56 Participants Needed

NMN Supplementation for Metabolic Diseases

(VAN Trial)

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Overseen BySamuel Klein, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Washington University School of Medicine

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this proposal is to determine whether the beneficial effects of NMN on metabolic function observed in rodents applies to people.

Who Is on the Research Team?

Samuel Klein, MD | Division of ...

Samuel Klein, MD

Principal Investigator

Washington University School of Medicine

Are You a Good Fit for This Trial?

This trial is for adults with a BMI between 25.0-50.0 kg/m² who have prediabetes, indicated by certain blood sugar levels or insulin resistance scores. It's not open to women who are menstruating, people taking vitamin B3 supplements unless they stop them before and during the study, or those consuming more than two cups of coffee daily unless they can quit without withdrawal symptoms.

Inclusion Criteria

You have a body mass index (BMI) between 25 and 34.9.
I have prediabetes based on my glucose tolerance test or HbA1C levels.
Prediabetes defined as fasting plasma glucose of ≥100 mg/dL, or HbA1C ≥5.7, or HOMA-IR ≥2.5.
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Exclusion Criteria

I drink more than 2 cups of coffee or similar daily or get headaches if I stop.
Unstable weight (>3% change during the last 2 months before entering the study)
I am a woman who still has menstrual periods.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive NMN supplementation or placebo for at least 16 weeks

16 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Placebo
  • Treatment
Trial Overview The study is testing if NMN (a compound that might improve metabolic functions) has positive effects on humans as it does in rodents. Participants will either receive NMN supplementation or a placebo to compare outcomes between the treated group and the control group.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: NMN supplementationExperimental Treatment1 Intervention
At least 16 weeks of NMN.
Group II: PlaceboPlacebo Group1 Intervention
At least 16 weeks of placebo.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Washington University School of Medicine

Lead Sponsor

Trials
2,027
Recruited
2,353,000+

United States Department of Defense

Collaborator

Trials
940
Recruited
339,000+
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