Choline Nutrition Education for Pregnancy
(PRECIOUS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Less than 10% of pregnant women consume adequate levels of choline, an essential nutrient for maternal lipid metabolism, placental efficiency, and fetal development. Most prenatal vitamins do not contain choline; a research survey shows that only 6% of OB/GYNs were likely to recommend choline-rich foods to pregnant women. Nutrition education grounded in the Health Belief Model (HBM) has high efficacy among pregnant women; therefore, it is likely that HBM-driven choline education intervention will increase maternal choline levels. No studies have evaluated the influence of prenatal choline education intervention on maternal, placental, and neonatal outcomes. Our preliminary data suggest that increased choline intake corresponds with lower maternal body fat percentage (BF%), infant 1-month BF%, and MSC lipid accumulation, as well as increased placental efficiency. The central hypothesis is that choline education will increase maternal choline levels and improve placental function and infant health. We will test this hypothesis with three aims: to determine the influence of choline education intervention on maternal choline intake, placental efficiency, and infant health at the whole-body and cellular levels. The proposed study will be the first to provide a critical translational understanding of the influence of prenatal choline education intervention on maternal, placental, and child health.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Choline Nutrition Education
Participants receive choline nutrition education between gestational weeks 16 through 36
Usual Care
Control group receives intervention materials at 36 weeks of gestation after completion of all 36-week measures
Follow-up
Participants are monitored for infant body composition and maternal outcomes post-intervention
What Are the Treatments Tested in This Trial?
Interventions
- Choline nutrition education (CNE)
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will receive choline nutrition education (CNE) between gestational weeks 16 through 36.
Usual care, control group. Participants will receive the intervention materials at 36 weeks of gestation after completion of all 36-wk measures.
Find a Clinic Near You
Who Is Running the Clinical Trial?
East Carolina University
Lead Sponsor
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