← Back to Search

Behavioural Intervention

TMS for Neuropathic Pain

N/A

Recruiting

Led By Julian C Motzkin, MD/PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Stable on chronic pain medications for 4 weeks prior to the study and agreeable to continue throughout the study. These medications include: Tricyclic antidepressants (e.g., nortriptyline, amitriptyline), SNRIs (e.g., duloxetine, venlafaxine), gabapentinoids (e.g., gabapentin, pregabalin), antiepileptics (e.g., valproic acid, carbamazepine, lamotrigine), and daily anti-inflammatories (e.g., meloxicam), among others (as determined by study physician at the time of screening). Note: Medications that are known to increase cortical excitability (e.g., buproprion, maprotiline, tricyclic antidepressants, classical antipsychotics) or to have an inhibitory effect on brain excitability (e.g., antiepileptics, benzodiazepines, and atypical antipsychotics), or any other medications with relative hazard for use in TMS will be allowed upon review of medications and/or motor threshold determination by TMS specialist

"Pain caused by a lesion or disease of the somatosensory nervous system

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

Study Summary

This trial will evaluate whether non-invasive magnetic pulses to the brain can reduce chronic neuropathic pain, which is highly disabling and challenging to treat.

Who is the study for?

This trial is for adults aged 18-80 with chronic neuropathic pain lasting over 6 months due to nerve damage or disease. Participants must have a certain level of continuous pain, be able to tolerate the procedures, and give informed consent. They should be stable on their current pain medications and not pregnant, nursing, or have specific psychiatric conditions or contraindications for TMS.Check my eligibility

What is being tested?

The study tests high frequency rTMS versus low frequency rTMS as treatments for chronic neuropathic pain. It aims to determine if stimulating the brain's motor cortex can reduce pain by modulating brain activity without the side effects common in other treatments.See study design

What are the potential side effects?

rTMS may cause discomfort at the stimulation site, headache, lightheadedness, or seizures in rare cases. Some individuals might experience temporary hearing changes due to the noise during treatment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been on the same pain medication for 4 weeks and can continue during the study.

Select...

I have pain due to nerve damage or disease.

Select...

I experience ongoing pain in my face or limbs.

Select...

I am between 18 and 80 years old.

Select...

I understand and can agree to the study's procedures and risks.

Select...

My pain is due to nerve damage or disease.

Select...

I have been experiencing severe pain for more than 6 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Pain Intensity Over 2 weeks

Secondary outcome measures

Change in Beck Depression Inventory (BDI-II) Scores

Pain

Change in Pain Intensity Over 6 months

+4 more

Other outcome measures

Brain Network Assessment

Change Pittsburgh Sleep Quality Index (PSQI) Scores

Heart rate

+6 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: High Frequency rTMSExperimental Treatment1 Intervention

High frequency 10 Hz stimulation of motor cortex (M1)

Group II: Low Frequency rTMSActive Control1 Intervention

Low frequency 1 Hz stimulation of motor cortex (M1)

0 / 7Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor

2,505 Previous Clinical Trials

15,237,535 Total Patients Enrolled

2 Trials studying Neuropathic Pain

121 Patients Enrolled for Neuropathic Pain

Julian C Motzkin, MD/PhDPrincipal InvestigatorUniversity of California, San Francisco

Prasad Shirvalkar, MD/PHDPrincipal InvestigatorUniversity of California, San Francisco

Media Library

High Frequency rTMS (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05593237 — N/A

Neuropathic Pain Research Study Groups: High Frequency rTMS, Low Frequency rTMS

Neuropathic Pain Clinical Trial 2023: High Frequency rTMS Highlights & Side Effects. Trial Name: NCT05593237 — N/A

High Frequency rTMS (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05593237 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who qualifies for participation in this research study?

"In order to participate in this medical trial, applicants must have experienced nerve damage and be within the ages of 18-80. Altogether, 20 individuals are being enrolled for the study."

Answered by AI

Are there still opportunities to join this trial?

"As revealed by clinicaltrials.gov, this medical research project is no longer in search of study participants even though it was originally posted on November 1st 2022 and edited as recently as October 20th 2022. Fortunately there are still 1589 other trials actively recruiting patients at present."

Answered by AI

Is the age cutoff for participation in this study below 30 years old?

"To qualify for this trial, applicants must fall within the 18-80 year old age range. Additionally, there are 217 trials specifically recruiting minors and 1285 studies targeting seniors."

Answered by AI

Who else is applying?

What state do they live in?

Minnesota

Utah

Arizona

Other

What site did they apply to?

UCSF Medical Center

What portion of applicants met pre-screening criteria?

Did not meet criteria

Met criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

I HAVE CHIARI MALFORMATION/SYRINGOMYELIA ETC.I JUST RECENTLY JULY5TH HAD MY 3RD LAMINECTOMY/DECOMPRESSION SURGERY .I HAVE A SHUNT IN MY C4-C6 OF MY SPINE I HAVE SEVERE NEUROPATHY PAIN IM ON 20MG OPIOIDS /LYRICA 200MG ETC.AND DEAM OF THE DAY I CAN GET OFF AN IM WILLING TO TRAVEL TO THE ENDS OF THE EARTH FOR IT TO HAPPEN.

PatientReceived 1 prior treatment