STOP-HPV Strategies for Human Papillomavirus Vaccines
What You Need to Know Before You Apply
What is the purpose of this trial?
Human papillomavirus (HPV) causes 35,900 US cancer cases per year, 4,000 deaths, and $4 billion in can In this study, the investigators will conduct a 3-arm clustered randomized controlled trial (RCT) in an estimated 72 practices from up to 8 health systems to evaluate the effectiveness and cost effectiveness of two potentially scalable implementation strategies (based on prior work) to increase the initiation of HPV vaccine against a usual care (control) arm. The intervention arms are 1) online provider communication training only ("STOP-HPV-Online" and 2) online provider communication training plus a Learning Collaborative, with performance feedback, attended by practice leads ("STOP-HPV-LC).
cer-related costs. It is recommended at ages 11-12 years routinely but can be given starting at ages 9-10 years. Despite having an effective vaccine, HPV vaccine initiation/completion rates in the U.S. were only at 76.8%/61.4% respectively in 2023 among 13-17 year olds; these rates are lower than the other recommended adolescent vaccines. Two key barriers are 1) suboptimal clinician communication to address parental concerns and 2) ineffective office systems causing missed vaccine opportunities.
Who Is on the Research Team?
Peter Szilagyi, MD, MPH
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
What Are the Treatments Tested in This Trial?
Interventions
- STOP-HPV-LC
- STOP-HPV-Online
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
Provider communication training
Provider communication training plus Learning Collaborative sessions attended by practice leads and quarterly performance feedback to the practice.
Standard of care control
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
American Medical Group Association
Collaborator
National Cancer Institute (NCI)
Collaborator
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