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Local Anesthetic

Low vs High Concentration Local Anesthesia for Hip Replacement (HALF Trial)

N/A

Recruiting

Led By Hermann dos Santos Fernandes, MD, PhD

Research Sponsored by University of Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients undergoing primary THA in the inpatient setting

Non-pregnant patients older than 21 years of age, with American Society of Anesthesiologists (ASA) physical status I-IV

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 hours after spinal anesthesia

Awards & highlights

HALF Trial Summary

This trial tests if using low-concentration local anesthetics for hip replacement surgery reduces pain while preserving muscle strength.

Who is the study for?

This trial is for adults over 21 years old who are having a primary total hip arthroplasty (hip replacement) in an inpatient setting. They should not be pregnant, have no severe anatomical issues, infections, or allergies to the study's medications, and must not be dependent on alcohol or drugs.Check my eligibility

What is being tested?

The study tests if low concentration local anesthetic (LCLA) used in fascia iliaca compartment block provides good pain control without causing muscle weakness after hip surgery compared to high concentration local anesthetic (HCLA).See study design

What are the potential side effects?

Possible side effects include temporary numbness or weakness in the leg due to nerve blockage. There may also be typical risks associated with anesthesia such as nausea or dizziness.

HALF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am having a total hip replacement surgery as an inpatient.

Select...

I am over 21, not pregnant, and fit for surgery according to ASA standards.

HALF Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 hours after spinal anesthesia

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 hours after spinal anesthesia

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 hours after spinal anesthesia for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Quadriceps muscle strenght

Secondary outcome measures

Opioid consumption

Pain scores

HALF Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Low Concentration Local Anesthetic Fascia Iliaca Compartment BlockExperimental Treatment1 Intervention

Patients will be submitted to a Suprainguinal Fascia Iliaca Block with low concentration local anesthetic (Ropivacaine 0.075%)

Group II: High Concentration Local Anesthetic Fascia Iliaca Compartment BlockActive Control1 Intervention

Patients will be submitted to a Suprainguinal Fascia Iliaca Block with high concentration local anesthetic (Ropivacaine 0.25%)

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor

690 Previous Clinical Trials

1,019,583 Total Patients Enrolled

Hermann dos Santos Fernandes, MD, PhDPrincipal InvestigatorUniversity of Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still space available to join this medical experiment?

"Affirmative. According to clinicaltrials.gov, this medical research has been open for participant recruitment since October 23rd 2023 and was last updated on 10/22/2023. Sixty participants are being sought from one study location."

Answered by AI

How many individuals have enrolled in this research project?

"Affirmative. Information available from clinicaltrials.gov suggests that this trial, first published on October 23rd 2023, is actively looking for volunteers to enroll. There are 60 positions open across 1 medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Low Concentration Local Anesthesia Fascia Iliaca Block for Total Hip Arthroplasty

Hermann dos Santos Fernandes 2023. "Low Concentration Local Anesthesia Fascia Iliaca Block for Total Hip Arthroplasty". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06102811.