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Genetic Test

Genetic Test for Hypercholesterolemia(ACCURATE Trial)

Led By Liam Brunham, MD PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age <60 years
Admitted to an acute cardiac unit with either a ST elevation myocardial infarction (STEMI), or a non-ST elevation myocardial infarction (NSTEMI)
Must not have
Be younger than 18 years old
Be older than 65 years old
Screening 3 weeks
Treatment Varies
Follow Up1 year
Awards & highlights
No Placebo-Only Group

ACCURATE Trial Summary

This trial will test whether genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and improve patient care and outcomes.

Eligible Conditions
  • Familial Hypercholesterolemia
  • High Cholesterol
  • Hypercholesterolemia
  • Heart Attack
  • Acute Coronary Syndrome
  • Myocardial Infarction

ACCURATE Trial Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You are younger than 60 years old.
You have been hospitalized for a heart attack.
Your cholesterol levels are too high, even if you are taking medication for it.

ACCURATE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of patients with a new diagnosis of FH
Secondary outcome measures
Lowest LDL-cholesterol (LDL-C) level achieved in the first year after ACS
Proportion of patients in whom lipid-lowering medication intensified, as defined by an increase the dose of statin, or the addition of a non-statin lipid-lowering medication, in the first year after ACS
Proportion of patients who achieve guideline recommended lipid targets in the first year after ACS
Other outcome measures
Rate of recurrent cardiovascular event in the first year after ACS

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

ACCURATE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Active-testingExperimental Treatment1 Intervention
Those admitted between 6-18 months of the study meeting the inclusion criteria. Saliva samples will be collected for DNA testing.
Group II: ObservationActive Control1 Intervention
Those admitted in the first 6 months of the study that meet the inclusion criteria. Patients will be treated according to the normal standard of care for acute coronary syndrome.

Find a Location

Who is running the clinical trial?

Vancouver Coastal Health Research InstituteOTHER
26 Previous Clinical Trials
5,036 Total Patients Enrolled
Genome British ColumbiaIndustry Sponsor
12 Previous Clinical Trials
222,992 Total Patients Enrolled
University of British ColumbiaLead Sponsor
1,381 Previous Clinical Trials
1,951,025 Total Patients Enrolled
4 Trials studying Hypercholesterolemia
243 Patients Enrolled for Hypercholesterolemia

Media Library

Research-based genetic test for Familial Hypercholesterolemia (Genetic Test) Clinical Trial Eligibility Overview. Trial Name: NCT05218005 — N/A
Hypercholesterolemia Research Study Groups: Observation, Active-testing
Hypercholesterolemia Clinical Trial 2023: Research-based genetic test for Familial Hypercholesterolemia Highlights & Side Effects. Trial Name: NCT05218005 — N/A
Research-based genetic test for Familial Hypercholesterolemia (Genetic Test) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05218005 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the current research trial open to individuals aged 40 and over?

"To meet the requirements for this study, prospective patients must be 18 years or older and under 60."

Answered by AI

Is participation in the experiment open to me?

"This clinical trial is searching for 250 individuals between 18 and 60 years of age who have been diagnosed with acute coronary syndrome. Additionally, the participants must meet other conditions such as having a LDL level greater than 4 mmol/L (154 mg/dL) if not taking statins or 2.5 mmol/L (96 mg/dL) on a current statin regimen, in addition to Non-HDL-C ≥4.6 mmol/L (177 mg/dL)."

Answered by AI

How many participants are enrolled in the current clinical experiment?

"Affirmative, the records on clinicaltrials.gov prove that this investigation is still open to new participants. It was posted initially on January 1st 2022 and updated lastly at the end of January 2021. The research aims to recruit a total of 250 individuals from two distinct sites."

Answered by AI

Does this investigation have any open enrollment spots?

"Affirmative. According to clinicaltrials.gov, this medical trial is actively searching for participants and was first posted on January 1st 2022 with a subsequent edit made at the end of the month. From two different sites combined, 250 individuals must be enrolled in order to complete the study's objectives."

Answered by AI
~28 spots leftby Apr 2024