Cognitive Behavioral Therapy for Suicide Prevention in Psychosis

Overseen By Lindsay A Bornheimer, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Michigan

Disqualifiers: Emergency care, Impaired capacity, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 14

Duration: 10 weeks

51 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial is testing a special therapy called CBSPp to help adults with schizophrenia who have had recent suicidal thoughts. The therapy aims to change harmful thoughts and behaviors to reduce the risk of suicide.

Are You a Good Fit for This Trial?

This trial is for English-speaking adults aged 18-65 with a schizophrenia spectrum disorder who have had suicidal thoughts or behaviors in the last 3 months. It's not suitable for those needing emergency care, with impaired cognitive capacity, or deemed inappropriate for behavioral treatment.

Inclusion Criteria

I have not had thoughts or attempts of suicide in the last 3 months.

Ability to speak and read in English

I have been diagnosed with a schizophrenia spectrum disorder.

Exclusion Criteria

I have difficulty with thinking or memory.

Requiring emergency care (e.g. imminent plan to harm self) as determined by trained research staff administering the Columbia-Suicide Severity Rating Scale (C-SSRS)

Deemed inappropriate for behavioral treatment according to own judgment in consultation with a treating clinician CMH

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

3 months

Treatment

Participants receive Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) in 10 weekly individual therapy sessions

10 weeks

10 visits (in-person)

Assessment

Quantitative assessments at baseline, 1-month, 3-months, and 5-months after baseline with in-depth qualitative interviews at 3-months

5 months

4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 months

What Are the Treatments Tested in This Trial?

Interventions

• Cognitive Behavioral Suicide Prevention for psychosis (CBSPp)
• Services as Usual (SAU)

Trial Overview The study tests Cognitive Behavioral Suicide Prevention tailored for psychosis (CBSPp) against standard services (SAU). Participants will be randomly assigned to one of these two groups and evaluated over five months through interviews and assessments.

How Is the Trial Designed?

Group I: Cognitive Behavioral Suicide Prevention for psychosis (treatment group) Experimental Treatment 1 Intervention

Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) is a behavioral treatment and will be delivered in 10 weekly individual therapy sessions in addition to standard/current services.

Group II: Services as Usual (SAU; comparison group) Active Control 1 Intervention

Services as usual involve standard and current services that clients are eligible for receiving.

Who Is Running the Clinical Trial?

University of Michigan

Lead Sponsor

Trials

1,891

Recruited

6,458,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials

3,007

Recruited

2,852,000+