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Imaging
MRI Scans for Chronic Lung Disease
N/A
Recruiting
Led By Grace E Parraga, PhD
Research Sponsored by Western University, Canada
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Subjects male and female aged 18-75 with diagnosed lung disease including but not limited to: asthma, emphysema, Chronic Obstructive Pulmonary Disease (COPD), bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, lymphangioleiomyomatosis (LAM) and Bronchiolitis obliterans organizing pneumonia (BOOP)
Subject must be able to perform a breathhold for 16s
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
Study Summary
This trial will scan men and women aged 18-85 who have lung disease using MRI, to measure their lung function.
Who is the study for?
This trial is for men and women aged 18-75 with various lung diseases who can hold their breath for 16 seconds, have an FEV1 >25% predicted, and a Forced Vital Capacity (FVC) >25% predicted. Participants must understand the study and consent to join. Exclusions include having metal implants or conditions that prevent MRI use like severe claustrophobia.Check my eligibility
What is being tested?
The study tests how well Magnetic Resonance Imaging (MRI) using hyperpolarized helium can show changes in lungs of chronic lung disease patients over time by measuring things like Apparent Diffusion Coefficient (ADC), ventilation defects, and percent ventilation.See study design
What are the potential side effects?
There are generally no side effects associated with undergoing an MRI scan itself; however, some individuals may experience discomfort from holding their breath or lying still during the procedure.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18-75 years old with a diagnosed lung condition.
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I can hold my breath for 16 seconds.
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I can perform lung function tests consistently.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Lung function as measured using inhaled gas MRI ventilation defect percent (VDP)
Secondary outcome measures
Lung microstructure as measured using inhaled gas MRI Apparent Diffusion Coefficients (ADC)
Trial Design
1Treatment groups
Experimental Treatment
Group I: MRI at baseline and over timeExperimental Treatment1 Intervention
Patients with chronic lung disease will undergo pulmonary function tests, hyperpolarized Helium and or Xenon MRI at each visit.
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Who is running the clinical trial?
Western University, CanadaLead Sponsor
239 Previous Clinical Trials
56,821 Total Patients Enrolled
Grace E Parraga, PhDPrincipal InvestigatorRobarts Research Institute, The University of Western Ontario
14 Previous Clinical Trials
1,264 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a device or metal in your body that cannot be taken out, like a pacemaker or surgical staples.I cannot have an MRI due to having metal implants or a pacemaker.Your FEV1 (a measure of lung function) is greater than 25% of what is expected for someone your age, height, and gender.Your lung function as measured by Forced Vital Capacity (FVC) should be greater than 25% of what is expected and above 0.5 liters.Your oxygen level is less than 90% when lying down during the day.You have been hurt by a metal object that was not taken out.I am between 18-75 years old with a diagnosed lung condition.I can hold my breath for 16 seconds.I am in stable health aside from my current condition.I can perform lung function tests consistently.
Research Study Groups:
This trial has the following groups:- Group 1: MRI at baseline and over time
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are individuals over 40 being accepted into the trial?
"The minimum entry age for this trial is 18 and the maximum limit of participation is 75 years old."
Answered by AI
What criteria must one meet to be considered a viable participant in this research endeavor?
"This medical trial is looking for 100 participants with a diagnosis of lung disease, and that are between 18 to 75 years old."
Answered by AI
What is the current enrollment limit for this investigation?
"Correct. According to clinicaltrials.gov, this medical study is actively seeking out volunteers; it was first listed on November 1st 2007 and has been recently updated on May 10th 2023. The trial requires 100 people to be recruited from 2 separate medical centres."
Answered by AI
Are participants still being taken for this research project?
"According to clinicaltrials.gov, this investigation is actively seeking participants; it was established on November 1st 2007 and the most recent update was May 10th 2023."
Answered by AI
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