Serotonin Signalling for Inflammatory Bowel Disease
(IBD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to explore how serotonin, a chemical important for gut function, behaves differently in people with inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Researchers seek to understand changes in serotonin signaling, as this might explain symptoms that persist even when the disease appears controlled. The trial seeks participants diagnosed with either Crohn's disease or ulcerative colitis, as well as healthy individuals to serve as controls. As an unphased trial, this study offers participants the chance to contribute to groundbreaking research that could enhance understanding and management of these conditions.
Do I need to stop my current medications to join the trial?
If your current medications directly affect serotonin signaling, you may need to stop them to join the trial. The study excludes participants taking such medications.
Is there any evidence suggesting that this treatment is likely to be safe for humans?
Research has shown that serotonin is a complex chemical in the body, crucial for communication in the gut. Studies have found links between changes in serotonin levels and gut issues like ulcerative colitis and Crohn's disease.
While specific safety information on altering serotonin levels for these conditions is limited, serotonin itself is well-researched. It plays many roles in the body, and its effects can vary based on different factors. Treatments affecting serotonin have generally been used safely for other conditions, but they require careful management to avoid issues like serotonin syndrome, which can cause confusion, fever, and muscle twitching.
In summary, although detailed safety data for this treatment in inflammatory bowel disease (IBD) is limited, serotonin's role in the body is well understood. This suggests that, with proper medical guidance, treatments targeting serotonin can be safe. However, participants should always discuss potential risks with their healthcare provider.12345Why are researchers excited about this trial?
Researchers are excited about investigating serotonin signaling in IBD (Inflammatory Bowel Disease) patients because it offers a new approach to managing the condition. Most current treatments for IBD, like biologics and corticosteroids, aim to reduce inflammation by targeting the immune system. However, this new treatment focuses on serotonin, a neurotransmitter more commonly associated with mood, but which also plays a role in gut function. By targeting serotonin pathways, researchers hope to address the underlying mechanisms of IBD in a novel way, potentially leading to more effective and targeted therapies. This could mean fewer side effects and a better quality of life for patients.
What evidence suggests that investigating serotonin signalling could be effective for inflammatory bowel disease?
This trial will investigate serotonin signaling for inflammatory bowel disease. Studies have shown that serotonin, a chemical that aids mood and digestion, might play a role in inflammatory bowel diseases like Crohn's disease and ulcerative colitis. Research indicates that individuals with these conditions often have an increased number of serotonin-producing cells in the gut. This increase might alter serotonin function, affecting the gut's normal operations. In some cases, these changes appeared even when patients were in remission but still experienced symptoms similar to irritable bowel syndrome. Animal studies also support the link between serotonin and gut inflammation. While more research is needed, these findings suggest that targeting serotonin might help treat these conditions.678910
Who Is on the Research Team?
Waliul I Khan, MBBS, PhD.
Principal Investigator
Dept. of Pathology & Molecular Medicine, McMaster University, Hamilton, Canada.
John Marshall, MD, MSc, FRCPC, AGAF.
Principal Investigator
Department of Medicine, McMaster University, Hamilton, Canada.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
Samples are collected to measure TPH1 gene expression and serotonin receptor levels
Follow-up
Participants are monitored for safety and effectiveness after sample collection
What Are the Treatments Tested in This Trial?
Interventions
- Investigating Serotonin Signalling
Find a Clinic Near You
Who Is Running the Clinical Trial?
McMaster University
Lead Sponsor
Citations
Characterization of Serotonin Signaling Components in ...
These findings revealed important information on various components of 5-HT signaling in intestinal inflammation which may ultimately lead to effective ...
Investigating Serotonin Signalling in IBD Patients
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD).
Clinical outcomes associated with antidepressant use in ...
Many AMs enhance serotonin (5-HT) availability, but this phenomenon may actually worsen IBD. We hypothesized that use of 5-HT-enhancing AMs ...
Selective serotonin reuptake inhibitors and inflammatory ...
In a qualitative questionnaire-based online survey by Mikocka-Walus et al., most IBD patients observed no difference with taking the SSRIs, and only 25% ...
Interplay between Serotonin, Immune Response, and ...
The aim of this study is to integrate scientific data linking the intestinal microbiota as a regulator of gut serotonin signaling and re-uptake.
Serotonin Syndrome: Pathophysiology, Clinical Features ...
Serotonergic signalling is a tightly regulated process characterised by a combination of feedback loops, multiple reuptake mechanisms, and ...
Perinatal serotonin signalling dynamically influences the ...
We use a longitudinal imaging approach to investigate how genetics, pharmacology, and aversive experience disrupt state-dependent serotonin signalling.
Serotonin
Safety data sheet (SDS), External MSDS. Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). check ...
The Serotonin Signaling System: From Basic ...
Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger utilized by enterochromaffin (EC) cells, which function as sensory ...
Serotonin signalling in cancer: Emerging mechanisms and ...
Serotonin has been demonstrated to enhance mitogen-stimulated B-cell proliferation via 5-HTR1A and 5-HTR3A, but it induced apoptosis through ...
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