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NAD+ precursor
NMN Supplementation for Metabolic Diseases (VAN Trial)
N/A
Recruiting
Led By Samuel Klein, MD
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Prediabetes defined as a 2-h oral glucose tolerance test plasma glucose of 140-199 mg/dL with or without a fasting plasma glucose of 100-125 mg/dL, or HbA1C ≥5.7.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before and after at least 16 weeks of treatment
Awards & highlights
VAN Trial Summary
This trial will see if NMN can help improve metabolism in people, as it has been shown to in rodents.
Who is the study for?
This trial is for adults with a BMI between 25.0-50.0 kg/m² who have prediabetes, indicated by certain blood sugar levels or insulin resistance scores. It's not open to women who are menstruating, people taking vitamin B3 supplements unless they stop them before and during the study, or those consuming more than two cups of coffee daily unless they can quit without withdrawal symptoms.Check my eligibility
What is being tested?
The study is testing if NMN (a compound that might improve metabolic functions) has positive effects on humans as it does in rodents. Participants will either receive NMN supplementation or a placebo to compare outcomes between the treated group and the control group.See study design
What are the potential side effects?
Potential side effects aren't specified here but generally could include reactions similar to other vitamin B3 forms such as skin flushing, nausea, liver toxicity at high doses, and low blood pressure.
VAN Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have prediabetes based on my glucose tolerance test or HbA1C levels.
VAN Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ before and after at least 16 weeks of treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before and after at least 16 weeks of treatment
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change in Muscle insulin sensitivity
Secondary outcome measures
Changes in glucose tolerance
VAN Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: NMN supplementationExperimental Treatment1 Intervention
At least 16 weeks of NMN.
Group II: PlaceboPlacebo Group1 Intervention
At least 16 weeks of placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Treatment
2013
Completed Phase 2
~13740
Find a Location
Who is running the clinical trial?
Washington University School of MedicineLead Sponsor
1,936 Previous Clinical Trials
2,299,634 Total Patients Enrolled
16 Trials studying Diabetes
5,242 Patients Enrolled for Diabetes
United States Department of DefenseFED
865 Previous Clinical Trials
327,643 Total Patients Enrolled
3 Trials studying Diabetes
311 Patients Enrolled for Diabetes
Samuel Klein, MDPrincipal InvestigatorWashington University School of Medicine
27 Previous Clinical Trials
2,165 Total Patients Enrolled
1 Trials studying Diabetes
101 Patients Enrolled for Diabetes
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have a body mass index (BMI) between 25 and 34.9.I drink more than 2 cups of coffee or similar daily or get headaches if I stop.I am a woman who still has menstrual periods.I have prediabetes based on my glucose tolerance test or HbA1C levels.I am not willing to stop taking vitamin B3 supplements for the study duration.
Research Study Groups:
This trial has the following groups:- Group 1: NMN supplementation
- Group 2: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who are the accepted participants in this research project?
"This experiment requires 56 participants aged between 45 and 75, with BMI measurements ranging from 25.0 to 34.9 kg/m² and a documented glucose metabolism disorder."
Answered by AI
Is this trial open to those beyond the age of four decades?
"The age bracket to be eligible for this trial is between 45 and 75. There are 29 clinical trials offering treatments exclusively to individuals below the age of 18, while 76 separate studies recruit patients above 65 years old."
Answered by AI
What is the current participant count of this medical experiment?
"Yes, according to public records on clinicaltrials.gov this medical trial is currently in the process of recruiting participants. It was first released on October 1st 2020 and most recently updated at the end of November 2021. The study requires 56 patients from a single site for their research."
Answered by AI
Are there opportunities for patients to join this clinical trial at present?
"Affirmative, the clinicaltrials.gov registry verifies that this medical trial is still open for enrollment. It was first made public on October 1st 2020 and has recently been updated as of November 30th 2021. The research initiative requires 56 volunteers to be recruited from a single location."
Answered by AI
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