PeptiStrong for Muscle Strength Enhancement

Overseen By Niamh Mohan, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Nuritas Ltd

Must not be taking: Muscle supplements, Metabolism drugs

Disqualifiers: Pregnancy, Diabetes, Cardiovascular, Cancer, others

Compensation: Varies

Number of Visits: 3

Duration: 8 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests PeptiStrong, a supplement made from fava beans, to determine if it boosts muscle strength and endurance when combined with an exercise program. Participants will receive either PeptiStrong or a placebo (a pill that looks identical but contains no active ingredients) for comparison. Ideal participants are healthy individuals aged 19 to 40 who have not engaged in regular intense exercise in the past six months and are willing to follow a specific exercise plan. As an unphased trial, this study allows participants to contribute to innovative research on muscle health and potentially experience improved strength and endurance.

Will I have to stop taking my current medications?

The trial does not specify if you must stop taking your current medications, but it does require you to maintain your current lifestyle habits, including medications, as much as possible. However, if you are taking medications that may affect muscle mass, strength, or metabolism, you may need to stop, as assessed by the study's qualified investigator.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that PeptiStrong is safe for humans. The FDA has approved it as GRAS (Generally Recognized as Safe), allowing its use in food at a dose of 2.4 grams per day, the same amount used in clinical trials. Studies have also found that PeptiStrong can improve strength and performance without causing significant side effects. This suggests that PeptiStrong is safe for use at the dose tested in clinical trials. ^{1 2 3 4 5}

Why are researchers excited about this trial?

PeptiStrong is unique because it harnesses the power of fava bean hydrolysate to enhance muscle strength. Unlike traditional treatments that might rely on synthetic compounds or injections, PeptiStrong is a natural supplement taken orally, offering a convenient and less invasive option. Researchers are excited about its potential to improve muscle strength with a simple daily regimen, potentially offering a new pathway for muscle health that stands apart from current treatments like protein powders or anabolic steroids.

What evidence suggests that PeptiStrong might be an effective treatment for enhancing muscle strength?

This trial will compare PeptiStrong, a supplement made from fava beans, with a placebo to evaluate its effects on muscle strength and endurance. Research has shown that PeptiStrong can significantly enhance muscle strength and endurance. In one study, participants taking PeptiStrong increased their strength by nearly 20% and improved their bone density by 1% in just 56 days. Another study found that PeptiStrong helped maintain muscle strength, accelerated recovery by 144%, and boosted athletic performance by 54%. It also reduced tiredness by 47%, making it a promising choice for those seeking to enhance physical performance and muscle recovery. These findings suggest PeptiStrong could effectively build muscle strength when used alongside exercise. ^{1 6 7 8 9}

Are You a Good Fit for This Trial?

This trial is for men and women aged 19-40 with a BMI of 18.5 to 29.9, who are willing to follow an exercise program three times a week without engaging in other vigorous activities two days before testing. Participants should maintain their current lifestyle, including diet and sleep patterns, avoid NSAIDs and alcohol before visits, and use contraception if necessary.

Inclusion Criteria

You have not gained or lost more than 5 kilograms of body weight in the past 3 months.

You agree not to take painkillers like ibuprofen and avoid drinking alcohol for a certain number of hours before each clinic visit.

You are willing to follow the exercise instructions based on the Self-motivation Questionnaire.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive PeptiStrong or placebo supplementation in conjunction with an exercise program for 56 days

8 weeks

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• PeptiStrong
• Placebo SMCC silicated micro-crystalline cellulose

Trial Overview The study tests PeptiStrong's effectiveness on muscle strength when combined with regular exercise compared to a placebo (an inactive substance). It's randomized (participants are assigned by chance) and double-blind (neither researchers nor participants know who gets what), ensuring unbiased results.

How Is the Trial Designed?

Group I: PeptiStrong - fava bean hydrolysate preparation Experimental Treatment 1 Intervention

PeptiStrong 2.4g/day will be supplemented as 5 capsules (480mg each) taken with approx. 150mL water at breakfast once per day for 56 days

Group II: Silicated micro-crystalline cellulose (SMCC) Placebo Group 1 Intervention

The placebo 2.4g/day will be supplemented as 5 capsules taken with approx. 150mL water at breakfast once per day for 56 days

Who Is Running the Clinical Trial?

Nuritas Ltd

Lead Sponsor

Trials

7

Recruited

400+

Published Research Related to This Trial

Supplementing compressed food with maltooligosaccharides (CFMO) significantly improved heart rate recovery and maintained higher blood glucose levels while reducing post-exercise blood lactate levels in soldiers during military training.

Soy oligopeptides (CFSO) also enhanced recovery by accelerating blood lactate clearance and increasing fluid retention, but did not show significant differences in muscle injury or perceived exertion compared to other diets.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Compressed food with added functional oligopeptides improves performance during military endurance training. Zheng, ZQ., Geng, ZH., Liu, JX., et al.[2019]

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT05946746

The Effects of PeptiStrong and Exercise to Enhance Muscle ... This study evaluates PeptiStrong's effect on muscle strength in young subjects, using 2.4g/day for 56 days with exercise, measuring leg extension 1RM.

2. nuritas.com nuritas.com/oral-muscle-peptide-ingredient-peptistrong-delivers-20-strength-gain-and-1-increase-bone-density-in-latest-clinical-trial-in-56-days/

Oral Muscle peptide ingredient, PeptiStrong® delivers 20% ... PeptiStrong® increased strength by 19.7% and bone density by 1% in 56 days, with a significant increase in endurance after 4 weeks.

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9967853/

Improved Strength Recovery and Reduced Fatigue with ... NPN_1 significantly improves strength recovery and restoration, reduces fatigue and positively modulates alterations in markers related to muscle homeostasis.

4. casi.org casi.org/trial-investigates-peptistrong-supplementation-muscle-strength-recovery-restoration

Randomized Controlled Trial Investigates PeptiStrong ... PeptiStrong™ maintained muscle strength, increased recovery by 144%, athletic performance by 54%, and reduced fatigue by 47% compared to ...

5. nuritas.com nuritas.com/revolutionary-muscle-health-ingredient-peptistrong-transforms-the-need-to-chase-more-protein/

Revolutionary Muscle Health Ingredient PeptiStrong ... Oral Muscle peptide ingredient, PeptiStrong® delivers 20% strength gain and 1% increase bone density in latest clinical trial in 56 days.

6. nuritas.com nuritas.com/peptistrong-receives-fda-gras-approval-for-food-applications/

PeptiStrong® Receives FDA GRAS Approval for Food ... The FDA's letter confirms that PeptiStrong® is safe for use at a level of 2.4g per serving across a broad range of popular food applications.

7. nuritas.com nuritas.com/deep-dive-into-peptistrong-an-ai-discovered-ingredient-for-muscle-health/

Deep Dive into PeptiStrong™: An AI Discovered Ingredient ... The pre-clinical and clinical studies conducted with PeptiStrong™ highlight how the signalling peptides within can impact strength, performance, ...

8. nutraceuticalbusinessreview.com nutraceuticalbusinessreview.com/nutritas-peptistrong-plant-based-protein-fda-gras-status

Nutritas' plant-based protein nutraceutical, PeptiStrong, ... The letter confirms that the muscle-supporting ingredient is safe for use at a dose of 2.4g per day in a number of different functional food and ...

9. nutraingredients.com nutraingredients.com/Article/2025/04/09/fava-bean-protein-hydrolysate-for-muscular-strength-and-endurance/

PeptiStrong study boost muscle strength, endurance and ... The dose used in the study corresponds to the dose listed in the company's GRAS (Generally Recognized as Safe) notification filed with the FDA.