Aerobic Exercise for Breast Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial investigates whether a supervised exercise program can benefit people with early-stage triple-negative breast cancer (TNBC) who receive certain cancer treatments before surgery. Participants will engage in an aerobic exercise program to determine if it improves their health and treatment outcomes. This trial suits those who can walk independently, have stage 2 or 3 TNBC, and are undergoing specific cancer therapies.
As an unphased trial, it provides a unique opportunity to explore potential health benefits from exercise during treatment.
Do I have to stop taking my current medications for the trial?
The trial requires that you do not take medications known to influence immune function, like certain corticosteroids or beta blockers. If you're on these medications, you may need to stop them to participate.
What prior data suggests that this exercise program is safe for participants with early-stage TNBC?
Research shows that aerobic exercise is generally safe for breast cancer patients. Studies have found that women who remain active, even after cancer treatment, often experience fewer cancer recurrences and lower death rates. This suggests that exercise might not only be safe but could also enhance overall health. Additionally, aerobic exercise is associated with a better quality of life and increased participation in physical activities for breast cancer survivors. Overall, these findings suggest that aerobic exercise is a safe and potentially beneficial practice for those undergoing breast cancer treatment.12345
Why are researchers excited about this trial?
Researchers are excited about the aerobic exercise program for breast cancer patients because it offers a non-invasive and drug-free approach to improving health outcomes. Unlike standard treatments such as chemotherapy, radiation, or hormone therapy, which can have significant side effects, this exercise regimen aims to enhance cardiorespiratory fitness and overall well-being through physical activity. The program consists of just four in-clinic sessions, making it potentially more accessible and less burdensome than ongoing medical treatments. This approach could complement existing therapies, offering a holistic strategy that supports physical health without adding to the treatment burden.
What evidence suggests that this exercise program is effective for early-stage TNBC?
Research has shown that aerobic exercise can be a helpful addition to treatment for breast cancer patients, including those with early-stage triple-negative breast cancer (TNBC). Studies have found that regular exercise greatly improves quality of life, reduces cancer-related fatigue, and enhances physical abilities in breast cancer patients. Exercise also boosts heart and lung fitness, which is crucial for overall health and recovery. In this trial, participants will engage in an acute cardiorespiratory exercise program consisting of four in-clinic exercise sessions. The benefits of exercise as a supportive treatment are well-documented, making it a promising option for improving outcomes in breast cancer care.16789
Who Is on the Research Team?
Jasmine Sukumar, MD
Principal Investigator
M.D. Anderson Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults with early-stage Triple Negative Breast Cancer (TNBC) who can exercise and are about to receive chemo-immunotherapy. They must be able to walk, have an ECOG status of 0-1, and not be on other clinical trials or certain medications that affect immune function. Pregnant individuals or those with recent serious health issues like heart attacks are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo a supervised cardiorespiratory exercise program alongside immune checkpoint inhibitor therapy
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Exercise
Trial Overview
The study tests if a supervised aerobic exercise program benefits patients with TNBC undergoing Immune Checkpoint Inhibitor (ICI) therapy before breast surgery. It aims to see if exercise can improve treatment outcomes.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
consisting of 4 in-clinic exercise sessions
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
Citations
Effects of Aerobic Exercise on Cardiorespiratory Fitness and ...
This study sought to examine the effects of aerobic exercise in anthracycline-treated long-term survivors of breast cancer (BCS) and to compare the effects to ...
2.
cardiooncologyjournal.biomedcentral.com
cardiooncologyjournal.biomedcentral.com/articles/10.1186/s40959-024-00235-zEffectiveness of exercise modalities on breast cancer patient ...
Overall exercise significantly improves the HRQOL, CRF and physical function in patients with BC. HRQOL was improved with all exercise types.
Implementing exercise and self-management for women ...
Multiple studies demonstrate that exercise is a beneficial adjunctive treatment for individuals with BC, positively impacting both physical and ...
Effectiveness of exercise-based interventions in preventing ...
Exercise in breast cancer patients has primarily been reported for its impact on cardiorespiratory fitness, neglecting its potential effectiveness in improving ...
5.
sportsmedicine-open.springeropen.com
sportsmedicine-open.springeropen.com/articles/10.1186/s40798-025-00872-3Comparative Efficacy of Different Exercise Therapies for ...
Exercise has a significantly positive impact on the CRF of breast cancer survivors. MICT, M–V, HIIT, and M–V + RE had better efficacy than usual ...
Outcomes of physical exercises on initiation, progression, and ...
Evidence has suggested that participation in physical activity is correlated with a decrease in reappearance and fatality rates of breast cancer patients.
Exercise and Survival for Women with Breast Cancer - NCI
Women who engaged in regular physical activity before their cancer diagnosis and after treatment were less likely to have their cancer come back ...
Exercise Communication for Breast Cancer Survivors
Exercise communication was associated with favorable outcomes, including increased exercise participation and quality of life among breast cancer survivors.
9.
thecardiologyadvisor.com
thecardiologyadvisor.com/news/aerobic-exercise-minimally-improves-cardiorespiratory-fitness-in-breast-cancer-survivors/Aerobic Exercise Minimally Improves Cardiorespiratory ...
Aerobic exercise minimally improves cardiorespiratory fitness among breast cancer survivors who were treated with anthracycline.
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