Magnesium Supplements for Exercise Performance

LB
CB
Overseen ByChristopher Bell, PhD

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether magnesium supplements can boost exercise performance, improve gut health, and enhance muscle function. Participants will take either a magnesium drink called ReMag or a placebo (a substance with no active ingredient) for nine days. Competitive cyclists who exercise at least five days a week and have done so for the past two years may be suitable candidates for this trial. As an unphased study, this trial offers a unique opportunity to contribute to scientific understanding and potentially enhance athletic performance.

Will I have to stop taking my current medications?

The trial requires that you stop using certain medications, such as laxatives, Zinc, diuretics, and proton pump inhibitors, especially if they contain magnesium or other substances that affect magnesium absorption.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that magnesium supplements are generally safe for most people when used as directed. Some studies suggest that magnesium, such as ReMag, can aid muscle recovery and reduce soreness, indicating it is usually well-tolerated.

However, one study warned that high doses of magnesium chloride, the type found in ReMag, can cause side effects. These may include low blood pressure, dizziness, or even an irregular heartbeat in severe cases. Following the recommended dosage is crucial to avoid these issues.

Overall, when used correctly, magnesium supplements like ReMag are considered safe. However, caution is always wise, and any unusual symptoms should be monitored.12345

Why are researchers excited about this trial?

ReMag is unique because it uses magnesium chloride in a liquid lemon-flavored drink to potentially enhance exercise performance. Unlike typical magnesium supplements, which are often in pill or powder form, ReMag offers a more palatable liquid option that may be absorbed more efficiently by the body. Researchers are excited about ReMag because it could show benefits in just nine days, promising a quicker boost in exercise performance compared to other magnesium supplements that might take longer to exhibit effects.

What evidence suggests that magnesium supplements might be an effective treatment for exercise performance?

This trial will compare the effects of ReMag, a magnesium supplement, with a placebo on exercise performance. Research has shown that magnesium supplements like ReMag might improve exercise performance by correcting magnesium deficiency, which can affect muscle function and energy levels. However, some studies suggest that short-term magnesium supplementation might slightly reduce exercise performance, such as lowering VO2max and decreasing average power during intense workouts. Conversely, other research indicates that magnesium can lessen muscle soreness and aid recovery, possibly protecting muscles from damage. While magnesium may offer benefits, its effects can vary based on the situation and type of exercise.16789

Are You a Good Fit for This Trial?

This trial is for adults aged 18-40 who regularly exercise, specifically competitive cyclists with a 'Good' VO2max rating. It's not for those who've taken magnesium supplements recently, are pregnant or breastfeeding, can't do vigorous exercise, have kidney disease, or use certain medications like laxatives and heartburn treatments.

Inclusion Criteria

Maximal oxygen uptake (VO2max) satisfying the minimum criteria for "Good" (sex- and age-adjusted) as defined by the American College of Sports Medicine.
Competitive cyclists

Exclusion Criteria

Pregnancy or breast-feeding
Identification of a contra-indication to exercise during a 12-lead exercise stress test
Use of a magnesium supplement within the previous 4 weeks
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a magnesium supplement or placebo for 9 days to assess its effects on performance, gut microbiota, and muscle function

9 days

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Placebo
  • ReMag
Trial Overview The study is testing whether a short-term dietary supplement of magnesium (ReMag) can boost exercise performance, improve gut health by changing the microbiome, and enhance muscle function in mitochondria compared to a placebo.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: ReMagExperimental Treatment1 Intervention
Group II: ReMag PlaceboPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Christopher Bell

Lead Sponsor

Trials
9
Recruited
230+

Published Research Related to This Trial

Recent evidence from 10 studies, including 5 meta-analyses and 5 randomized controlled trials, suggests that magnesium (Mg) supplementation above the current tolerable upper intake level (UL) of 350 mg/d does not significantly increase the risk of diarrhea in adults.
The analysis indicates that higher doses of magnesium (up to 1200 mg/d) can be safely consumed without major gastrointestinal adverse events, supporting the idea that the UL for magnesium should be re-evaluated to potentially allow for greater supplementation and reduce undernutrition.
Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults.Costello, R., Rosanoff, A., Nielsen, F., et al.[2023]

Citations

Short-Term Magnesium Supplementation Has Modest ...Short-term magnesium supplementation has modest detrimental effects on cycle ergometer exercise performance and skeletal muscle mitochondria.
Magnesium Supplements for Exercise PerformanceReMag is a magnesium supplement that may help improve exercise performance by addressing magnesium deficiency, which can impair muscle function and energy ...
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/40077784/
Short-Term Magnesium Supplementation Has Modest ...Magnesium supplementation had modest ergolytic effects on cycle ergometer exercise performance and mitochondrial respiration.
Can supplementation with magnesium negatively affect ...Magnesium decreased VO2max (44.4 vs. 41.3 mL/kg/min) and average power output, measured during a 30-second sprint (439 vs. 415 watts), compared ...
Effects of magnesium supplementation on muscle soreness in ...Results. These studies showed that MgS reduced muscle soreness, improved performance, recovery and induced a protective effect on muscle damage.
Effects of magnesium supplementation on muscle ...Results. These studies showed that MgS reduced muscle soreness, improved performance, recovery and induced a protective effect on muscle damage.
ReMag for Sport - Magnesium for AthletesReMag® for Sport is a dietary supplement with picometer-sized magnesium ions, suitable for elite athletes and people with an active lifestyle.
Ergogenic Properties of Magnesium SupplementationThe purpose of the proposed project is to determine if short-term dietary supplementation of magnesium will improve performance during a series of lab-based ...
What are the side effects of Magnesium chloride?High doses can cause a drop in blood pressure, leading to dizziness, fainting, and in severe cases, an irregular heartbeat or heart attack.
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