Treatment for Memory Loss

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of California, Davis Alzheimer's Disease Center, Sacramento, CA
Memory Loss+2 More
Eligibility
65+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a set of activities can improve memory and thinking skills in older adults.

See full description

Eligible Conditions

  • Memory Loss
  • Cognitive Impairment (CI)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 8 primary outcomes and 14 secondary outcomes in patients with Memory Loss. Measurement will happen over the course of Change in assessment scores from baseline to 6-months, 12-months, and 18-months.

Change in assessment scores from baseline to 6-months, 12-months, and 18-months
Brief Resiliency Scale (BRS)
Center for Epidemiologic Studies Depression Scale (CES-D)
Community Healthy Activities Model Program for Seniors (CHAMPS)
Cooperative Study Activities of Daily Living (ADL) Prevention Instrument (ADCS-ADL-PI)
Coping Self efficacy (CSES)
Digit Span
Digit Symbol
Everyday Compensation (EComp)
Everyday Function
Free and Cued Selective Reminding Test (FCRT)
Logical Memory
Mindfulness Inventory
Patient Reported Outcomes Measurement Information System (PROMIS) General Health and Quality of Life Measure
Perceived Stress Scale (PSS)
Positive Affect and Negative Affect Scale (PANAS)
Purpose in Life
Royal Prince Alfred Prospective Memory Test
Satisfaction with Life
Short Physical Performance Battery
The Gratitude Questionnaire - Six Item Form
Trail Making
Verbal Fluency

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Structured Group
1 of 2
Self-Guided Group
1 of 2
Active Control

This trial requires 225 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Structured Group
Behavioral
Subjects in this group will will be provided with specific recommended behavior targets (e.g., like how much exercise you should engage in each week). Participants will also receive an iPad to use throughout the study and follow up period with the digital application installed. Subjects will be asked to use the digital application to record their activity and to receive reminders to complete this information. Two in every three participants will receive the iPad and digital application. Participants in this group will receive training on how to use the digital application. The researchers can install the digital application on the subjects' personal iPad or smartphone if they prefer.
Self-Guided Group
Behavioral
Subjects in this group will be provided education on memory support strategies and healthy lifestyles. Participants will decide how they want to implement this information into their daily lives. The study will also provide information on various commercially available digital and other tools that might help participants implement healthy changes their lives. One in every three participants will be enrolled in this group (selected randomly).

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: change in assessment scores from baseline to 6-months, 12-months, and 18-months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly change in assessment scores from baseline to 6-months, 12-months, and 18-months for reporting.

Closest Location

University of California, Davis Alzheimer's Disease Center - Sacramento, CA

Eligibility Criteria

This trial is for patients born any sex aged 65 and older. There are 8 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
a positive complaint in response to the question: 'Have you experienced a decline in your memory or other aspect of thinking in the last 1-3 years that seems worse than others of your age'
normal cognition on the modified Telephone Interview of Cognitive Status (mTICS)
independent function in daily life.
Age 65 or older
English speaking
Lower level of engagement in healthy lifestyle behaviors and compensation use at study baseline (i.e., broadly defined as not a regular exerciser)
Approval from primary care (due to physical exercise component of the intervention)
Open to utilizing digital tools such as a digital calendar in daily life

Patient Q&A Section

What is memory loss?

"Results from a recent paper found that depression, as indicated by poorer sleep quality, greater self-criticism and increased worry was associated with impaired recall performance on verbal and visuospatial episodic memory tasks. It concluded that memory impairment in depression occurs more than just affecting one sub-executive cognitive function. Sleep quality, self-criticism, worry and depression severity were significant factors in regards to recall performance and recall performance was significantly related to memory performance. This emphasizes the importance of screening for memory loss in depressed patients with a depressive episode. Cognitive deficits in depression can be addressed through different treatments, including the use of antidepressants." - Anonymous Online Contributor

Unverified Answer

What causes memory loss?

"This article presents the history, causes of and treatment of memory problems. It reviews the clinical and research evidence from relevant literature. It discusses treatment options based on current knowledge and professional treatment guidelines.\n" - Anonymous Online Contributor

Unverified Answer

Can memory loss be cured?

"The ability to learn new information and keep it remembered over time is reliant on the ability to encode new information and, in the short term, to retain the information already encoded. When the ability to encode and/or retain knowledge is compromised by injury or disease, this cognitive function cannot be restored." - Anonymous Online Contributor

Unverified Answer

What are the signs of memory loss?

"Memory loss is a common complaint in the primary care setting. The diagnosis of memory loss is a challenging clinical problem for primary care practitioners. In general, the primary care practitioner must be aware that a patient with memory impairment is likely to have a significant underlying medical, psychological, or social issue. Although memory loss is sometimes described as a gradual process, the symptoms may be episodic or sudden in onset. The first criterion for memory loss (or amnesis) is, by definition, a complaint (without proof of objective loss of memory from a comprehensive neurological examination)." - Anonymous Online Contributor

Unverified Answer

How many people get memory loss a year in the United States?

"Memory loss among elderly people is a growing issue. To support and enhance older adults' capacity for physical and mental health in daily activities, memory-enriching strategies need to be developed and implemented with elderly people in the healthcare system." - Anonymous Online Contributor

Unverified Answer

What are common treatments for memory loss?

"A variety of common treatment options are used for the prevention or treatment of cognitive symptoms experienced by individuals with a diagnosis of a primary memory disorder. A large percentage of cases can be remedied through the administration of pharmacological treatments, particularly stimulant medications (cognitive performance enhancing stimulants), and in some cases, a cognitive training and rehabilitation program (e.g., cognitive behavioural therapy (CBT), pharmacotherapy, etc.). The choice of intervention method can also depend on individual patient characteristics. For many individuals with a primary memory disorder, no treatment for their memory difficulties is available." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"There was no statistically significant difference in mean difference scores in recall from the three methods. The number of items recalled did not appear to be influenced by the technique used, but the number who forgot an item did appear to be influenced by the technique used." - Anonymous Online Contributor

Unverified Answer

How does treatment work?

"The authors suggest that memory treatment improves patient outcomes by helping patients and their families accept their treatment, deal with painful cancer treatments and adverse events, and live better lives after treatment is complete. A more complete and longer follow-up will be needed to determine sustained clinical benefit." - Anonymous Online Contributor

Unverified Answer

Has treatment proven to be more effective than a placebo?

"There is no clear evidence that the addition of a proinflammatory immune stimulant to antirentroviral therapy improves CD4+ T-cell recovery despite similar viral load suppression and improvement in memory T-cell reconstitution." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets memory loss?

"It is usually around 60-65 years of age. A person may develop symptoms as early as ages 41-47; however, if symptoms are present and the person is not wearing any corrective lenses, the first visit for memory loss is usually due to hearing impairment rather than Alzheimer's.\n" - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"Nearly all patients used the same combination of treatment as they did when initially diagnosed with dementia. Almost all patients who were diagnosed with dementia at the time they were receiving care at a residential memory care facility also received that care later. This suggests that clinicians often do not specify the treatment they use in patients they treated in the earlier period." - Anonymous Online Contributor

Unverified Answer

Is treatment safe for people?

"Most people can safely start on HD for 3-6 months. Most people who start on HD gain weight, and gain weight more slowly than those who continue to take DMZ. There are rare adverse effects, but they are uncommon and generally disappear after 4 months-5 years." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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