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Radiation Therapy

Radiotherapy Techniques for Sinonasal Malignancy

Waitlist Available
Led By Annie W Chan, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with biopsy proven locally advanced sinus, nasal cavity, hard palate, soft palate, major or minor salivary gland tumors, or lacrimal apparatus, with nasal cavity, sinus, auditory canal, or skull base involvement are eligible.
Eastern cooperative oncology group (ECOG) performance status 0 - 1 or Karnofsky Performance Status ≥ 70. (Appendix B)
Must not have
Be younger than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up5 years
Awards & highlights
No Placebo-Only Group

Study Summary

This trial will test whether IMRT or proton radiation therapy improves local control rates and lowers toxicity compared to conventional radiation therapy in the treatment of locally advanced sinonasal malignancy.

Eligible Conditions
  • Adenoid Cystic Carcinoma
  • Squamous Cell Carcinoma
  • Sinonasal Cancer
  • Sinonasal Carcinoma
  • Mucoepidermoid Carcinoma
  • Schneiderian Carcinoma
  • Myoepithelial Carcinoma
  • Esthesioneuroblastoma
  • Melanoma

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have been diagnosed with specific types of tumors in certain areas of the head and neck.
You are able to perform daily activities without any major limitations or only have minor limitations due to your health condition.
Your organs and bone marrow are working normally.
You have been diagnosed with specific types of cancer in the nasal and sinus area, as well as certain types of advanced stage tumors. The diagnosis must be confirmed by your treating hospital.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Local Control Rates
Secondary outcome measures
Local control
Neurocognitive function
Patterns of Tumor Relapse
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Proton beam therapyActive Control1 Intervention
Subjects treated at Massachusetts General Hospital with proton beam therapy
Group II: IMRTActive Control1 Intervention
Intensity-modulated radiation therapy at institutions other than Massachusetts General Hospital

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,862 Previous Clinical Trials
13,149,019 Total Patients Enrolled
National Institutes of Health (NIH)NIH
2,636 Previous Clinical Trials
6,670,975 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,486 Previous Clinical Trials
41,265,892 Total Patients Enrolled

Media Library

Intensity-modulated radiotherapy (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT01586767 — N/A
Adenoid Cystic Carcinoma Research Study Groups: Proton beam therapy, IMRT
Adenoid Cystic Carcinoma Clinical Trial 2023: Intensity-modulated radiotherapy Highlights & Side Effects. Trial Name: NCT01586767 — N/A
Intensity-modulated radiotherapy (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01586767 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the size of the cohort involved in this research?

"Affirmative, the data hosted on clinicaltrials.gov documents that this medical trial is currently recruiting patients. Initially posted in July 2011 and most recently updated June 2021, the study requires 90 participants to be recruited between two sites."

Answered by AI

Is enrollment for this trial still available to interested participants?

"Per the clinicaltrials.gov website, this trial is actively looking for participants to enrol in it; having first been posted on July 1st 2011 and updated as recently as June 2nd 2021."

Answered by AI
~3 spots leftby Nov 2024