70 Participants Needed

Exercise Training for Blood Cancers Survivorship

(S-POP Trial)

LH
AB
Overseen ByAmy Bush, MS
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Duke University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of this project is to investigate the effects of 12 weeks of high-intensity interval training (HIIT) and resistance training on several domains of health including physical function, cognitive function, mental health, and quality of life in patients who have undergone hematopoietic stem cell transplant (HCT). In addition, the project will determine the effects of 12 weeks of HIIT and resistance training on physical function, caregiver strain, mental health, and caregiver confidence in individuals who are providing care for patients undergoing HCT.

Do I need to stop my current medications to join the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Exercise training for blood cancers survivorship?

Research shows that exercise therapy can help cancer patients by reducing side effects like fatigue and depression, and improving overall quality of life. Exercise is safe and beneficial for cancer patients, helping them cope with treatment and recover better.12345

Is exercise training safe for people with blood cancers?

Exercise is generally safe for people with cancer, including those with blood cancers, and can improve fitness and reduce negative effects of cancer treatments.678910

How does exercise training differ from other treatments for blood cancers?

Exercise training is unique because it focuses on improving physical and psychological well-being through physical activity, rather than using medication or surgery. It is generally safe and feasible, offering benefits like reduced fatigue and improved muscle function, but more research is needed to establish specific guidelines for its use in blood cancer patients.79101112

Research Team

CL

Chenyu Lin, MD

Principal Investigator

Duke University

Eligibility Criteria

This trial is for English-speaking adults over 18 who have had a hematopoietic stem cell transplant (HCT) within the last 60 to 120 days, as well as their caregivers. It's designed to help improve various aspects of health post-transplant.

Inclusion Criteria

I am taking care of someone who has had a stem cell transplant.
I had a bone marrow transplant from a donor within the last 60 to 120 days.
I'm sorry, it seems like you did not complete the criteria. Could you please provide me with more information?
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 12 weeks of high-intensity interval training (HIIT) and resistance training to improve physical and cognitive function, mental health, and quality of life

12 weeks
Regular visits for exercise sessions and assessments

Follow-up

Participants are monitored for changes in physical function, mental health, and quality of life post-intervention

1 year
Assessments at baseline, post-intervention, and 1 year

Treatment Details

Interventions

  • Exercise training
Trial OverviewThe study is testing a program that includes high-intensity interval training (HIIT) and resistance exercises over a period of 12 weeks. The goal is to see how this exercise regimen affects physical function, cognitive abilities, mental health, and overall quality of life after HCT.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: PatientExperimental Treatment1 Intervention
These are patients who are 90 (±30) days post-allogeneic hematopoietic stem cell transplant. Patients will complete 12 weeks of exercise training. Patients will also complete assessments to evaluate physical function, cognitive function, mental health, social support, nutrition and diet, symptoms, quality of life, and financial status. They will use devices to capture activity data and vital signs. They will collect bio-specimens to assess microbiota and biomarkers.
Group II: CaregiverExperimental Treatment1 Intervention
These are the assigned caregivers for the transplant patients. Caregivers will complete 12 weeks of exercise training. Caregivers will also complete assessments to evaluate physical function, caregiver support, and physical activity and exercise. They will collect bio-specimens to assess microbiota.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Duke University

Lead Sponsor

Trials
2,495
Recruited
5,912,000+

Findings from Research

Exercise is an effective therapeutic intervention for cancer patients, helping to reduce side effects from treatments and significantly improving their quality of life during and after treatment.
Engaging in exercise before, during, and after cancer treatments leads to numerous beneficial outcomes, making it a crucial part of care for both patients undergoing treatment and survivors.
Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review.Mustian, KM., Sprod, LK., Janelsins, M., et al.[2021]
Exercise training is a safe and well-tolerated adjunct therapy for cancer patients, showing potential to reduce treatment-related side effects during and after adjuvant therapy.
Current evidence suggests that incorporating exercise into the care plan for cancer survivors may enhance their overall management, although further research is needed to fully understand its benefits across different stages of cancer survivorship.
Exercise therapy in the management of solid tumors.Jones, LW., Peppercom, J., Scott, JM., et al.[2021]
Regular physical exercise is associated with a reduced risk of developing colorectal and breast cancer, and may also lower the risk for prostate, endometrial, and lung cancers, based on a review of recent literature.
Exercise is beneficial for cancer survivors, aiding in recovery from treatment and potentially extending survival, although specific guidelines on the optimal amount, type, and intensity of exercise are still being developed.
Exercise in cancer.Rajarajeswaran, P., Vishnupriya, R.[2021]

References

Exercise Recommendations for Cancer-Related Fatigue, Cognitive Impairment, Sleep problems, Depression, Pain, Anxiety, and Physical Dysfunction: A Review. [2021]
Exercise therapy in the management of solid tumors. [2021]
Exercise in cancer. [2021]
The impact of supervised exercise intervention on short-term postprogram leisure time physical activity level in cancer patients undergoing chemotherapy: 1- and 3-month follow-up on the body & cancer project. [2019]
[Physical activity and exercise therapy in oncology]. [2023]
Exercise Training for Cancer Survivors. [2021]
Safety and feasibility of exercise interventions in patients with hematological cancer undergoing chemotherapy: a systematic review. [2023]
Efficacy of exercise training for improving vascular dysfunction in people with cancer: a systematic review with meta-analyses. [2023]
Exercise in adult and pediatric hematological cancer survivors: an intervention review. [2013]
10.United Statespubmed.ncbi.nlm.nih.gov
Rehabilitation and exercise considerations in hematologic malignancies. [2016]
Effects of an exercise-based oncology rehabilitation program and age on strength and physical function in cancer survivors. [2021]
Physical activity and hematological cancer survivorship. [2015]