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Vitamin Supplement
Acetaminophen and Vitamin C with Naproxen rescue for Acute Pain (Vicamed Trial)
N/A
Waitlist Available
Led By Raoul Daoust, MD MSc
Research Sponsored by Hopital du Sacre-Coeur de Montreal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 days
Awards & highlights
Vicamed Trial Summary
"This trial aims to determine if vitamin C can reduce pain intensity in patients with acute musculoskeletal pain over a seven-day period following an emergency department visit. Participants will either receive vitamin C or a placebo
Who is the study for?
This trial is for adults over 18 who visited the emergency department with acute musculoskeletal pain, like a fracture or sprain, that's lasted less than 48 hours. They should have a pain level of at least 4 out of 10 and be prescribed NSAIDs without opioids. It's not suitable for those who can't safely take vitamin C or acetaminophen.Check my eligibility
What is being tested?
The study tests if vitamin C can help reduce pain after an ED visit for acute musculoskeletal issues. Participants will either get vitamin C or a placebo twice daily for seven days, along with regular doses of acetaminophen. Naproxen is provided as backup if needed.See study design
What are the potential side effects?
Vitamin C is generally safe but may cause minor side effects like stomach upset in some people. Acetaminophen could lead to liver damage when used in large amounts or long-term, and naproxen may cause gastrointestinal issues.
Vicamed Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ seven days
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~seven days
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Daily pain intensity
Secondary outcome measures
Adverse events
NSAIDs consumption
New analgesic prescriptions
+6 moreVicamed Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Acetaminophen and Vitamin C with Naproxen rescueExperimental Treatment1 Intervention
900 mg vitamin C taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly
Naproxen 500 mg as a rescue medication
Group II: Acetaminophen and Placebo with Naproxen rescuePlacebo Group1 Intervention
Placebo taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly
Naproxen 500 mg as a rescue medication
Find a Location
Who is running the clinical trial?
Hopital de l'Enfant-JesusOTHER
16 Previous Clinical Trials
5,276 Total Patients Enrolled
2 Trials studying Acute Pain
2,704 Patients Enrolled for Acute Pain
The Ottawa HospitalOTHER
93 Previous Clinical Trials
62,372 Total Patients Enrolled
Hopital du Sacre-Coeur de MontrealLead Sponsor
51 Previous Clinical Trials
11,723 Total Patients Enrolled
3 Trials studying Acute Pain
3,465 Patients Enrolled for Acute Pain
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any available positions for patients to participate in this clinical trial?
"According to clinicaltrials.gov, this specific research investigation is not actively seeking participants. It was first listed on November 1st, 2024 and underwent its last update on March 5th, 2024. Despite the closure of recruitment for this particular study, there are currently 341 other trials welcoming eligible individuals at this time."
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