Sweet Oranges for Health Benefits
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you will need to stop using antioxidant supplements, prebiotics, and probiotics.
What data supports the effectiveness of the treatment 'Olinda Valencia' and 'Rosy Red Valencia' sweet oranges for health benefits?
Research on similar sweet orange varieties, like Moro blood oranges, shows they can help with weight loss and reduce body fat in overweight individuals. These oranges contain compounds that may improve antioxidant and anti-inflammatory responses, which could contribute to their health benefits.12345
Is sweet orange juice safe for human consumption?
Research on different types of sweet orange juice, like Moro and red orange juice, shows no significant safety concerns for humans when consumed in typical amounts. However, people with certain health conditions, such as severe hypertension (high blood pressure) or those taking specific medications, should be cautious and consult a doctor before consuming.12467
How does the 'Olinda Valencia' sweet orange treatment differ from other treatments?
The 'Olinda Valencia' sweet orange treatment is unique because it contains high levels of carotenoids, such as lycopene and phytoene, which contribute to its strong antioxidant capacity. This makes it potentially beneficial for reducing oxidative stress, a feature not commonly emphasized in other treatments for similar conditions.12589
What is the purpose of this trial?
This study aims to evaluate the antioxidant and anti-inflammatory effects of acute and chronic consumption of two sweet orange (Citrus sinensis) varieties-'Rosy Red Valencia', which is rich in carotenoids such as lycopene, phytoene, and phytofluene, and 'Olinda Valencia', which lacks these carotenoids-in healthy adults. In this 4-week, randomized, parallel-arm clinical trial, participants will consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges daily. The study will assess the effects of sweet orange intake on markers of oxidative stress and inflammation, plasma carotenoid concentrations, gene expression in peripheral blood mononuclear cells, and gut health. Findings from this study may help identify potential health benefits associated with specific carotenoid profiles in sweet oranges and provide insights into their role in modulating inflammation and oxidative stress.
Research Team
Gerardo G Macknezie, PhD
Principal Investigator
Univeristy of California Davis
Eligibility Criteria
This trial is for healthy adults interested in participating in a study evaluating the health benefits of two types of sweet oranges. Participants will be required to consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges daily for 4 weeks.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Acute Phase
Participants consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges for 1 day to assess immediate effects
Chronic Phase
Participants consume either 'Rosy Red Valencia' or 'Olinda Valencia' oranges daily for 4 weeks to assess long-term effects
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- 'Olinda Valencia' sweet orange
- 'Rosy Red Valencia' sweet orange
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor