JADE101 for Healthy Volunteers

Overseen By Han

Age: 18 - 65

Sex: Any

Trial Phase: Phase 1

Sponsor: Jade Biosciences, Inc.

Disqualifiers: Alcohol use, Smoking, Drug abuse, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a Phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of JADE101 in healthy Japanese and Chinese participants.

Who Is on the Research Team?

Li Li, MD

Principal Investigator

Jade Biosciences

Are You a Good Fit for This Trial?

Inclusion Criteria

First-generation Japanese or Chinese participants born in Japan/China

Willing and able to comply with contraceptive and lifestyle requirements from admission through the end of the study

Willing and able to comply with the study site stay, scheduled visits, and study procedures

Exclusion Criteria

Harmful alcohol use

Smoking/vaping or heavy tobacco use within 2 years prior to screening

Known history of abuse of illicit drugs

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a single subcutaneous dose of JADE101

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety, tolerability, pharmacokinetics, and pharmacodynamics

48 weeks

Multiple visits (in-person and virtual)

What Are the Treatments Tested in This Trial?

Interventions

• JADE101

How Is the Trial Designed?

Group I: JADE101 Groups 3 and 4 Experimental Treatment 1 Intervention

Subcutaneous (SC) injection of JADE101

Group II: JADE101 Groups 1 and 2 Experimental Treatment 1 Intervention

Subcutaneous (SC) injection of JADE101

Who Is Running the Clinical Trial?

Jade Biosciences, Inc.

Lead Sponsor