CLINICAL TRIAL

SQUID for Hematoma, Subdural, Chronic

Recruiting · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether a surgery which reduces bloodflow in a blood vessel in the brain may help treat chronic subdural hematoma.

See full description

About the trial for Hematoma, Subdural, Chronic

Eligible Conditions
Hematoma, Subdural · Hematoma · Hematoma, Subdural, Chronic

Treatment Groups

This trial involves 2 different treatments. SQUID is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
SQUID
DEVICE
Burr-hole
PROCEDURE
Medical Management
OTHER
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Burr-hole
PROCEDURE
Medical Management
OTHER

Eligibility

This trial is for patients born any sex aged 18 and older. There are 9 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
A person who is 30 years or older can give consent to sex. show original
Subject presents with one or more of the following neurological symptoms: headache; cognitive decline; speech difficulty or Aphasia; gait impairment or imbalance; focal neurological deficit (weakness, paresthesia or sensory deficit involving of one or more extremities or facial droop); and/or seizure
10. Subject is able and willing to return to the investigational site for all follow-up visits (e.g., 30-day, 90-day, 180-day and 1-year), as required per protocol
View All
Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
Similar Trials

Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: within 180-days of intervention
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: within 180-days of intervention.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether SQUID will improve 1 primary outcome in patients with Hematoma, Subdural, Chronic. Measurement will happen over the course of within 180-days of intervention.

Treatment failure
WITHIN 180-DAYS OF INTERVENTION
Residual or re-accumulation of the SDH (≥10 mm) or Re-operation (after index procedure) or surgical rescue or Any new, major disabling stroke after enrollment, myocardial infarction (MI) or death from any (neurological) cause

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get hematoma, subdural, chronic a year in the United States?

Most patients get a hematoma, subdural, or chronic a year in the United States, with about a third having an operation to control bleeding. Most hematomas (98%) and subdural bleeds, (83%) occur in men and women, respectively. Most bleeding (77%) and surgery (51%) occur between the ages of 20-49 years in men and 30-59 years in women. The study found that hematoma, subdural, and chronic were more common in the Northeast than in North or South. Because many of these bleeding events are preventable, some of the complications of hematoma, subdural, and chronic may be prevented.

Anonymous Patient Answer

What are the signs of hematoma, subdural, chronic?

The finding of an increased number of subdural hematomas on CT scan is a poor prognostic sign due to the high likelihood of further worsening in the intra-operative period.

Anonymous Patient Answer

What are common treatments for hematoma, subdural, chronic?

Many current therapies for hematomas, subdural, and chronic have been suggested by the WHO and EASL, but are still not widely used. There are, however, many studies reporting a decrease in complications and better function with the use of specific procedures.

Anonymous Patient Answer

What is hematoma, subdural, chronic?

  • Duration: 4 days or more\n- Symptoms: aseptic headache, vomiting, loss of consciousness, headache\n- Other signs or symptoms: cerebral cortical hemorrhage, increased intracranial pressure\n- Symptoms should be different but should not be improved by treatment: headache is not the only clinical presentation of hematoma, subdural, chronic.\n- The symptoms of hematoma, subdural, chronic must differ from the signs and symptoms of cerebrospinal fluid otorrhea or aseptic meningitis.
Anonymous Patient Answer

What causes hematoma, subdural, chronic?

There are many factors that lead to cerebral hemorrhage, such as low blood pressure, anticoagulation, cerebral atrophy, and trauma. However, in the case of ICH, it is important to know the mechanism of onset.

Anonymous Patient Answer

Can hematoma, subdural, chronic be cured?

Hematomas, subdural chronic are generally not manageable, and therefore it may be better to treat these as a sequel to a traumatic injury, or as a consequence of an iatrogenic injury.

Anonymous Patient Answer

What are the common side effects of squid?

Although our survey included only the subjects in Taipei, Taiwan, squid is exported from Taiwan and consumed in Taiwan. Therefore, our survey is valid to analyze our local squid consumption habits. The common side effects and the most common dosage of squid consumption reported by those participating in our survey are shown below.

Anonymous Patient Answer

What is the average age someone gets hematoma, subdural, chronic?

Patients with hematoma, subdural, chronic may be about 42 years of age on average. A subgroup of patients have a recent penetrating injury history from a bullet or blade. Patients with a subdural hematoma, subdural, or chronic are usually more sick and have not had a lot of time to fully recover after a trauma. It is important that the clinician be aware of the unique needs of these patients at admission until they are able to fully recover from their injury.

Anonymous Patient Answer

Have there been any new discoveries for treating hematoma, subdural, chronic?

Data from a recent study show that there appears to be no significant difference in efficacy of epidural steroid treatment for chronic subdural hematoma when compared with corticosteroids injected into a subcutaneous tissue. Data from a recent study does show a significant difference in effectiveness of epidural steroid injections into perivascular cuffs for patients who suffer a traumatic hematoma or subdural hematoma of chronic origin, when compared with corticosteroids injected into a subcutaneous area.

Anonymous Patient Answer

What are the latest developments in squid for therapeutic use?

Recent studies have discovered squid as a promising source of anti-inflammatory molecules. Given the anti-inflammatory and neuroprotective effects of squid, squid may offer a novel alternative to drugs currently used for treating neuroinflammation, such as anti-inflammatory agents and the proteasome inhibitor MG132, as it is a source with a wide spectrum of anti-inflammatory and neuroprotective molecules. squid, squid anti-inflammatory anti-mitochondrial autoantigen peptides, and squid anti-mitochondrial autoantigen may represent a promising therapeutic option for the future treatment of inflammatory disorders.

Anonymous Patient Answer

Have there been other clinical trials involving squid?

The study of the efficacy of squids as a treatment for patients with chronic traumatic subdural hematomas could provide further evidence concerning possible clinical applications of squids in the treatment of patients with brain injuries.

Anonymous Patient Answer

What is the primary cause of hematoma, subdural, chronic?

Primary subdural (or hematoma) after a traumatic event is associated with a large volume of hematoma at presentation or delayed clinical or radiological resolution, with chronic subdural (or hematoma) associated with smaller volumes of hematoma and more rapid clinical or radiological resolution. The incidence of [subdural, chronic, and epidural, chronic] after an initial traumatic event is high, and there is high heterogeneity in the cause-specific risk of developing these symptomatic (or hematoma) following a traumatic event.

Anonymous Patient Answer
See if you qualify for this trial
Get access to this novel treatment for Hematoma, Subdural, Chronic by sharing your contact details with the study coordinator.