Platelet-Rich Fibrinogen for Toothlessness
Trial Summary
Will I have to stop taking my current medications?
If you are taking medications like NSAIDs, methotrexate, or bisphosphonates, you may need to stop, as these drugs can delay wound healing. The trial does not specify a washout period, but it's important to discuss your current medications with the study team.
What data supports the effectiveness of the treatment Platelet-rich fibrin (PRF) for toothlessness?
Is Platelet-Rich Fibrin (PRF) safe for use in humans?
How is the treatment Platelet-rich fibrin (PRF) unique for toothlessness?
Platelet-rich fibrin (PRF) is unique because it uses a natural concentration of platelets and growth factors from the patient's own blood to promote healing and regeneration, without the need for added chemicals or drugs. This makes it a safe and effective option for improving bone and tissue regeneration in dental applications, such as addressing toothlessness.347910
What is the purpose of this trial?
The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.
Research Team
Amy C Killeen, DDS, MS
Principal Investigator
University of Nebraska
Eligibility Criteria
This trial is for individuals who need a posterior tooth extraction. It includes two age groups: young people aged 14-18 and older adults aged 50-80. Participants must be healthy enough to undergo the procedure, but specific inclusion and exclusion criteria are not provided.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo posterior tooth extraction and receive platelet-rich fibrinogen (PRF) treatment or no treatment
Post-operative Follow-up
Participants return for suture removal and evaluation of healing site, with additional soft tissue sampling
Final Follow-up
Participants return for a final post-operative radiograph and assessment of bone density for implant planning
Treatment Details
Interventions
- Platelet-rich fibrin (PRF)
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Nebraska
Lead Sponsor