Basic Science (microdialysis) for Glioblastoma

Mayo Clinic in Rochester, Rochester, MN
Targeting 7 different conditionsMicrodialysisN/ARecruitingLed by Terence C BurnsResearch Sponsored by Mayo Clinic

Study Summary

This trial is looking at a new way to collect information from people with brain tumors during surgery, in order to learn more about the safety and feasibility of the new method, as well as to gather data about potential biomarkers for brain tumors.

Eligible Conditions
  • Glioblastoma
  • Oligodendroglioma
  • Anaplastic Astrocytoma
  • Diffuse Astrocytoma
  • Brain Tumor
  • Brain Metastasis

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have a specific type of epilepsy that requires surgery to remove the problematic area in your brain, as determined by doctors and imaging tests.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 42 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 42 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incidence of adverse events
Targeted metabolomics
Secondary outcome measures
Microdialysate D-2HG
Necrotic core metabolites
Non-enhancing (FLAIR)- region metabolites
+1 more
Other outcome measures
Microdialysate oncometabolites

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Basic Science (microdialysis)Experimental Treatment1 Intervention
Patients undergo microdialysis over 30 minutes during standard of care biopsy or resection.
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Early Phase 1

Find a site

Who is running the clinical trial?

National Cancer Institute (NCI)NIH
13,369 Previous Clinical Trials
41,215,213 Total Patients Enrolled
309 Trials studying Glioblastoma
22,308 Patients Enrolled for Glioblastoma
Mayo ClinicLead Sponsor
3,048 Previous Clinical Trials
3,484,683 Total Patients Enrolled
14 Trials studying Glioblastoma
747 Patients Enrolled for Glioblastoma
Terence C BurnsPrincipal Investigator
Mayo Clinic in Rochester
4 Previous Clinical Trials
179 Total Patients Enrolled

Media Library

Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter (Device) Clinical Trial Eligibility Overview. Trial Name: NCT04047264 — N/A
Glioblastoma Research Study Groups: Basic Science (microdialysis)
Glioblastoma Clinical Trial 2023: Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter Highlights & Side Effects. Trial Name: NCT04047264 — N/A
Intraoperative cerebral microdialysis using M dialysis 107 pump and 71 High cut-off brain microdialysis catheter (Device) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04047264 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is geriatric participation accepted in this medical experiment?

"The terms of entry into this medical trial outline an age range for participants: a minimum of 18 and a maximum up to 89."

Answered by AI

Who qualifies to take part in this medical experiment?

"Eligibility for this research requires participants to have microdialysis and be between 18-89 years old. Approximately 52 individuals must sign up in order for the trial to proceed."

Answered by AI

Are there any vacancies open for participants in this clinical experiment?

"Affirmative. provides evidence that the search for trial participants is still active, with an initial posting date of January 1st 2020 and a recent update on November 11th 2022. This medical experimentation requires 52 individuals from one location to be enlisted."

Answered by AI

How many participants have enrolled in this research project?

"Affirmative. displays that this experiment is actively recruiting individuals, having been posted on the 1st of January 2020 and amended most recently on November 11th 2022. 52 patients are needed from just one medical centre to complete the study."

Answered by AI
~27 spots leftby Sep 2027