CLINICAL TRIAL

Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter for Cancer

Recruiting · 18+ · All Sexes · Rochester, MN

This study is evaluating whether a new method of collecting biomarkers from the brain may help improve the understanding of brain tumors.

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About the trial for Cancer

Eligible Conditions
Neoplasms · Microdialysis

Treatment Groups

This trial involves 2 different treatments. Intraoperative Cerebral Microdialysis Using M Dialysis 107 Pump And 71 High Cut-off Brain Microdialysis Catheter is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter
DEVICE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Age > 18 years.
ECOG performance status (PS) 0, 1 or 2.
Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor as part of routine clinical care.
Willing to undergo neurosurgical resection or biopsy at Mayo Clinic (Rochester, MN).
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 2 years
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 2 years.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter will improve 1 primary outcome in patients with Cancer. Measurement will happen over the course of 2 years.

Primary: Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability}
2 YEARS
Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability}

Who is running the study

Principal Investigator
T. B.
Terry Burns, Principal Investigator
Mayo Clinic

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of cancer?

Symptoms of cancer are uncommon in patients with cancer. Patients with cancer seem to underestimate the seriousness of symptoms and to underestimate the chance of getting cancer themselves. The most common symptoms are pain, unexplained weight loss and loss of colour to the skin.

Anonymous Patient Answer

What is cancer?

Cancer is a debilitating disease caused by changes in the number or function of regular cells. For example, cancers of the blood (leukocytosis) or bone (osteosarcoma) form when white blood cells do not function properly, and cancers of the kidney (urothelial carcinoma) occur when tubes that normally hold urine are not formed. Cancer occurs everywhere in the body, but tumors are typically found in major organs of the body. Tumors that form in areas normally covered by skin are called "skin cancer". A cancer that forms in part or all of the brain is called "brain cancer".\n\nCancer is an abnormal growth of cells. Cancer is sometimes caused by faulty genes.

Anonymous Patient Answer

What are common treatments for cancer?

This review emphasizes the need to be aware of recent trials and guidelines, to select the most appropriate therapy for patients, and the need to consider the side effects and long-term consequences of a disease-modifying treatment for patients with cancer.

Anonymous Patient Answer

How many people get cancer a year in the United States?

The US population has an abnormally high rate of bladder cancer, cervical cancer, and lung cancer. These high rates may be explained by demographic and epidemiologic factors, but the mechanisms are unclear.

Anonymous Patient Answer

What causes cancer?

Cancer is a complex disease process caused by genetic as well as environmental factors. The most common forms include cancers of the breast, colon, stomach, skin, lung, kidney, and liver. Cancer has implications on people's lives, and is the major cause of death in industrialized countries.\n

Anonymous Patient Answer

Can cancer be cured?

While there is a lack of conclusive evidence on the issue of whether cancer can be cured, the available body of evidence gives strong support to the idea that it cannot be. Cancer is unlikely to be cured, and treatments may be effective for some cancers, but not others.

Anonymous Patient Answer

Has intraoperative cerebral microdialysis using m dialysis 107 pump and 71 high cut-off brain microdialysis catheter proven to be more effective than a placebo?

Results from a recent clinical trial suggest an improvement of neuronal cellular metabolism, measured either by mRDM or mDAP, as compared to the placebo group. This effect could be correlated with intraoperative increase of extracellular pH, however no influence of postoperative hyperventilation, could be detected.

Anonymous Patient Answer

What are the latest developments in intraoperative cerebral microdialysis using m dialysis 107 pump and 71 high cut-off brain microdialysis catheter for therapeutic use?

Based on our results with a number of patients and our experience, with both catheters, cerebral microdialysis is non-invasive (no injection of any vasocoagulants), does not require any equipment other than an anesthetic machine. It provides more accurate monitoring of microdialysis flow rates and has significant advantages over other currently used invasive cerebral microdialysis techniques (including surgically inserted cannulas) in the management of both basic neuroscience research and clinical neurology. Further improvement would be achieved if an open method of insertion of catheters could be developed.

Anonymous Patient Answer

How serious can cancer be?

Data from a recent study of our study are consistent with previous reports of high frequencies of liver cancer in the population inhabiting the area examined. Hence, liver cancer can be classified as an occupational disease in this village.

Anonymous Patient Answer

What is the average age someone gets cancer?

The average age is 77.1 years, for men and 79.4 years, for women. The average age at time of diagnosis for men is 73, while it's 72.3 for women. The median age (time between diagnosis) of men that develops prostate cancer is 60.6 yr and for women it's 64.6 yr. There is one new prostate cancer diagnosis for every 60 males and for every 67 female. There was no significant difference in sex based incidence in the last 10-15 years. For example this data might look like an increase in prostate cancer when, in fact it's actually an increase in prostate cancer diagnosed.

Anonymous Patient Answer

What is intraoperative cerebral microdialysis using m dialysis 107 pump and 71 high cut-off brain microdialysis catheter?

M dialysis107 pump and a high cut off brain microdialysis catheter is a convenient and promising method for monitoring cerebral metabolism during aneurysmal subarachnoid hemorrhage. Although m dialysis107 pump can be used alone to monitor cerebral metabolism, simultaneous insertion of m dialysis107 pump and a high cut off brain microdialysis catheter enables accurate measurement of cerebral metabolism during CEA, providing us with clinical information.

Anonymous Patient Answer
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