Milk Nutrient Absorption for Nutrition
Trial Summary
Will I have to stop taking my current medications?
The trial requires participants to stop taking certain medications and supplements that could interfere with the study, such as multivitamins, vitamin D, and other dietary supplements. There is a specific 'washout' period (time without taking certain medications) of three weeks for multivitamins and three months for vitamin D supplements before starting the study.
What evidence supports the effectiveness of the treatment for improving nutrient absorption from milk?
Research shows that calcium and vitamin D, components of the treatment, can improve calcium absorption, which is important for bone health. Studies indicate that vitamin D enhances calcium absorption, and calcium from milk is readily absorbed, suggesting that the treatment may help improve nutrient absorption from milk.12345
Is the Milk Nutrient Absorption treatment generally safe for humans?
Research shows that calcium and vitamin D, which are part of the Milk Nutrient Absorption treatment, are generally safe for humans when taken in appropriate amounts. Calcium supplements can cause stomach issues, but serious problems like kidney stones are not commonly linked to them. Vitamin D helps with calcium absorption and is important for bone health.678910
How does the milk nutrient absorption treatment differ from other treatments for nutrient absorption?
This treatment is unique because it leverages the natural components of milk, such as lactose and casein, which enhance the absorption of important minerals like magnesium and calcium, unlike soy-based alternatives that may inhibit absorption. Additionally, milk's specific calcium forms and the presence of casein-phosphopeptide contribute to its superior bioavailability compared to other calcium sources.1112131415
What is the purpose of this trial?
Plant-based milk alternatives (PBMAs) are a popular alternative to cow's milk. The different types of PBMAs on the market shelf include almond, oat, soy, coconut, cashew, pea, hemp, and rice. Among these, PBMA made from almonds, oats and soy are the most popular in North America. Though PBMAs are designed to mimic cow's milk in terms of color, they often have a very different nutrition profile. In order to better substitute for cow's milk, PBMAs often have added vitamins and minerals, as well as added sugars and flavorings to improve flavor.This study will test how well certain nutrients (vitamin D, calcium, potassium, and magnesium) are absorbed by the body after intake of milk and PBMAs. Nutrient absorption will be measured using blood samples after short term intake (from 1 hours to 1 week) of almond, soy, and oat milk, and compare it to cow's milk. Participants in the study will avoid all fluid dairy products and vitamin-D supplemented foods for three weeks and then be asked to consume either almond, soy, oat, or cow's milk for one week.All participants will visit the Clinical Nutrition Research Center (CNRC) four times over the course of about one month. These visits include a screening and pre-study visit (1.5 hrs), a pick-up visit (30 min), one long study day visit (\~11 hours), and two shorter follow up study day visits (1 hr).
Research Team
Chelsea Preiss
Principal Investigator
Illinois Institute of Technology
Eligibility Criteria
Healthy adults with a BMI of 20-40 kg/m2 and weight ≥110 lbs, not on certain medications (like proton pump inhibitors or anti-inflammatory drugs), non-smokers, and not pregnant. Participants must avoid multivitamins and vitamin-D supplements for three weeks prior to the study, as well as vigorous activity, caffeine, and alcohol before visits.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-study
Participants learn how to participate in the trial and schedule their study visits
Treatment
Participants consume assigned milk or PBMA and undergo blood and urine sampling
Follow-up
Participants are monitored for nutrient absorption and safety after treatment
Treatment Details
Interventions
- Calcium
- Magnesium
- Potassium
- Vitamin D
Find a Clinic Near You
Who Is Running the Clinical Trial?
Clinical Nutrition Research Center, Illinois Institute of Technology
Lead Sponsor
Food and Drug Administration (FDA)
Collaborator