Postbiotic for Exercise Performance

(PBE Trial)

Overseen By Joesi M Krieger, MS

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Lindenwood University

Must not be taking: Antibiotics, Probiotics, Statins, Hypertension

Disqualifiers: Diabetes, Heart disease, Cancer, others

Compensation: Varies

Number of Visits: Unknown

Duration: 8 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial examines whether a special postbiotic blend, called Postbiotic Active Lifestyle Blend, can reduce exercise-induced stress and boost performance. Participants will take either this postbiotic supplement or a placebo that looks identical but contains no active ingredients. The trial targets healthy adults who exercise regularly, at least 2 to 5 times a week. Participants should not have significant ongoing medical issues or use antibiotics, probiotics, or nicotine products. As an unphased trial, it offers participants the opportunity to contribute to innovative research that could enhance exercise recovery and performance.

Will I have to stop taking my current medications?

The trial does not clearly state if you need to stop taking your current medications. However, if you have recently changed your dosage of certain medications like statins, hypertension, or psychiatric drugs, you may not be eligible to participate.

Is there any evidence suggesting that the Postbiotic Active Lifestyle Blend is safe?

Research has shown that postbiotics, such as the Postbiotic Active Lifestyle Blend, are generally safe for people. Postbiotics are products derived from heat-treated bacteria. They are considered safer than probiotics because they do not contain live bacteria, eliminating the risk of antibiotic resistance. Recent studies suggest that postbiotics can improve health without causing serious side effects.

While specific safety information for the Postbiotic Active Lifestyle Blend remains limited, the overall safety of postbiotics appears promising. They are easy to produce and typically have a long shelf life, enhancing their safety and usefulness. ^{1 2 3 4 5}

Why are researchers excited about this trial?

The Postbiotic Active Lifestyle Blend is unique because it leverages a heat-treated blend of bacterial strains to potentially enhance exercise performance. Unlike traditional supplements that often focus on nutrients or vitamins, this postbiotic approach targets the gut microbiome, which researchers believe could play a significant role in physical performance. By focusing on gut health, this treatment could offer a novel way to boost stamina and recovery, setting it apart from existing options like protein powders and energy drinks. Researchers are excited about its potential to optimize exercise outcomes through an innovative mechanism that complements the body's natural processes.

What evidence suggests that the Postbiotic Active Lifestyle Blend could be effective for exercise performance?

This trial will evaluate the effects of the Postbiotic Active Lifestyle Blend on exercise performance. Studies have shown that postbiotic supplements can enhance exercise performance. Early evidence suggests that postbiotics may reduce tiredness and boost readiness, which is crucial for athletes. Some research indicates they can improve mood and reduce stress-related issues like anxiety and depression during exercise. Additionally, postbiotics may help manage inflammation, which often occurs with intense physical activity. While research on humans is still developing, these initial findings suggest that postbiotics could support better exercise results. Participants in this trial will receive either the active Postbiotic Active Lifestyle Blend or a placebo. ^{1 3 6 7 8}

Who Is on the Research Team?

Chad M Kerksick, PhD

Principal Investigator

Lindenwood University

Are You a Good Fit for This Trial?

This trial is for healthy adults who regularly exercise. It's designed to see if a postbiotic blend can help with muscle pain and improve gut health after working out. People with chronic diseases, taking certain medications, or unable to commit to the study schedule are not eligible.

Inclusion Criteria

Signed informed consent

I am not currently being treated for any serious health issues, except those approved by the research team.

I agree to follow the study's rules and procedures.

Exclusion Criteria

Any condition or abnormality that, in the opinion of the investigator, would compromise participant safety or study data quality

Extensive travel (>1 month) that will disrupt the study protocol

Body mass index <18.5 to <29.9 kg/m2

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2 weeks

Treatment

Participants receive either the postbiotic blend or a placebo for 8 weeks to assess effects on oxidative stress and exercise performance

8 weeks

Baseline, mid-study, and post-intervention assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Postbiotic Active Lifestyle Blend

Trial Overview Participants will be randomly assigned to receive either a placebo or an active postbiotic blend. The study aims to determine if the postbiotic reduces oxidative stress and improves exercise performance in a double-blind setup where neither participants nor researchers know who receives what until the end.

How Is the Trial Designed?

Group I: Postbiotic Active Lifestyle Blend Experimental Treatment 1 Intervention

Participants in this arm will receive the active Postbiotic Active Lifestyle Blend supplement, which contains a heat-treated blend of bacterial strains

Group II: Placebo Placebo Group 1 Intervention

Participants in this arm will receive a placebo capsule that matches the appearance and dosage of the active blend.

Who Is Running the Clinical Trial?

Lindenwood University

Lead Sponsor

Trials

22

Recruited

830+

Archer Daniels Midland Co.

Industry Sponsor

Trials

3

Recruited

190+

Published Research Related to This Trial

A systematic review of 1,204 participants found that pre-, pro-, and syn-biotic supplements did not significantly improve gastrointestinal permeability or symptoms at rest or during exercise, indicating limited efficacy for these interventions.

While prebiotic supplementation increased certain beneficial gut bacteria and short-chain fatty acids, probiotics mainly boosted the specific strains given without affecting overall gastrointestinal health markers, suggesting a need for more comprehensive studies with validated biomarkers.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effect of prebiotics, probiotics, and synbiotics on gastrointestinal outcomes in healthy adults and active adults at rest and in response to exercise-A systematic literature review. Rauch, CE., Mika, AS., McCubbin, AJ., et al.[2022]

Citations

1. withpower.com withpower.com/trial/phase-myalgia-1-2025-96287

Postbiotic for Exercise Performance · Info for Participants What data supports the effectiveness of the treatment Postbiotic Active Lifestyle Blend for exercise performance? Research shows that certain probiotics and ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10933997/

It's Dead! Can Postbiotics Really Help Performance and ... Early evidence has provided some indication that postbiotic supplementation may help to support mood, reduce fatigue, and increase the readiness of athletes.

3. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/38474848/

It's Dead! Can Postbiotics Really Help Performance and ... Early evidence has provided some indication that postbiotic supplementation may help to support mood, reduce fatigue, and increase the readiness of athletes.

4. sciencedirect.com sciencedirect.com/science/article/pii/S1550413124000834

Unlocking the power of postbiotics: A revolutionary ... In this review, we provide a comprehensive summary of the latest research on postbiotics, emphasizing their positive impacts on both human and animal health.

5. frontiersin.org frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1572687/full

Probiotic supplementation for optimizing athletic performance The supplementation can reduce inflammatory process activity and stress-related factors, e.g., anxiety, depression, in intermittent exercise-associated sports.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8957944/

Best Practices for Probiotic Research in Athletic and ... Here we review current randomized controlled trials (RCTs) using probiotics for performance improvement, prevention of common illnesses, or general health.

7. clinicaltrials.gov clinicaltrials.gov/study/NCT06931977

Natural Product System and Lifestyle Modification This double-blind, repeated measures study will recruit healthy adults to determine efficacy, safety, anthropometric, microbiome, and epigenetic effects of ...

8. mdpi.com mdpi.com/2304-8158/13/18/2937

A Comprehensive Overview of Postbiotics with a Special ... Overall compared to probiotics, postbiotics are safer [12,13,14], generally possess a longer shelf life, are easily producible, pose no risk of antibiotic ...