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Behavioural Intervention

High-Intensity Interval Exercise for Insulin Sensitivity

N/A

Recruiting

Research Sponsored by University of Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Eumenorrheic (female only), defined as menstrual cycle lengths ≥ 21 days and ≤ 35 days resulting in 9 or more consecutive periods per year

Age between 18-35 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 hours

Awards & highlights

Study Summary

This trial is exploring if a type of exercise called HIIE can help improve blood sugar control & reduce the risk of diabetes, esp. in females. It'll also look if changes to muscle explain how HIIE helps blood sugar.

Who is the study for?

This trial is for healthy, non-smoking men and women aged 18-35 with a BMI of 18-27 who are moderately active but not training for sports. Women must have regular menstrual cycles and can't be using oral contraceptives or be pregnant. Participants should not have metabolic diseases, be on blood glucose medications, or follow low-carb diets.Check my eligibility

What is being tested?

The study aims to see if one session of high-intensity interval exercise (HIIE) improves blood sugar control in both males and females compared to just resting. It also investigates how HIIE affects muscle metabolism related to blood sugar improvements.See study design

What are the potential side effects?

Since the intervention involves high-intensity exercise, potential side effects may include temporary muscle soreness, fatigue, shortness of breath during activity, and an increased risk of injury if exercises are performed incorrectly.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My menstrual cycles are regular, lasting 21 to 35 days.

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I am between 18 and 35 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Insulin area under the curve

Secondary outcome measures

Glucose area under the curve

Insulin:glucose ratio

Local muscle oxygenation

+10 more

Trial Design

2Treatment groups

Experimental Treatment

Group I: MalesExperimental Treatment2 Interventions

Male participant group

Group II: FemalesExperimental Treatment2 Interventions

Female participant group

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor

690 Previous Clinical Trials

1,019,619 Total Patients Enrolled

3 Trials studying Exercise

84 Patients Enrolled for Exercise

Stephanie Esfafanos, MScStudy DirectorUniversity of Toronto

Stephanie Estafanos, MScStudy DirectorUniversity of Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the cut-off age for participants in this experiment over 30 years old?

"To be eligible for the trial, participants must fall within a narrow age bracket of 18 to 35 years old. For those under 18 or over 65, 39 and 160 trials respectively are available."

Answered by AI

What criteria must a person meet to become an eligible participant in this trial?

"This trial seeks 24 volunteers aged 18 to 35 who are accustomed to physical activity, with a BMI in the range of 18-27 kg/m2 and have engaged in 1-3 structured exercise sessions weekly for at least six months. In addition, they must be non-smokers, not training for any particular sport and females should display eumenorrheic behaviour (menstrual cycle lengths between 21–35 days). Lastly, their VO2peak rating ought to match CSEP's 'fair' or 'good' normative fitness values according to gender."

Answered by AI

How many participants are sought for this medical experiment?

"Affirmative. Clinicaltrials.gov states that the recruitment for this clinical trial is ongoing, having been first posted on October 15th 2023 and updated as recently as November 2nd. The study requires 24 participants which will all be recruited from a single site."

Answered by AI

Are there still openings for volunteers in this research endeavor?

"Yes, the information on clinicialtrials.gov confirms that this investigation is actively looking for participants. It was originally posted on October 15th 2023 and had its last update on November 2nd of same year. This study requires 24 people at one medical centre to be recruited."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Does Biological Sex Influence Insulin Sensitivity and Muscle Metabolism Following High-intensity Interval Exercise?

Jenna Gillen 2023. "Does Biological Sex Influence Insulin Sensitivity and Muscle Metabolism Following High-intensity Interval Exercise?". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06074003.