8000 Participants Needed

Study of Kidney Tumors in Younger Patients

Recruiting at 247 trial locations
Age: < 65
Sex: Any
Trial Phase: Academic
Sponsor: Children's Oncology Group
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This research trial studies kidney tumors in younger patients. Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in deoxyribonucleic acid (DNA) and identify biomarkers related to cancer.

Research Team

EA

Elizabeth A Mullen

Principal Investigator

Children's Oncology Group

Eligibility Criteria

Inclusion Criteria

Patients with the first occurrence of any tumor of the kidney identified on CT scan or MRI are eligible for this study; histologic diagnosis is not required prior to enrollment but is required for all patients once on study
Nephroblastic tumors
Nephroblastoma (Wilms' tumor) (favorable histology, anaplasia [diffuse, focal])
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Sample Collection and Analysis

Tumor tissue, blood, and urine samples are collected for research studies, including immunohistochemistry. CT scans and MRIs are also performed. Loss of heterozygosity analyses are performed by extraction of DNA.

Baseline

Follow-up

Participants are monitored periodically for 5 years to assess event-free survival and overall survival.

5 years

Treatment Details

Interventions

  • Cytology Specimen Collection Procedure
  • Laboratory Biomarker Analysis
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Ancillary-correlative (renal tumor classification, biology)Experimental Treatment2 Interventions
Tumor tissue, blood, and urine samples are collected for research studies, including immunohistochemistry. CT scans and MRIs are also performed. Loss of heterozygosity analyses (chromosome 1p and 16q) are performed by extraction of DNA. DNA polymorphisms are assayed by polymerase chain reaction using standard methodology. Leftover specimens are archived for future studies. (LOH and INI1 testing discontinued as of April 2014)

Find a Clinic Near You

Who Is Running the Clinical Trial?

Children's Oncology Group

Lead Sponsor

Trials
467
Recruited
241,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+
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