Neuromuscular Electrical Stimulation for Obesity
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if electrical stimulation on muscles can counteract the negative effects of insufficient exercise. Participants will undergo neuromuscular electrical stimulation, which uses electrical impulses to stimulate muscle contractions, and their body's fat-burning ability will be tested after consuming a high-fat meal. This trial suits individuals who exercise regularly, can jog or run on a treadmill for at least an hour, and are willing to avoid caffeine and alcohol before study visits. As an unphased trial, it offers participants the opportunity to contribute to innovative research that could lead to new health insights.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are using medication for a heart or lung condition, you may not be eligible to participate.
What prior data suggests that neuromuscular electrical stimulation is safe for obesity?
Research shows that neuromuscular electrical stimulation (NMES) is generally safe. Studies have found it effective and safe for adults with belly fat. NMES has also proven safe and practical for patients with sudden heart failure, indicating it is well-tolerated by different groups.
No widespread reports of serious side effects from NMES have emerged in the reviewed studies. However, individual experiences can vary. Prospective participants in a clinical trial for NMES should consult their healthcare provider for personalized advice.12345Why are researchers excited about this trial?
Researchers are excited about neuromuscular electrical stimulation (NMES) for obesity because it offers a novel approach by using electrical impulses to stimulate muscle contractions, mimicking the effects of exercise without physical exertion. Unlike traditional methods like diet changes, medication, or physical exercise, NMES can potentially help individuals who are resistant or unable to engage in regular physical activity. This technique could enhance fat oxidation and improve metabolic health, making it a promising alternative or complement to existing obesity treatments.
What evidence suggests that neuromuscular electrical stimulation is effective for obesity?
Research has shown that neuromuscular electrical stimulation (NMES) could help manage obesity. In this trial, one arm will involve participants receiving NMES alongside treadmill exercise and limited walking. Studies have found that NMES might improve blood markers linked to insulin use, which is crucial for controlling weight and diabetes. In some cases, combining NMES with a healthy diet reduced body fat and waist size. NMES has also improved how the body handles sugar, especially in people who are overweight or obese. Overall, NMES offers a new approach to managing weight and related health issues.36789
Who Is on the Research Team?
Christopher Bell, Ph.D.
Principal Investigator
Colorado State University
Are You a Good Fit for This Trial?
This trial is for English-speaking individuals who are regularly active, can jog or run on a treadmill for at least an hour, and willing to avoid caffeine and alcohol before study visits. It's not suitable for those on heart/lung meds, breastfeeding, with exercise-limiting injuries, cardiopulmonary disorders, or if pregnant.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Establishing the normal benefit of exercise
Participants complete treadmill exercise and walk a minimum of 8,500 steps. Fat oxidation is measured the next day after a high-fat meal.
Demonstrating exercise resistance
Participants complete treadmill exercise and walk no more than 5,000 steps. Fat oxidation is measured the next day after a high-fat meal.
Trying to prevent exercise resistance
Participants complete treadmill exercise, walk no more than 5,000 steps, and receive 100 minutes of neuromuscular electrical stimulation. Fat oxidation is measured the next day after a high-fat meal.
Follow-up
Participants are monitored for safety and effectiveness after the interventions
What Are the Treatments Tested in This Trial?
Interventions
- Neuromuscular Electrical Stimulation
Trial Overview
The study tests whether 100 minutes of neuromuscular electrical stimulation can prevent the negative effects of not getting enough physical activity. Participants will receive muscle stimulation in a controlled setting.
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. They will receive 100 minutes of neuromuscular electrical stimulation. The next day, fat oxidation will be measured after eating a high-fat meal.
Study participants will complete treadmill exercise. During the same day, they will walk a minimum of 8,500 steps. The next day, fat oxidation will be measured after eating a high-fat meal.
Study participants will complete treadmill exercise. They will walk no more than 5,000 steps on the same day. The next day, fat oxidation will be measured after eating a high-fat meal.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Colorado State University
Lead Sponsor
Citations
Acute Feasibility of Neuromuscular Electrical Stimulation in ...
Furthermore, NMES training may improve blood markers of insulin sensitivity in diabetes mellitus and obesity [20, 21]. These studies collectively suggest a ...
Exercise, Nutrition, and Neuromuscular Electrical ...
In addition, NMES combined with nutritional supplementation showed better results in reducing body fat and waist circumference. However, nutritional ...
Neuromuscular Electrical Stimulation as A Diagnostic Tool ...
Our results indicated that the mean BMI value was significantly higher in class II obese women (36.78) compared to class I obese women (31.02) ...
Four weeks of electrical stimulation improves glucose ...
Conclusion: NMES is a novel and effective strategy to improve glucose tolerance in an at-risk overweight or obese sedentary population.
Effects of neuromuscular electrical stimulation on glycemic ...
Existing evidence suggested that NMES effectively improves glycemic control predominantly in middle-aged and elderly population with type 2 diabetes, obesity, ...
Effects of Electrical Muscle Stimulation on Waist ...
These findings suggest EMS is an effective, safe auxiliary treatment for abdominal obesity in adults. A larger scale clinical trial is needed to confirm the ...
7.
frontiersin.org
frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1344137/fullCase report of belt electrode-skeletal muscle electrical ...
NMES has been reported to be safe and feasible for patients with AHF (2). Recently, belt electrode skeletal muscle electrical stimulation (B-SES) ...
Neuromuscular electrical stimulation enhances glycemic ...
Neuromuscular electrical stimulation enhances glycemic control and carbohydrate utilization in sedentary, predominantly Hispanic overweight or ...
9.
clinicaltrials.gov
clinicaltrials.gov/study/NCT06722391?term=AREA%5BBasicSearch%5D(AREA%5BBasicSearch%5D(AREA%5BConditionSearch%5D(%22Insulin%20Resistance%22)))&rank=3Neuromuscular Electrical Stimulation: A Novel Treatment ...
Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.
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