levels of obesity.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Diet and exercise baseline
Find a Clinic Near You
Who Is Running the Clinical Trial?
Augusta University
Lead Sponsor
Citations
A systematic review on the effectiveness of diet and ...
The ADF participants achieved body weight change of mean -0.9% ± 0.6% in the low-weight-loss group, and -9.9% ± 1.1% in the high-weight-loss ...
A systematic review on the effectiveness of diet ...
A combination of intensive physical activity of about 175 min per week and a portion-controlled diet led to a more significant weight loss of 5%. Conclusion.
Aerobic Exercise and Weight Loss in Adults: A Systematic ...
Aerobic exercise at least 150 minutes per week was associated with clinically important reductions in waist circumference and measures of body fat.
Weight Loss in Short-Term Interventions for Physical ...
This meta-analysis of 14 RCTs found that interventions lasting 6 months or less were effective at achieving weight loss. Each study showed ...
The Relationship Between Weight Loss Outcomes and ...
Results: At 9-16 weeks, among the 11,252 participants, 2594 (23.05%) had stable weight, 6440 (57.23%) had moderate weight loss, and 2218 (19.71 ...
Exercise and Fitness Effect on Obesity - StatPearls - NCBI - NIH
Researchers have proposed that exercise is an important lifestyle measure to maintain a healthy weight. This review will cover the role of exercise in obesity ...
Diet, not lack of exercise, drives obesity, a new study finds
And that finding offers strong evidence that diet — not a lack of physical activity — is the major driver of weight gain and obesity in our ...
Obesity and overweight
Obesity and overweight fact sheet from WHO providing key facts and information on causes, health consequences, double burden of disease, ...
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