Photoacoustic Imaging for Lymph Node Cancer

Overseen By Priya R. Bhosale

Age: 18+

Sex: Any

Trial Phase: Phase < 1

Sponsor: M.D. Anderson Cancer Center

Disqualifiers: Melanoma, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

23 Participants Needed

Trial Summary

What is the purpose of this trial?

This early phase I trial studies how well ultrasound-guided photoacoustic imaging works in telling the difference between healthy and cancerous inguinal (groin) lymph nodes and how well it can detect certain features of lymph nodes, including size and shape in patients with cancer. Ultrasound-guided photoacoustic is a non-invasive imaging method that can detect and display characteristics of lymph nodes based on the level of oxygen in the cells. This imaging method may provide more accurate tumor staging and prevent unnecessary surgical interventions.

Research Team

Priya R. Bhosale

Principal Investigator

M.D. Anderson Cancer Center

Eligibility Criteria

This trial is for cancer patients with suspicious groin lymph nodes identified by standard imaging and scheduled for needle aspiration or biopsy. It's not suitable for melanoma patients or those with deep (3-5 cm) or small (<1 cm) lymph nodes.

Inclusion Criteria

Suspicious inguinal lymph nodes for metastasis on a conventional imaging modality

I am scheduled for a needle biopsy guided by ultrasound.

My cancer diagnosis was confirmed through a biopsy.

Exclusion Criteria

My lymph nodes are not deep (3-5 cm) or small (<1 cm) enough to be excluded.

I have melanoma, which may affect test results due to its nature.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Imaging and Biopsy

Patients undergo standard of care ultrasound of the lymph nodes, then undergo ultrasound-guided photoacoustic imaging over 3-5 minutes, followed by standard of care ultrasound-guided fine needle aspiration or biopsy of a suspicious lymph node

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging and biopsy

3 months

Treatment Details

Interventions

• Fine-Needle Aspiration
• Lymph Node Biopsy
• Multispectral optoacoustic tomography (MSOT) acuity instrument
• Photoacoustic Imaging
• Ultrasound

Trial Overview The study tests ultrasound-guided photoacoustic imaging to distinguish between healthy and cancerous groin lymph nodes, aiming to improve tumor staging and reduce unnecessary surgeries.

Participant Groups

Group I: Diagnostic (ultrasound, ultrasound-guided PAI, FNA, biopsy) Experimental Treatment 5 Interventions

Patients undergo standard of care ultrasound of the lymph nodes, then undergo ultrasound-guided PAI over 3-5 minutes. Patients then undergo standard of care ultrasound-guided FNA or biopsy a suspicious lymph node.

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+