Research-based genetic test for Familial Hypercholesterolemia for Familial Hypercholesterolemia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Familial Hypercholesterolemia+7 MoreResearch-based genetic test for Familial Hypercholesterolemia - DiagnosticTest
Eligibility
18 - 60
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test whether genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and improve patient care and outcomes.

Eligible Conditions
  • Familial Hypercholesterolemia
  • Heart Attack
  • High Cholesterol
  • Acute Coronary Syndrome
  • Familial Hypercholesterolemia with Hyperlipidemia
  • NSTEMI (Non ST Segment Elevation Myocardial Infarction)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 1 year

1 year
Lowest LDL-cholesterol (LDL-C) level achieved in the first year after ACS
Number of patients with a new diagnosis of FH
Proportion of patients in whom lipid-lowering medication intensified, as defined by an increase the dose of statin, or the addition of a non-statin lipid-lowering medication, in the first year after ACS
Proportion of patients who achieve guideline recommended lipid targets in the first year after ACS
Rate of recurrent cardiovascular event in the first year after ACS

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Observation
1 of 2
Active-testing
1 of 2

Active Control

Experimental Treatment

250 Total Participants · 2 Treatment Groups

Primary Treatment: Research-based genetic test for Familial Hypercholesterolemia · No Placebo Group · N/A

Active-testing
DiagnosticTest
Experimental Group · 1 Intervention: Research-based genetic test for Familial Hypercholesterolemia · Intervention Types: DiagnosticTest
ObservationNoIntervention Group · 1 Intervention: Observation · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

Genome British ColumbiaIndustry Sponsor
12 Previous Clinical Trials
222,697 Total Patients Enrolled
Vancouver Coastal Health Research InstituteOTHER
25 Previous Clinical Trials
5,004 Total Patients Enrolled
University of British ColumbiaLead Sponsor
1,325 Previous Clinical Trials
1,533,843 Total Patients Enrolled
Liam Brunham, MD PhDPrincipal InvestigatorUniversity of British Columbia

Eligibility Criteria

Age 18 - 60 · All Participants · 5 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a maximum lipid level of at least 5.0 mmol/L.
You have a LDL level ≥4 mmol/L (154 mg/dL) if not on a statin, or LDL-C level ≥2.