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Gastric Bypass Surgery for Obesity

N/A
Waitlist Available
Led By Andrew Wheeler, MD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Planned laparoscopic Roux-en-Y gastric bypass
Age greater than 18
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 years
Awards & highlights

Study Summary

This trial will study how different modifications to the gastric bypass surgery affect molecular and metabolic changes in the body, in an effort to create targeted therapies for patients with morbid obesity.

Who is the study for?
This trial is for adults over 18 with severe obesity (BMI of 40-60 kg/m2) who are planning to undergo laparoscopic Roux-en-Y gastric bypass surgery and meet their insurance's criteria for weight loss surgery coverage. Participants must be willing to have blood tests, provide stool samples before and after the operation, and attend required follow-ups.Check my eligibility
What is being tested?
The study is testing how different lengths of intestine bypass (50 cm, 100 cm, or 150 cm) during gastric bypass surgery affect weight loss outcomes. It will also compare these surgeries with a sleeve gastrectomy group and a non-surgical therapy group while examining gut microbiome changes and hormone levels.See study design
What are the potential side effects?
Potential side effects may include typical risks associated with weight loss surgeries such as nutritional deficiencies due to malabsorption, surgical complications like infections or bleeding, gastrointestinal symptoms like nausea or vomiting, and changes in bowel habits.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am scheduled for a laparoscopic Roux-en-Y gastric bypass surgery.
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I am older than 18 years.
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My insurance covers weight loss surgery according to its policy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Complications after Variable Biliopancreatic Limb Length Bypass
Weight loss after Variable Biliopancreatic Limb Length Bypass
Secondary outcome measures
Gut enteroendocrine changes after Variable Biliopancreatic Limb Length Bypass
Gut microbiome changes after Variable Biliopancreatic Limb Length Bypass
MicroRNA expression after Variable Biliopancreatic Limb Length Bypass

Trial Design

3Treatment groups
Experimental Treatment
Group I: Standard BP limb lengthExperimental Treatment1 Intervention
50 cm BP limb length
Group II: Medium BP limb lengthExperimental Treatment1 Intervention
100 cm BP limb length
Group III: Long BP limb lengthExperimental Treatment1 Intervention
150 cm BP limb length

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
361 Previous Clinical Trials
627,244 Total Patients Enrolled
7 Trials studying Metabolic Syndrome
459 Patients Enrolled for Metabolic Syndrome
Andrew Wheeler, MDPrincipal InvestigatorUniversity of Missouri-Columbia, Department of Surgery
2 Previous Clinical Trials
390 Total Patients Enrolled
1 Trials studying Metabolic Syndrome
150 Patients Enrolled for Metabolic Syndrome

Media Library

100 cm BP limb length Clinical Trial Eligibility Overview. Trial Name: NCT04841057 — N/A
Metabolic Syndrome Research Study Groups: Long BP limb length, Standard BP limb length, Medium BP limb length
Metabolic Syndrome Clinical Trial 2023: 100 cm BP limb length Highlights & Side Effects. Trial Name: NCT04841057 — N/A
100 cm BP limb length 2023 Treatment Timeline for Medical Study. Trial Name: NCT04841057 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study accommodate participants of all ages, including those above eighty-five years?

"The eligibility requirements for this research project dictate that the age range is from 18 to 80. Moreover, there are 52 studies tailored towards minors and 506 for elderly individuals."

Answered by AI

Are enrollees being accepted in this clinical experiment currently?

"Clinicaltrials.gov reveals that this trial, which initially opened on November 1st 2021 and was last modified on March 24th 2022, is no longer actively seeking patients to enroll. Fortunately there are 649 other clinical trials searching for participants at the moment."

Answered by AI

What criteria make individuals ideal candidates for this clinical trial?

"This medical trial is enrolling 750 individuals aged 18 - 80 suffering from morbid obesity. To be eligible, patients must meet the requirements of their insurance policy for weight loss surgery and agree to have blood drawn pre- and postoperatively as well as collect and mail a stool sample before and after the procedure. Additionally, they should possess a body mass index between 40-60 kg/m2 with plans to undergo laparoscopic Roux-en-Y gastric bypass surgery."

Answered by AI

Who else is applying?

How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach
Andrew Wheeler 2021. "Biometabolic Outcomes After Weight Loss Surgery: An Individualized Approach". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04841057.
All > Fatty Liver Disease > Gastric Bypass
~500 spots leftby Mar 2031
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