IDRX-42 for GIST
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests IDRX-42, an oral drug designed to block proteins that help cancer grow, in adults with advanced GIST who haven't responded to other treatments. The goal is to see if the drug is safe and effective.
Do I have to stop taking my current medications for the IDRX-42 trial?
The trial does not specify if you need to stop taking your current medications, but it does require that any side effects from previous treatments are resolved to a mild level or baseline before starting the study drug.
What data supports the effectiveness of the drug IDRX-42 for treating GIST?
Are You a Good Fit for This Trial?
Adults with advanced GIST that can't be surgically removed or has spread, who have tried other treatments like imatinib and possibly others without success. They should be in good physical condition (ECOG 0-1) and have recovered from previous treatment side effects.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dose Escalation (Phase 1)
Participants receive escalating doses of IDRX-42 to assess safety, tolerability, and pharmacologic profile
Phase 1b Expansion
Participants are enrolled in cohorts based on prior lines of therapy to assess preliminary antitumor effect and further characterize safety
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- IDRX-42
Find a Clinic Near You
Who Is Running the Clinical Trial?
IDRx, Inc.
Lead Sponsor