Low Dose CT Scan for Lung Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if lung cancer can be inherited by screening close family members of lung cancer patients. Researchers will use low-dose CT scans (a type of imaging test) to detect early signs of lung cancer in these family members. The trial seeks first-degree relatives (such as parents, siblings, or children) of lung cancer patients who are between 40 and 80 years old, have smoked fewer than 20 pack years, and have no history of lung cancer themselves. Participants must be able to undergo a chest CT scan and meet other health criteria. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could enhance early detection of lung cancer in families.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this low dose CT scan is safe for screening?
Studies have shown that low-dose CT (LDCT) scans are generally manageable for individuals undergoing lung cancer screening. Research from the National Lung Screening Trial found that among every 320 high-risk patients screened with LDCT over five years, one avoided dying from lung cancer. This finding suggests that LDCT can be a valuable tool for early cancer detection.
However, there is concern about radiation exposure during the scan. Although the radiation dose is lower than that of a regular CT scan, it remains present. It is important to weigh the benefits of early cancer detection against the risk of radiation exposure.
The U.S. Preventive Services Task Force recommends yearly LDCT screenings for certain high-risk adults, indicating confidence in its safety and effectiveness when used correctly. While some risk exists, the opportunity to detect lung cancer early is a significant benefit.12345Why are researchers excited about this trial?
Researchers are excited about using low dose CT scans for lung cancer screening because this method potentially offers earlier detection of lung abnormalities in high-risk individuals, specifically first-degree relatives of lung cancer patients. Unlike standard screening options like chest X-rays or traditional CT scans, low dose CT scans use significantly less radiation while still providing detailed images of the lungs. This makes it a safer option for repeated screenings, which is crucial for early detection and timely intervention in individuals with a genetic predisposition to lung cancer.
What evidence suggests that a low dose CT scan is effective for early detection of lung cancer?
Research has shown that low-dose CT scans can be very effective for lung cancer screening. Studies have found that early detection with these scans greatly improves survival chances. For instance, individuals diagnosed with stage 1A lung cancer have more than a 75% chance of living for five years, compared to less than a 5% chance when cancer is detected at a later stage. This trial will specifically use low-dose CT scans to screen first-degree relatives of lung cancer patients with a known driver mutation. Early findings suggest these scans can also detect lung cancer more frequently in people who have never smoked but have a family history of the disease.678910
Are You a Good Fit for This Trial?
This trial is for immediate family members, aged 40-80, of lung cancer patients with a genetic mutation. It aims to explore if lung cancer can be inherited and detected early.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Screening
Immediate family members of lung cancer patients are screened using a low dose CT scan
Follow-up
Participants are monitored for lung abnormalities and potential lung cancer development
What Are the Treatments Tested in This Trial?
Interventions
- Low Dose CT Scan
Trial Overview
The study involves screening participants using a low dose CT scan to identify any early signs of lung cancer potentially linked to inherited mutations.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
First degree relatives of patients with lung cancer with a known driver mutation will receive a low dose CT scan of the chest to screen for lung abnormality.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Irvine
Lead Sponsor
Citations
Low‐dose computed tomography lung cancer screening
Early lung cancer detection leads to better survival outcomes: patients diagnosed with stage 1A lung cancer have a >75% 5‐year survival rate, compared to <5% at ...
Low-Dose CT Screening for Lung Cancer: Evidence from 2 ...
A single-center trial estimated a 0.05% additional risk of cancer after 10 years of screening and associated follow-up imaging, and one ...
Reduced Lung-Cancer Mortality with Low-Dose Computed ...
A total of 96.4% of the positive screening results in the low-dose CT group and 94.5% in the radiography group were false positive results. The ...
Review Current evidence of low-dose CT screening benefit
Early results showed higher lung cancer detection rates in people who have never smoked with a family history of lung cancer (1.7 %) than in ...
Improve lung cancer outcomes with low-dose CT screening
“Fortunately, lung screening with low dose CT is highly effective in reducing the rate of lung cancer deaths and has been shown to be ...
Lung cancer screening with low dose CT and radiation ...
One general concern about lung cancer screening with LDCT is the potential harm associated with exposition to ionizing radiations employed in the LDCT screening ...
Lung Cancer Screening: Pros and Cons
The National Lung Screening Trial showed that one in 320 high-risk patients screened with low-dose CT over five years will avoid death from lung cancer.
Low-dose CT Scans and Lung Cancer Screening in ...
Lung cancer was confirmed in 3.6% of the positive screenings in the low-dose CT group and in 5.5% of the positive screenings in the X-ray group.
9.
cms.gov
cms.gov/medicare-coverage-database/details/nca-decision-memo.aspx?NCAId=274&bc=AAAAAAAAAgAAAAScreening for Lung Cancer with Low Dose Computed ...
Two randomized trials of screening with chest radiography or low-dose CT are currently under way and will better inform lung cancer screening decisions.”
10.
uspreventiveservicestaskforce.org
uspreventiveservicestaskforce.org/uspstf/recommendation/lung-cancer-screeningRecommendation: Lung Cancer: Screening
The USPSTF recommends annual screening for lung cancer with LDCT in adults aged 50 to 80 years who have at least a 20 pack-year smoking history.
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