Lung Transplant Techniques for Lung Transplant
Trial Summary
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Off-pump lung transplantation and Venoarterial ECMO for lung transplant?
Research suggests that using venoarterial extracorporeal membrane oxygenation (VA ECMO) during lung transplants may be more effective than off-pump support for patients without severe lung blood pressure issues. VA ECMO is increasingly used and may offer better outcomes compared to traditional methods.12345
How does the treatment Off-pump lung transplantation with Venoarterial ECMO differ from other treatments for lung transplantation?
Off-pump lung transplantation with Venoarterial ECMO (VA ECMO) is unique because it avoids the use of cardiopulmonary bypass, which can reduce the risk of bleeding and primary graft dysfunction. This approach also allows for better chest wall function and less postoperative pain compared to traditional methods that use extracorporeal circulation.13467
What is the purpose of this trial?
The purpose of this research study is to compare the technique of performing bilateral lung transplantation off-pump vs venoarterial ECMO (VA ECMO). The goal of the trial is to determine which technique has lower rates of primary graft dysfunction.
Research Team
Mauricio Villavicencio, MD, MBA
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for people who need both lungs replaced and can have surgery with or without a heart-lung machine (ECMO), as decided by their surgeon. They must have a certain level of blood pressure in the lungs to qualify. It's not for those needing only one lung, multiple organs, re-transplants, or who had major lung surgeries before.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo bilateral lung transplantation using either off-pump or VA ECMO techniques
Follow-up
Participants are monitored for safety and effectiveness, including incidence of PGD, mortality, and other complications
Long-term follow-up
Participants are monitored for long-term outcomes such as transplant rejection and overall survival
Treatment Details
Interventions
- Off-pump lung transplantation
- Venoarterial ECMO lung transplantation
Off-pump lung transplantation is already approved in European Union, United States, Canada for the following indications:
- End-stage lung disease
- Cystic fibrosis
- Bronchiectasis
- Pulmonary hypertension
- Emphysema
- Pulmonary fibrosis
- End-stage lung disease
- Cystic fibrosis
- Bronchiectasis
- Pulmonary hypertension
- Emphysema
- Pulmonary fibrosis
- End-stage lung disease
- Cystic fibrosis
- Bronchiectasis
- Pulmonary hypertension
- Emphysema
- Pulmonary fibrosis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor