180 Participants Needed

Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition

(HSR Trial)

Recruiting at 1 trial location
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of the nap, and brain structure and function (using Magnetic Resonance Imagining or MRI). Additionally, overnight sleep physiology will be assessed in all participants. Waves will take place approximately every 6 months. For all children, three waves will be collected. With these data, the researchers will address the following aims:* Examine neural markers that predict the sleep transition (Aim 1);* Examine changes in sleep-dependent memory processing (mnemonic discrimination) over both nap and overnight sleep intervals, across the sleep transition (Aim 2);* Examine changes in sleep microstructure in both nap and overnight sleep across the sleep transition (Aim 3)* Examine interrelations among brain, memory and sleep microstructure across the sleep transition (Aim 4)

Eligibility Criteria

Inclusion Criteria

I am between 3 and 5 years old.
I nap almost every day.
I sleep alone to ensure my sleep isn't interrupted.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Wave 1

Participants complete nap or wake promotion sessions, memory assessments, and an MRI scan

3-7 days
3 sessions (in-person)

Wave 2

Repeat of Wave 1 procedures including nap/wake sessions, memory assessments, and MRI scan

6 months after Wave 1
3 sessions (in-person)

Wave 3

Final repeat of procedures including nap/wake sessions, memory assessments, and MRI scan

6 months after Wave 2
3 sessions (in-person)

Follow-up

Participants are monitored for any long-term effects and data collection is finalized

4 weeks

Treatment Details

Participant Groups
1Treatment groups
Experimental Treatment
Group I: NapExperimental Treatment1 Intervention
Children are nap promoted

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Maryland, College Park

Lead Sponsor

Trials
163
Recruited
46,800+

University of Massachusetts, Amherst

Collaborator

Trials
83
Recruited
3,474,000+
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