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Brain Stimulation for Memory Impairments in Epilepsy. If epilepsy is not related to this particular study of memory impairments, then a more general title would be needed such as: Brain Stimulation for Memory Impairments

N/A
Waitlist Available
Led By Michael Kahana, PhD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects expected to undergo intracranial electroencephalographic monitoring as part of treatment for pharmacologically resistant epilepsy.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 4 weeks (typical duration of hospital stay)
Awards & highlights

Study Summary

This trial will study the effects of electrical brain stimulation on memory in patients with memory impairments.

Who is the study for?
This trial is for individuals with drug-resistant epilepsy who are already scheduled to have brain monitoring. Participants should be able to perform memory tests and give informed consent. It's not suitable for those with cognitive or physical disabilities affecting task performance, psychiatric conditions impacting consent, other serious medical issues, or pregnant women.Check my eligibility
What is being tested?
The study uses direct electrical brain stimulation during verbal and spatial memory tasks to understand how the brain processes memories. This research involves multiple sites working together and participants will undergo experiments while being monitored.See study design
What are the potential side effects?
While the description doesn't list specific side effects, direct electrical stimulation of the brain may cause discomfort at the stimulation site, temporary changes in mood or memory function, headaches, or seizures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for brain monitoring due to hard-to-treat epilepsy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 4 weeks (typical duration of hospital stay)
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 4 weeks (typical duration of hospital stay) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Electrocorticogram
Intracranial electrophysiological recordings: Intracranial Electroencephalogram (iEEG), Synchrony
Intracranial electrophysiological recordings: Unit Activity, Firing Rate
+2 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Direct Electrical StimulationExperimental Treatment1 Intervention
Stimulation will be applied concurrently with the task, if applicable, and stimulation trials will be interleaved with sham trials, where no stimulation is delivered.

Find a Location

Who is running the clinical trial?

Columbia UniversityOTHER
1,431 Previous Clinical Trials
2,460,581 Total Patients Enrolled
9 Trials studying Epilepsy
2,717 Patients Enrolled for Epilepsy
Dartmouth CollegeOTHER
79 Previous Clinical Trials
1,415,324 Total Patients Enrolled
1 Trials studying Epilepsy
175 Patients Enrolled for Epilepsy
University of FreiburgOTHER
56 Previous Clinical Trials
23,873 Total Patients Enrolled

Media Library

Direct electrical stimulation Clinical Trial Eligibility Overview. Trial Name: NCT04286776 — N/A
Epilepsy Research Study Groups: Direct Electrical Stimulation
Epilepsy Clinical Trial 2023: Direct electrical stimulation Highlights & Side Effects. Trial Name: NCT04286776 — N/A
Direct electrical stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04286776 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can you provide details regarding the locations in Canada offering this trial?

"There are 5 medical centres engaging in this research endeavour, including Emory University Hospital (Atlanta), Thomas Jefferson University Hospital (Philadelphia), and Dartmouth-Hitchcock Medical Center (Lebanon)."

Answered by AI

Are there any available slots for this clinical research endeavor?

"This medical research project, which was initially listed on September 23rd 2019, is in the process of recruiting participants. The study's most recent update dates back to December 2nd 2021 as per clinicaltrials.gov records."

Answered by AI

What is the current quota for enrolling participants in this research?

"The clinical trial necessitates a total of 250 qualified participants. These individuals can participate across multiple sites, such as Emory University Hospital in Atlanta and Thomas Jefferson University Hospital in Philadelphia."

Answered by AI

To what demographic does the recruitment criteria for this research apply?

"This experimental trial is accepting 250 participants between 18 and 65 with drug resistant epilepsy. Required criteria to qualify for the study necessitates that the patient must undergo intracranial electroencephalographic monitoring as part of their treatment plan for pharmacologically resistant epilepsy."

Answered by AI

Is this experimental research open to participants of all ages?

"This medical trial has an age restriction of 18 to 65 years old. Applicants younger than 18 are encouraged to check out the 19 alternative trials while those over 65 should explore one of the 29 other options available."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Using Direct Brain Stimulation to Study Cognitive Electrophysiology
2019. "Using Direct Brain Stimulation to Study Cognitive Electrophysiology". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04286776.
~9 spots leftby Jun 2024
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