Quick Renal MRI for Pediatric Kidney Disease

Overseen By Shannon Cannon, MD

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Wisconsin, Madison

Disqualifiers: No pyuria, Negative urine culture, MRI contraindications, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI. This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. If the quick renal MRI is accurate, it could potentially replace the DMSA scan for those specific questions and ease the burden of testing for children with chronic renal disease. Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology. Participants will be 0-21 years of age and can expect to be on study for from 1 week (if enrolled in Aim 1) to 6 months (if enrolled in Aim 2).

Who Is on the Research Team?

Shannon Cannon, MD

Principal Investigator

University of Wisconsin, Madison

Are You a Good Fit for This Trial?

This trial is for children and young adults (0-21 years) with kidney conditions like infections or scarring, who are already getting DMSA scans as part of their care. It's not for those uncomfortable with MRI, without signs of infection in urine tests, negative urine cultures, or who can't have an MRI due to other medical reasons.

Inclusion Criteria

I am in the hospital for a fever and kidney infection, getting a special kidney scan.

I have had more than one urinary tract infection in the last year.

You are currently having DMSA scans as part of your regular medical care.

Exclusion Criteria

Your urine test does not show any signs of infection.

I am not comfortable with undergoing a Quick MRI.

You cannot have an MRI for medical reasons.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Aim 1: Acute Pyelonephritis Evaluation

Inpatients with acute pyelonephritis undergo a clinical DMSA scan and quick MRI within one week of each other.

1 week

2 visits (inpatient)

Aim 2: Renal Scarring Evaluation

Patients with renal scarring undergo a clinical DMSA scan and quick MRI within 6 months of each other.

6 months

2 visits (outpatient)

Follow-up

Participants are monitored for safety and effectiveness after imaging procedures.

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Quick MRI

Trial Overview The study is testing a new 'quick renal MRI' method against the standard DMSA scan used to detect kidney infections and scarring. The goal is to see if this quick MRI can be a faster, safer option that doesn't need injections, sedation, or radiation.

How Is the Trial Designed?

Group I: DMSA/Quick MRI Experimental Treatment 1 Intervention

All participants will go through DMSA and Quick MRI scan to help determine the validity of the Quick Renal MRI in pediatric kidney disease.

Who Is Running the Clinical Trial?

University of Wisconsin, Madison

Lead Sponsor

Trials

1,249

Recruited

3,255,000+