Cryotherapy for Muscle Cooling

(CRYO Trial)

Overseen By Eliott Arroyo, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Wake Forest University Health Sciences

Disqualifiers: Diabetes, Hypertension, Cancer, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

24 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The overall objective of this pilot study is to establish the feasibility and methodological validity of using high-density surface electromyography to characterize motor unit behavior of the quadriceps under thermoneutral and locally cooled conditions, and to generate preliminary data to inform the design of a larger, hypothesis-driven study.

Are You a Good Fit for This Trial?

This trial is for healthy individuals interested in participating in a study that examines the effects of cooling on thigh muscle activity. Specific eligibility details are not provided, but typically participants should have no underlying health conditions affecting their muscles.

Inclusion Criteria

I am a healthy adult with no major illnesses that could affect my safety or participation in the study.

I am between 18 and 35 years old.

Exclusion Criteria

I have or had a major metabolic disease like diabetes.

Pregnancy or breastfeeding

My thigh circumference is over 23 inches.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

1 visit (in-person)

Baseline Assessment and Familiarization

Informed consent, eligibility confirmation, baseline assessments, and familiarization procedures

1 day

1 visit (in-person)

Experimental Testing

Participants undergo experimental testing under thermoneutral and cooled conditions

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Cryotherapy

Trial Overview

The study tests how applying cold therapy (cryotherapy) to the quadriceps affects muscle function. Researchers will use advanced techniques to measure muscle responses under normal and cooled conditions, aiming to set up for future studies.

How Is the Trial Designed?

Group I: Sequence B Experimental Treatment 1 Intervention

Those randomized to Group B (n=12, 50% men) will perform the cooled condition first, followed by the thermoneutral condition.

Group II: Sequence A Experimental Treatment 1 Intervention

Those randomized to Group A (n=12, 50% men) will perform the thermoneutral condition first, followed by the cooled condition.

Who Is Running the Clinical Trial?

Wake Forest University Health Sciences

Lead Sponsor

Trials

1,432

Recruited

2,506,000+