Geranylgeraniol for Muscle Health

(GGE Trial)

Overseen By Anthony M Hagele, MS

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Lindenwood University

Must not be taking: Statins, Hypertension meds

Disqualifiers: Heart disease, Diabetes, Cancer, others

Compensation: Varies

Number of Visits: 5

Duration: 8 weeks

70 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will evaluate the effects of daily geranylgeraniol (GG) supplementation on muscular strength, body composition, and aerobic capacity in healthy, physically active men and women. Approximately 60 participants aged 30-60 years will be enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial lasting 8 weeks.

Participants will be assigned to receive either placebo, 150 mg GG, or 300 mg GG daily. Outcome measures will be assessed at baseline, week 4, and week 8 and include maximal strength (1RM bench press and leg press), fat-free mass, muscular endurance, aerobic capacity (VO2peak), and circulating biomarkers related to metabolism and health.

Who Is on the Research Team?

Chad M Kerksick, PhD

Principal Investigator

Lindenwood University

Are You a Good Fit for This Trial?

Inclusion Criteria

* Subject agrees to maintain their existing dietary patterns throughout the study period.

I agree not to have alcohol, caffeine, or exercise hard for 24 hours before each test.

* Is physically active, defined as at least 30 min of moderate exercise on at least 4 days a week.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

Treatment

Participants receive daily supplementation of either placebo, 150 mg GG, or 300 mg GG for 8 weeks

8 weeks

3 visits (in-person) at baseline, week 4, and week 8

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Geranylgeraniol

How Is the Trial Designed?

Group I: 300 mg Geranylgeraniol Active Control 1 Intervention

Participants will ingest 300 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.

Group II: 150 mg Geranylgeraniol Active Control 1 Intervention

Participants will ingest 150 mg of geranylgeraniol (GG) daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.

Group III: Placebo Comparator Placebo Group 1 Intervention

Participants will ingest a placebo consisting of olive oil daily for 8 weeks. The supplement will be consumed with approximately 8 ounces of water at a consistent time each day.

Who Is Running the Clinical Trial?

Lindenwood University

Lead Sponsor

Trials

22

Recruited

830+