Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition
(HSR Trial)
Trial Summary
What is the purpose of this trial?
To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of the nap, and brain structure and function (using Magnetic Resonance Imagining or MRI). Additionally, overnight sleep physiology will be assessed in all participants. Waves will take place approximately every 6 months. For all children, three waves will be collected. With these data, the researchers will address the following aims:* Examine neural markers that predict the sleep transition (Aim 1);* Examine changes in sleep-dependent memory processing (mnemonic discrimination) over both nap and overnight sleep intervals, across the sleep transition (Aim 2);* Examine changes in sleep microstructure in both nap and overnight sleep across the sleep transition (Aim 3)* Examine interrelations among brain, memory and sleep microstructure across the sleep transition (Aim 4)
Eligibility Criteria
Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Wave 1
Participants complete nap or wake promotion sessions, memory assessments, and an MRI scan
Wave 2
Repeat of Wave 1 procedures including nap/wake sessions, memory assessments, and MRI scan
Wave 3
Final repeat of procedures including nap/wake sessions, memory assessments, and MRI scan
Follow-up
Participants are monitored for any long-term effects and data collection is finalized
Treatment Details
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Who Is Running the Clinical Trial?
University of Maryland, College Park
Lead Sponsor
University of Massachusetts, Amherst
Collaborator