Ascorbic Acid for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how the body's blood pressure response, specifically sympathetic-vascular transduction, is affected in individuals with obesity and insulin resistance. Researchers are investigating whether reducing oxidative stress—an overabundance of harmful molecules—can manage this response using vitamin C infusions. Participants will receive either vitamin C or a placebo (saltwater infusion) to test the effects. The study seeks individuals who are obese, have insulin resistance, and are not currently taking certain heart-related medications. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important medical advancements.
Will I have to stop taking my current medications?
You will need to stop taking any vitamin C or E supplements or omega-3 fatty acids two weeks before the trial. If you are currently taking a statin or antihypertension medication, you cannot participate in the trial.
What prior data suggests that this method is safe for studying vascular sensitivity to MSNA?
Research has shown that vitamin C, or ascorbic acid, is generally safe for people. In studies, individuals with obesity who took vitamin C experienced small positive effects, and it was well-tolerated. Another study found that vitamin C can help prevent stress-related problems in overweight individuals. Overall, vitamin C is considered safe, but consulting a healthcare provider about any possible side effects is always important.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how sympathetic neural activity affects obesity in humans without hypertension. Unlike current treatments for obesity, which often focus on diet, exercise, or medications to reduce appetite or absorption, this approach investigates the role of the nervous system. By understanding this connection, researchers hope to uncover new pathways to manage obesity more effectively, potentially leading to innovative treatments that address the root causes rather than just the symptoms.
What evidence suggests that ascorbic acid might be an effective treatment for hypertension in obesity and insulin resistance?
Research has shown that oxidative stress, an excess of harmful molecules in the body, is linked to obesity and insulin resistance. Vitamin C, or Ascorbic Acid, reduces this stress. Some studies suggest that Vitamin C can help manage the body's stress response in overweight individuals, but the overall evidence for its effects on obesity remains limited. Vitamin C has also been linked to lower body weight and body mass index (BMI). While these findings are encouraging, they indicate that Vitamin C might assist with certain aspects of obesity and insulin resistance rather than cause major changes. Participants in this trial will receive Ascorbic Acid to further investigate these potential benefits.25678
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Randomization and Experimental
Participants are randomized to receive either ascorbic acid or placebo in a double-blind fashion
Experimental
Participants receive the alternative treatment (ascorbic acid or placebo) in a double-blind fashion
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Ascorbic Acid
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Kansas Medical Center
Lead Sponsor
Citations
Molecular Pharmacology of Vitamin C and Relevance ... - PMC
Randomized trials assessing the effect of vitamin C supplementation in patients with obesity have found modest or no overall improvements in ...
The association between vitamin C dietary intake and its ...
Higher vitamin C consumption was significantly associated with lower BMI. There were no significant differences in serum vitamin C levels between normal-weight ...
Vitamin C: A Review on its Role in the Management of ... - PMC
100% fruit juice consumers had lower BMI, body weight, waist circumference and HbA1c compared to non-consumers. 100% fruit juice consumers had a lower risk of ...
Ascorbic acid prevents stress-induced hypercoagulability ...
Ascorbic acid (AA) may contribute to restoring hemostatic balance after mental stress (MS) in overweight/obese adults.
Vitamin C – a scoping review for Nordic ...
The aim of this scoping review is to describe the totality of evidence for the role of vitamin C for health-related outcomes as a basis for setting and ...
A Systematized Review of the Relationship Between ...
Studies in children found that higher vitamin C intakes were associated with obesity. In an analysis of NHANES III data of 12–16-y-old boys and girls, boys who ...
Estimation of Vitamin C Intake Requirements Based on ...
Our estimates suggest that an additional intake of 10 mg vitamin C/day is required for every 10 kg increase in body weight to attain a comparable plasma ...
Estimation of Vitamin C Intake Requirements Based on ...
People with obesity will likely need even higher vitamin C intakes. As poor vitamin C status is associated with increased risk of several chronic diseases ...
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