210 Participants Needed

Point of Care Testing for Toxoplasmosis

YZ
RM
MC
Overseen ByMarcela Cid
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new, quick method for detecting toxoplasmosis, an infection particularly risky for pregnant women. Researchers aim to determine if this new test, called toxoplasma ICT IgG-IgM BK, matches the accuracy of the current FDA-approved standard test. The trial invites adults who are not between 17-27 weeks pregnant and are willing to participate. By comparing results from the new and standard tests, the study seeks to evaluate the new test's effectiveness in real-world settings. As an unphased trial, it offers participants the opportunity to contribute to important research that could enhance toxoplasmosis testing.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications, so it's unclear. It's best to ask the trial organizers for more details.

What prior data suggests that this point of care testing device is safe for use?

Research shows that the Toxoplasma ICT IgG-IgM BK test is generally safe. Studies have found that this test accurately detects Toxoplasma antibodies. It employs immune chromatography, a method common in other medical tests and typically well-tolerated.

Since the test doesn't involve medications or treatments, side effects are unlikely. No reports have linked negative effects directly to this test. While comparisons with other standard tests continue, it appears to be a safe option for detecting Toxoplasmosis antibodies.12345

Why are researchers excited about this trial?

Unlike traditional methods for diagnosing toxoplasmosis, which often require lab-based tests that can be time-consuming and resource-intensive, the Point of Care Testing for Toxoplasmosis is unique because it uses the toxoplasma ICT IgG-IgM BK test. This test offers a quick and convenient way to determine if someone is positive or negative for toxoplasmosis directly at the point of care, without needing specialized laboratory equipment. Researchers are excited about this approach because it has the potential to significantly speed up the diagnostic process, making it easier to manage and treat the condition promptly.

What evidence suggests that this point of care testing device is effective for detecting toxoplasmosis?

Research has shown that the Toxoplasma ICT IgG-IgM BK test, used by participants in this trial, effectively detects Toxoplasma infections. Studies indicate it has 100% sensitivity, correctly identifying everyone with the infection. The test detects both new and long-term infections and provides results in about 30 minutes from a simple finger-prick. This test is reliable and effective for diagnosing toxoplasmosis, a condition caused by the Toxoplasma parasite.35678

Who Is on the Research Team?

RM

Rima McLeod, M.D.

Principal Investigator

University of Chicago

Are You a Good Fit for This Trial?

This trial is open to any adult willing to participate. It's designed for those who may have been exposed to Toxoplasmosis, a common infection usually caught from cats or contaminated food.

Inclusion Criteria

I am an adult willing to participate in the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Testing

Participants undergo testing using the Toxoplasma ICT IgG-IgM BK test and the standard predicate test

2 weeks
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after testing

1 year

What Are the Treatments Tested in This Trial?

Interventions

  • toxoplasma ICT IgG-IgM BK
Trial Overview The study is testing the Toxoplasma ICT IgG-IgM BK, a new point of care test that checks for current or past T. Gondii infections against standard FDA cleared tests using blood samples from volunteers.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: single groupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Chicago

Lead Sponsor

Trials
1,086
Recruited
844,000+

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/30393749/
Evaluation of Three Point-of-Care Tests for Detection ...Conclusions: The 3 evaluated POC kits revealed optimal sensitivity for Toxoplasma-IgG antibodies. The LDBIO-POC test exhibited 100% sensitivity ...
New test rapidly diagnoses Toxoplasma infections and ...An inexpensive, accurate test that detects infections with the parasite Toxoplasma gondii can provide results within 30 minutes from a finger-prick in a doctor ...
Evaluation of Three Point-of-Care Tests for Detection of ...The LDBIO-POC test exhibited 100% sensitivity for the combined detection of IgG/IgM in acute and chronic Toxoplasma infection. Biopanda and ...
Point-of-care testing for Toxoplasma gondii IgG/IgM using ...Our work demonstrates that the Toxoplasma ICT IgG-IgM test can function reliably as a point-of-care test to diagnose Toxoplasma gondii infection in the US.
Point of Care Testing for Toxoplasmosis · Info for ParticipantsThe Toxoplasma ICT IgG-IgM test has shown high sensitivity and specificity in detecting Toxoplasma antibodies, making it effective for diagnosing toxoplasmosis.
IgM Antibody Detection as a Diagnostic Marker for Acute ...This review summarizes current IgM detection methods and explores advancements aimed at improving diagnostic accuracy with a focus on recombinant antigens.
TOXOPLASMA ICT IgG-IgMTOXOPLASMA ICT IgG-IgM is a unitary qualitative rapid test based on the immune chromatography technology (lateral flow), allowing the simultaneous detection ...
Infectious Substances – Toxoplasma gondiiThese Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working ...
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