Systems Biology of Early Atopy
(SUNBEAM Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify prenatal and early life markers of high risk for food allergy and AD, as well as biological pathways (endotypes) that result in these conditions.Primary Objectives:* To study the role and interrelationships of established and novel clinical, environmental, biological, and genetic prenatal and early-life factors in the development and course of allergic diseases through age 3 years (or 6 years for those who choose to continue participation into SUNBEAM II), with an emphasis on atopic dermatitis and food allergy* To apply systems biology to identify mechanisms and biomarkers underlying the development of food allergy, atopic dermatitis, and their endotypes* To collect, process, and assay or store environmental and biological samples for current and future use in the study of allergic disease development
Who Is on the Research Team?
Corinne Keet, MD,MS,PhD
Principal Investigator
Div.of Pediatric Allergy, Immunology and Rheumatology, Dept. of Pediatrics, Johns Hopkins School of Medicine
Scott H. Sicherer, MD
Principal Investigator
Div. of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute,Dept. of Pediatrics, Icahn School of Medicine at Mount Sinai
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Enrollment and Baseline Assessment
Pregnant women, biological fathers, and offspring are enrolled; baseline biological and environmental samples are collected
Early Life Monitoring
Children are assessed for allergic diseases and samples are collected at specified intervals
Extended Monitoring
For participants opting to continue, additional assessments and sample collections occur
Follow-up
Participants are monitored for long-term outcomes related to allergic diseases
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Institute of Allergy and Infectious Diseases (NIAID)
Lead Sponsor
Consortium for Food Allergy Research
Collaborator
Rho Federal Systems Division, Inc.
Industry Sponsor