Contingency Management for Cannabis Use Disorder

(ACT Trial)

Overseen By Katherine LeFevre, BS

Age: < 18

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Fetal alcohol spectrum, Autism, Psychosis, Neurological problems, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 13

Duration: 10 weeks

80 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.

Are You a Good Fit for This Trial?

This trial is for teens aged 14-17 who are trying to reduce their cannabis use. They'll need to participate in brain scans and attend virtual sessions for reporting usage and completing drug tests at home. Rewards are offered for staying cannabis-free.

Inclusion Criteria

I am between 14 and 17 years old.

Youth is MRI-eligible: No metal implants, prosthetics, orthodontic devices, transdermal medication patches, piercings and/or hair or eyelash extensions that cannot easily be removed, metallic ink tattoos on the neck or face, or claustrophobia, and are not pregnant

Youth must endorse having used cannabis at least once per week over the past month

Exclusion Criteria

Youth or caretaker who is monolingual non-English speaker

Youth who is currently undergoing contingency management treatment for cannabis use disorder

My child has a developmental, intellectual, or neurological condition.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

Baseline Assessment

Participants undergo an fMRI scan and perform an instrumental learning task

1 week

1 visit (in-person)

Treatment

Participants engage in ten weekly virtual contingency management sessions

10 weeks

10 visits (virtual)

Follow-up

Participants are monitored for cannabis use disorder symptoms and readiness to change

1 week

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Contingency Management

Trial Overview

The study is examining if brain activity related to learning can predict the success of a treatment program aimed at decreasing cannabis use among adolescents through Contingency Management therapy.

How Is the Trial Designed?

Group I: Contingency Management and Elastic Net Regression Experimental Treatment 2 Interventions

All participants will receive Contingency Management treatment for Cannabis Use. An elastic net regression model will be applied to the neuroimaging data for all participants to estimate scores on the CUDIT.

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+