60 Participants Needed

Blood Flow Restriction Training for Muscle Strength in Healthy Individuals

HP
Overseen ByHugo Pereira, PhD
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Oklahoma
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 2 JurisdictionsThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.

Do I need to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

How is blood flow restriction training different from other treatments for muscle strength?

Blood flow restriction training is unique because it uses low-load resistance exercises combined with restricted blood flow to the muscles, which can enhance muscle strength and growth without the need for heavy weights. This makes it a novel option compared to traditional high-load resistance training, especially for those who may not tolerate heavy lifting.12345

What data supports the effectiveness of the treatment Blood Flow Restriction Training for muscle strength in healthy individuals?

Research shows that Blood Flow Restriction Training (BFRT) can increase muscle mass and strength using low loads, making it an effective alternative to traditional high-intensity resistance training. It has been widely documented as beneficial in both athletic and clinical settings, with minimal serious side effects when applied correctly.24678

Who Is on the Research Team?

HP

Hugo Pereira, PhD

Principal Investigator

University of Oklahoma

Are You a Good Fit for This Trial?

This trial is for healthy individuals interested in participating in a study comparing different resistance training methods. Specific eligibility criteria are not provided, but typically participants must be generally healthy without major medical conditions.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo resistance training with or without blood flow restriction for 10 sessions

up to 6 weeks

Follow-up

Participants are monitored for changes in muscle activation, lean mass, and muscle size after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Blood flow restriction
  • Regular training type 1
  • Regular training type 2
Trial Overview The study is testing the effectiveness of resistance training with blood flow restriction against two types of regular resistance training. The goal is to see which method better increases muscle strength and size.
How Is the Trial Designed?
3Treatment groups
Experimental Treatment
Group I: Group 3Experimental Treatment1 Intervention
Conventional strength training using low loads
Group II: Group 2Experimental Treatment1 Intervention
Conventional strength training using high loads
Group III: Group 1Experimental Treatment1 Intervention
Strength training associated with blood flow restriction

Blood flow restriction is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Blood Flow Restriction Therapy for:
  • Achilles tendon rupture rehabilitation
  • Musculoskeletal injuries
  • Post-surgical rehabilitation
  • Arthritis
  • Tendinitis
  • ACL/meniscal tears
  • Non-union fractures
  • IT band issues
🇪🇺
Approved in European Union as Blood Flow Restriction Therapy for:
  • Achilles tendon rupture rehabilitation
  • Musculoskeletal injuries
  • Post-surgical rehabilitation
  • Arthritis
  • Tendinitis
  • ACL/meniscal tears
  • Non-union fractures
  • IT band issues

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Oklahoma

Lead Sponsor

Trials
484
Recruited
95,900+

Published Research Related to This Trial

Blood flow restriction training (BFRT) can be beneficial for rehabilitation but poses risks such as increased blood pressure and adverse cardiovascular responses, especially in individuals with pre-existing conditions like hypertension and diabetes.
To ensure safety, a risk stratification tool is recommended for clinicians to assess patients' medical histories and identify those who may be at higher risk for complications when undergoing BFRT.
A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation.Nascimento, DDC., Rolnick, N., Neto, IVS., et al.[2022]
High-load resistance exercise (HL) resulted in significantly greater quadriceps muscle activation compared to low-load blood flow restriction training (BFRT) using both regulated and standardized devices, indicating that traditional strength training may be more effective for muscle activation.
Participants reported higher pain and perceived exertion during the regulated BFRT sessions compared to the standardized BFRT and high-load resistance exercise, suggesting that while BFRT can be effective, it may also be associated with greater discomfort.
Comparison of blood flow restriction devices and their effect on quadriceps muscle activation.Bordessa, JM., Hearn, MC., Reinfeldt, AE., et al.[2021]
A study involving 136 Brazilian professionals in physical rehabilitation found that blood flow restriction (BFR) is primarily used with resistance exercise to promote muscle growth and rehabilitation, especially in young adults aged 20 to 29 years.
While 92% of professionals reported observing at least one side effect from BFR, most were mild, such as tingling and delayed muscle soreness, indicating that serious side effects are rare when BFR is applied correctly in clinical settings.
Application and side effects of blood flow restriction technique: A cross-sectional questionnaire survey of professionals.de Queiros, VS., Dantas, M., Neto, GR., et al.[2023]

Citations

Effects of exercise intensity and occlusion pressure after 12 weeks of resistance training with blood-flow restriction. [2022]
A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation. [2022]
Comparison of blood flow restriction devices and their effect on quadriceps muscle activation. [2021]
Application and side effects of blood flow restriction technique: A cross-sectional questionnaire survey of professionals. [2023]
Blood Flow Restriction Training in Clinical Rehabilitation: Occlusion Pressure Methods Relative to the Limb Occlusion Pressure. [2023]
Use of Blood Flow Restriction Training for Postoperative Rehabilitation. [2019]
Effects of Blood Flow Restriction Therapy for Muscular Strength, Hypertrophy, and Endurance in Healthy and Special Populations: A Systematic Review and Meta-Analysis. [2022]
Eight weeks of resistance training with blood flow restriction improve cardiac function and vascular endothelial function in healthy young Asian males. [2021]
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