Multi-Periscopic Prism (MPP) glasses for Hemianopsia

Phase-Based Estimates
Schepens Eye Research Institute, Boston, MA
Hemianopsia+1 More
Multi-Periscopic Prism (MPP) glasses - Device
Any Age
All Sexes
Eligible conditions

Study Summary

This study is evaluating whether a pair of glasses may help individuals with a specific type of vision loss.

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Eligible Conditions

  • Hemianopsia
  • Homonymous Hemianopia

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Multi-Periscopic Prism (MPP) glasses will improve 1 primary outcome and 4 secondary outcomes in patients with Hemianopsia. Measurement will happen over the course of After 4 weeks of wearing the second pair of prism glasses.

Week 4
Continuation rate (at end of crossover)
Device preference
At 6 months
Continuation rate (long term)
Week 4
Change in detection rate for hazards approaching from the blind side in the VR walking simulator test
Change in detection response time for hazards approaching from the blind side in the VR walking simulator test

Trial Safety

Trial Design

2 Treatment Groups

No Control Group
MPP first, FPP second

This trial requires 50 total participants across 2 different treatment groups

This trial involves 2 different treatments. Multi-Periscopic Prism (MPP) Glasses is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

MPP first, FPP secondParticipants in this arm will receive the MPP in the first period of the crossover and the FPP in the second period.
FPP first, MPP secondParticipants in this arm will receive the FPP in the first period of the crossover and the MPP in the second period.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: at 6 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly at 6 months for reporting.

Who is running the study

Principal Investigator
E. P.
Eli Peli, Senior Scientist
Massachusetts Eye and Ear Infirmary

Closest Location

Schepens Eye Research Institute - Boston, MA

Eligibility Criteria

This trial is for patients born any sex of any age. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The person has to be able to see from at least 20 feet away what someone with normal vision can see from 50 feet away. show original
The person has a visual impairment in one half of their field of vision that has lasted for at least six months show original
This person can walk without help and can use a cane or walker if needed. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has multi-periscopic prism (mpp) glasses proven to be more effective than a placebo?

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Multifocal periscopic Prisms are an effective treatment for binocular diplopia due to strabismus and amblyopia. Multi-periscopic prisms may become widely available within the next 4 years.

Unverified Answer

Can hemianopsia be cured?

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Despite the absence of any other symptom of hemianopsia in our case, we decided on treatment because the patient claimed that it had been a constant problem for a long time. We have only been successful in getting hemianopsia to disappear after the first surgery using subcarotidian approach. The clinical condition and symptoms of hemianopsia may be alleviated by the proper choice of the correct surgical approach.

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Does hemianopsia run in families?

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Because of the small population of our family with hemianopsia, we cannot conclude that the current findings support the existence of an HPAH1B1 gene. We found that only one of our four families showed any suggestive evidence of a polygenic basis in the inheritance of hemianopsia.

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What is hemianopsia?

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A hemianopsia may be caused by a variety of diseases. It may also be a symptom of certain kinds of visual disorders or a consequence of the aging process.\n\nHemianopsia in the context of a visual or peripheral field deficit is an infrequent symptom often associated with a number of diseases and disorders, most commonly, a posterior circulation anomaly.

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What are common treatments for hemianopsia?

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Hemianopsia often has an organic cause and requires specific treatment. There is no standard treatment as there is no treatment for the cause of the problem in most cases. An occlusal splint can be prescribed to help maintain occlusion and may be successful in some cases but further research is needed to determine the success rate. There is a lack of relevant research in this field. The authors conclude that there are no commonly accepted recommendations for patients with hemianopsia as a result of arterial occlusion as this is a rare condition in which little information is available.

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What are the signs of hemianopsia?

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Most patients with hemianopsia can recognize and name colors. Colors named often include black, yellow, orange, and red. However, there is a wide range of colors named by these patients, and they are not always easily recognized, especially white.

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How many people get hemianopsia a year in the United States?

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It is believed that about 0.1% of patients in general practice have the condition in at least 1 eye. Hemianipsia is much more common, at about 4%.

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What causes hemianopsia?

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A hemianopia is related to retinal abnormalities of the ONH and choroid of the left or right eye. Patients with an ONH hemianopia usually complain of a loss of contrast sensitivity on near vision in both eyes. This is the result of chorioretinal degeneration or optic neuropathy. Some patients have a gradual onset of bilateral hemianopsia. In these cases, a temporal hemianopsic defect may occur.

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Have there been any new discoveries for treating hemianopsia?

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There are still no effective ways to treat hemianopsia. At present, the most effective treatments are palliative measures that aim at reducing the discomfort and improving the quality of life of the patient. There are currently no specific therapies to treat hemianopsia currently available, but most new therapies are still in the early stages of research. To see a list of treatments for hemianopsia, visit Power(

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Have there been other clinical trials involving multi-periscopic prism (mpp) glasses?

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mpp glasses have resulted in an excellent reduction of amblyopia in children with ROP. However, the efficacy of Multiperiscopic Prims glasses can only be proven after randomized placebo-controlled clinical trials. We therefore advocate for the performance of a multi-centre trial in which the mpp glasses are tested on several different groups of children and compared to a control group treated with conventional eyeglasses. If favourable results are obtained, we recommend that all ROP patients receive Multiperiscopic Prims glasses in all cases.

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What is the latest research for hemianopsia?

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The only effective treatment for this form of visual deterioration is the combination of the retinal drug ranibizumab (Lucentis) and a complement inhibitor (inhibitor against the protein C system inhibitor). It should be used in conjunction with conventional treatment of other eye conditions. The only other treatment, if the hemianopsia does not respond to an initial course of ranibizumab, is the laser surgery.\n

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What is multi-periscopic prism (mpp) glasses?

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mpp prism glasses are safe and effective with a good visual acuity of 20/20 or better in a substantial number of patients with an acquired visual field defect. The most common side effects include increased glare and night blindness.

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