Probiotics for Chronic Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether the probiotic Lactobacillus Plantarum can help teens with chronic pain who have a higher body weight. The goal is to determine if this supplement provides relief from ongoing pain. Participants will take probiotic capsules for 7 to 11 weeks, with blood samples collected before and after the trial. Teens aged 13-17 with a body weight in the top 15% for their age may qualify to join. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new pain relief options for teens.
Do I need to stop my current medications to join the trial?
The trial requires that you do not use probiotics, prebiotics, antibiotics, or certain medications that affect gut function or inflammation, like metformin or non-steroidal anti-inflammatory drugs, for at least a month before joining. If you're on these, you may need to stop them to participate.
Is there any evidence suggesting that Lactobacillus Plantarum is likely to be safe for humans?
A previous study found Lactobacillus plantarum 299v safe for oral use, even over extended periods. Research shows that people have safely used it with other probiotics for up to nine months. Some individuals might experience minor side effects like gas, but serious issues are rare. This probiotic has also been safely added to foods, indicating it is generally well-tolerated. However, it may not be suitable for individuals with weakened immune systems or certain health conditions.12345
Why are researchers excited about this trial?
Unlike the standard treatments for chronic pain, which often involve medications like opioids or NSAIDs that can have significant side effects, the probiotic Lactobacillus Plantarum (specifically the strain Lp299v) offers a natural alternative. Researchers are excited about this treatment because it harnesses beneficial bacteria to potentially reduce pain by improving gut health and reducing inflammation. This approach not only targets pain differently but also minimizes the risk of side effects associated with long-term use of traditional pain medications.
What evidence suggests that Lactobacillus Plantarum might be an effective treatment for chronic pain?
Research has shown that Lactobacillus plantarum, a type of helpful bacteria, can reduce pain. Studies have found it eases stomach pain and bloating. Evidence also indicates it can lessen nerve pain, which arises from damaged nerves. This probiotic appears to work by balancing gut bacteria, linked to pain relief. In this trial, participants will receive Lactobacillus plantarum as the probiotic supplement Lp299v. These findings suggest Lactobacillus plantarum may be a promising option for managing long-term pain.36789
Are You a Good Fit for This Trial?
This trial is for young people aged 13-17 who are experiencing chronic pain, have a BMI in the 85th percentile or higher, and do not use drugs that affect gut function or inflammation. It's not for those on recent antibiotics/probiotics, with severe inflammatory diseases (except certain thyroid/asthma conditions), poor reactions to needles, pregnant/lactating females, or any condition that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single-strain probiotic (Lactobascillus Plantarum, Lp299v) for 7-11 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Lactobacillus Plantarum
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor