Platelet-Rich Fibrinogen for Toothlessness

Overseen By Amy C Killeen, DDS, MS

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: University of Nebraska

Must not be taking: NSAIDs, Methotrexate, Bisphosphonates

Disqualifiers: Smoking, Pregnancy, Systemic conditions, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 4

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to explore how well platelet-rich fibrin (PRF) aids healing after the extraction of a back tooth. Researchers are particularly interested in the treatment's effects on both younger individuals (ages 14-18) and older adults (ages 50-80). Half of the participants will receive PRF treatment, while the other half will not, allowing for a comparison. This study may suit those needing a back tooth removed and who are patients at the University of Nebraska Medical Center's College of Dentistry. As an unphased trial, it offers participants the opportunity to contribute to groundbreaking research that could enhance dental healing processes.

Will I have to stop taking my current medications?

If you are taking medications like NSAIDs, methotrexate, or bisphosphonates, you may need to stop, as these drugs can delay wound healing. The trial does not specify a washout period, but it's important to discuss your current medications with the study team.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

A previous study found that using platelet-rich fibrin (PRF) in surgical areas after tooth extractions reduced pain and bleeding. Another study showed that PRF can prevent infections and reported no unusual side effects. Research has also found that PRF can stop bleeding after surgery and prevent other complications. Overall, PRF appears well-tolerated and safe for use in dental procedures. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Platelet-rich fibrin (PRF) is unique because it uses a natural concentration of growth factors derived from the patient's own blood to aid in healing after tooth extraction. Unlike traditional methods that might rely on synthetic materials or medications to promote gum and bone recovery, PRF is a minimally invasive approach that can enhance tissue regeneration. Researchers are excited about this technique because it not only reduces the risk of rejection and infection but also accelerates the healing process by delivering a high concentration of healing proteins directly to the site of extraction. This personalized approach could transform post-extraction care, especially for younger and older patients who may have varying healing capabilities.

What evidence suggests that platelet-rich fibrin could be effective for oral wound healing?

Studies have shown that platelet-rich fibrin (PRF) greatly improves soft tissue healing after tooth extractions. Research indicates that PRF reduces swelling and pain, leading to less need for painkillers. It also helps prevent dry sockets, a common issue after tooth removal, especially in the first week. Additionally, about two-thirds of studies found that PRF reduces pain in the first few days after surgery. In this trial, some participants will receive PRF treatment after tooth extraction, while others will not, allowing for a comparison of recovery outcomes. Overall, PRF aids recovery after dental procedures by speeding up healing and reducing discomfort. ^{6 7 8 9 10}

Who Is on the Research Team?

Amy C Killeen, DDS, MS

Principal Investigator

University of Nebraska

Are You a Good Fit for This Trial?

This trial is for individuals who need a posterior tooth extraction. It includes two age groups: young people aged 14-18 and older adults aged 50-80. Participants must be healthy enough to undergo the procedure, but specific inclusion and exclusion criteria are not provided.

Inclusion Criteria

Patient at University of Nebraska Medical Center (UNMC) College of Dentistry

Able and willing to provide consent/assent

I need a back tooth removed.

Exclusion Criteria

Systemic conditions that delay wound healing

Smoking and vaping

Pregnancy

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

Treatment

Participants undergo posterior tooth extraction and receive platelet-rich fibrinogen (PRF) treatment or no treatment

1 day

1 visit (in-person)

Post-operative Follow-up

Participants return for suture removal and evaluation of healing site, with additional soft tissue sampling

2 weeks

1 visit (in-person)

Final Follow-up

Participants return for a final post-operative radiograph and assessment of bone density for implant planning

3 months

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Platelet-rich fibrin (PRF)

Trial Overview The study is testing the effects of platelet-rich fibrinogen (PRF) on healing after tooth extraction in different age groups. Half of the participants will receive PRF in their extraction socket, while all will have tissue samples taken at various stages for analysis.

How Is the Trial Designed?

Group I: Young Participants Treated with Platelet-rich Fibrinogen Active Control 1 Intervention

Participants aged 14 to 18 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Group II: Aged Participants Treated with Platelet-rich Fibrinogen Active Control 1 Intervention

Participants aged 50 to 80 years of age will receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Group III: Aged Control Active Control 1 Intervention

Participants aged 50 to 80 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Group IV: Young Control Active Control 1 Intervention

Participants aged 14 to 18 years of age will not receive Platelet-rich Fibrinogen (PRF) treatment after tooth extraction.

Who Is Running the Clinical Trial?

University of Nebraska

Lead Sponsor

Trials

563

Recruited

1,147,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11519305/

Effectiveness of platelet-rich fibrin in third molar extractions PRF affects the long-term outcomes of third molar removal by reducing swelling and reducing as well as shortening painkiller consumption.

2. bmcoralhealth.biomedcentral.com bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-025-06238-1

The efficacy of platelet-rich fibrin (PRF) in post-extraction hard ... The analysis showed that PRF significantly improved soft tissue healing and reduced the incidence of AO. While PRF helped reduce pain, the ...

3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8684569/

Efficacy of platelet-rich fibrin in promoting the healing of ... 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft ...

4. sciencedirect.com sciencedirect.com/science/article/pii/S1658361221000421

The effects of platelet-rich fibrin on post-surgical ... Based on the outcomes of our study, implanting PRF into surgical extraction sites can be helpful in reducing postoperative pain and improving soft tissue ...

5. onlinelibrary.wiley.com onlinelibrary.wiley.com/doi/10.1155/2021/6686857

The Effectiveness of Advanced Platelet‐Rich Fibrin in ... Three recent systematic reviews showed a beneficial effect of PRF in preventing dry sockets within the first seven days. Meta-analysis found ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8348291/

The effects of platelet-rich fibrin on post-surgical complications ... Based on the outcomes of this study, implanting PRF into surgical extraction sites seems to reduce postoperative pain and bleeding and improve ...

7. sciencedirect.com sciencedirect.com/science/article/pii/S2212555820300235

Investigation of the analgesic effect of platelet-rich fibrin on ... In addition, when PRF is applied, it can be expected to prevent infection after tooth extraction. In this study, no abnormal findings were noted on either side ...

8. clinicaltrials.gov clinicaltrials.gov/study/NCT07011303?term=%22oral+health%22

Investigation of the Effect of Horizontal Platelet Rich Fibrin ... The research hypothesis is that H-PRF will contribute positively to the healing of tooth extraction sockets. Detailed Description. This study was planned as a ...

9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11467017/

Platelet-rich fibrin as a hemostatic agent in dental ... The aim of this systematic review was to evaluate whether platelet-rich-fibrin (PRF) is effective in preventing postoperative bleeding after ...

10. joms.org joms.org/article/S0278-2391(17)30611-0/fulltext

Local Application of Platelet-Rich Fibrin During Lower ... The results of this study confirm the hypothesis that local application of PRF during lower third molar extraction prevents postoperative complications. PRF ...