Magnesium Supplements for Exercise Performance

Overseen By Christopher Bell, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Christopher Bell

Must not be taking: Laxatives, Zinc, Diuretics, others

Disqualifiers: Pregnancy, Kidney disease, others

Compensation: Varies

Number of Visits: Unknown

Duration: 9 days

41 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial is testing if taking magnesium supplements can help athletes perform better in exercise tests. The study focuses on endurance-trained adults because they are likely to benefit the most. Magnesium is important for many body functions, and the researchers want to see if it can also improve gut health and muscle function. Magnesium is involved in numerous processes that affect muscle function including oxygen uptake, energy production, and electrolyte balance.

Will I have to stop taking my current medications?

The trial requires that you stop using certain medications, such as laxatives, Zinc, diuretics, and proton pump inhibitors, especially if they contain magnesium or other substances that affect magnesium absorption.

What data supports the effectiveness of the treatment ReMag for exercise performance?

Research shows that magnesium, a key component of ReMag, is important for muscle function and energy production. Studies indicate that magnesium supplementation can improve exercise performance in individuals with magnesium deficiency and may enhance muscle performance and exercise tolerance. ^{1 2 3 4 5}

Is magnesium supplementation safe for humans?

Magnesium supplements are generally safe for humans, but high doses can cause diarrhea. Studies show that doses above the current recommended limit can be consumed without significant adverse effects, although some people may experience minor gastrointestinal issues. ^{1 2 6 7 8}

How does the treatment ReMag differ from other magnesium supplements for exercise performance?

ReMag is a magnesium supplement that may help improve exercise performance by addressing magnesium deficiency, which can impair muscle function and energy metabolism. Unlike other treatments, ReMag focuses on replenishing magnesium levels to support muscle performance, especially in individuals with low magnesium intake or increased physical activity. ^{1 2 4 9 10}

Eligibility Criteria

This trial is for adults aged 18-40 who regularly exercise, specifically competitive cyclists with a 'Good' VO2max rating. It's not for those who've taken magnesium supplements recently, are pregnant or breastfeeding, can't do vigorous exercise, have kidney disease, or use certain medications like laxatives and heartburn treatments.

Inclusion Criteria

Adult males and females (18 - 40 years, inclusive) who have exercised a minimum of 5 days per week, for a minimum of 30-minutes/session, during the previous 2 years.

Maximal oxygen uptake (VO2max) satisfying the minimum criteria for "Good" (sex- and age-adjusted) as defined by the American College of Sports Medicine.

Competitive cyclists

Exclusion Criteria

Pregnancy or breast-feeding

Identification of a contra-indication to exercise during a 12-lead exercise stress test

Use of a magnesium supplement within the previous 4 weeks

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a magnesium supplement or placebo for 9 days to assess its effects on performance, gut microbiota, and muscle function

9 days

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Placebo
• ReMag

Trial Overview The study is testing whether a short-term dietary supplement of magnesium (ReMag) can boost exercise performance, improve gut health by changing the microbiome, and enhance muscle function in mitochondria compared to a placebo.

Participant Groups

Group I: ReMag Experimental Treatment 1 Intervention

Liquid Lemon flavor drink containing 300 mg magnesium chloride (Regmag) consumed twice daily for 9 days

Group II: ReMag Placebo Placebo Group 1 Intervention

Liquid Lemon flavor drink placebo comparator consumed twice daily for 9 days.

Who Is Running the Clinical Trial?

Christopher Bell

Lead Sponsor

Trials

9

Recruited

230+

Findings from Research

Recent evidence from 10 studies, including 5 meta-analyses and 5 randomized controlled trials, suggests that magnesium (Mg) supplementation above the current tolerable upper intake level (UL) of 350 mg/d does not significantly increase the risk of diarrhea in adults.

The analysis indicates that higher doses of magnesium (up to 1200 mg/d) can be safely consumed without major gastrointestinal adverse events, supporting the idea that the UL for magnesium should be re-evaluated to potentially allow for greater supplementation and reduce undernutrition.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. Costello, R., Rosanoff, A., Nielsen, F., et al.[2023]

References

1. England pubmed.ncbi.nlm.nih.gov

Update on the relationship between magnesium and exercise. [2022]

2. United States pubmed.ncbi.nlm.nih.gov

Magnesium and exercise. [2019]

3. United States pubmed.ncbi.nlm.nih.gov

The effects of magnesium supplementation on exercise performance. [2019]

4. Switzerland pubmed.ncbi.nlm.nih.gov

Can Magnesium Enhance Exercise Performance? [2019]

5. United States pubmed.ncbi.nlm.nih.gov

Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. [2022]

6. United States pubmed.ncbi.nlm.nih.gov

Oral magnesium supplementation in adults with coronary heart disease or coronary heart disease risk. [2013]

7. United States pubmed.ncbi.nlm.nih.gov

Perspective: Call for Re-evaluation of the Tolerable Upper Intake Level for Magnesium Supplementation in Adults. [2023]

8. United States pubmed.ncbi.nlm.nih.gov

Decrease in Ionized and Total Magnesium Blood Concentrations in Endurance Athletes Following an Exercise Bout Restores within Hours-Potential Consequences for Monitoring and Supplementation. [2017]

9. Switzerland pubmed.ncbi.nlm.nih.gov

[Magnesium and exercise]. [2013]

10. United States pubmed.ncbi.nlm.nih.gov

The effect of acute magnesium loading on the maximal exercise performance of stable chronic obstructive pulmonary disease patients. [2023]