Transcranial Magnetic Stimulation for Word-Finding Difficulty

(CSST Trial)

Overseen By Rutvik H Desai, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of South Carolina

Disqualifiers: Dementia, Alcohol abuse, Psychiatric, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

36 Participants Needed

Trial Summary

What is the purpose of this trial?

This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).

Eligibility Criteria

This trial is for native English speakers aged 18 to 40 who have difficulty finding words. It's not suitable for left-handed individuals, those with dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or severe vision/hearing issues that could affect task performance.

Inclusion Criteria

I am a native English speaker.

I am between 18 and 40 years old.

Exclusion Criteria

Contraindication to TMS as determined by a standard TMS screening form

Contraindication to MRI as determined by a standard MRI screening form

Left-handed participants

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants undergo a structural MRI scan for TMS target localization

1 week

1 visit (in-person)

TMS and Task Performance

Participants perform lexical, semantic, and number judgment tasks with TMS applied at different time points

30 minutes per session

Multiple sessions (in-person)

Follow-up

Participants are monitored for any delayed effects of TMS and data analysis is conducted

4 weeks

Treatment Details

Interventions

• Single-pulse TMS

Trial Overview The study is testing how a single pulse of Transcranial Magnetic Stimulation (TMS) affects the activation timing of the left anterior temporal lobe during word processing tasks.

Participant Groups

Group I: TMS Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

University of South Carolina

Lead Sponsor

Trials

233

Recruited

122,000+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials

377

Recruited

190,000+