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Surgery

Surgical Treatment of drug resistantepilepsy for Epilepsy

N/A
Recruiting
Led By Kareem A Zaghloul, M.D.
Research Sponsored by National Institute of Neurological Disorders and Stroke (NINDS)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
1. Be 8 years of age or older with drug resistant epilepsy or tumor related epilepsy.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 year
Awards & highlights

Study Summary

This trial is for people with medically intractable epilepsy that haven't responded to medication, in order to see if surgery can help.

Eligible Conditions
  • Epilepsy
  • Temporal Lobe Epilepsy

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Descriptive and/or correlational studies
Secondary outcome measures
6. Neurophysiological correlates of human cognitive function and to provide invasive monitoring for patients with tumor related epilepsy
Mean Engel Class one year after surgery stratified by the type of surgical procedure
Cognition
+3 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: 1Experimental Treatment1 Intervention
Patients 8 years of age or older with drug resistant epilepsy or tumor related epilepsy

Find a Location

Who is running the clinical trial?

National Institute of Neurological Disorders and Stroke (NINDS)Lead Sponsor
1,340 Previous Clinical Trials
649,059 Total Patients Enrolled
77 Trials studying Epilepsy
24,653 Patients Enrolled for Epilepsy
Kareem A Zaghloul, M.D.Principal InvestigatorNational Institute of Neurological Disorders and Stroke (NINDS)
7 Previous Clinical Trials
531 Total Patients Enrolled
3 Trials studying Epilepsy
331 Patients Enrolled for Epilepsy

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
eLifeJournal
Activity-dependent Tuning of Intrinsic Excitability in Mouse and Human Neurogliaform Cells
Chittajallu, Ramesh, Kurt Auville, Vivek Mahadevan, Mandy Lai, Steven Hunt, Daniela Calvigioni, Kenneth A Pelkey, Kareem A Zaghloul, and Chris J McBain. 2020. “Activity-dependent Tuning of Intrinsic Excitability in Mouse and Human Neurogliaform Cells”. Elife. eLife Sciences Publications, Ltd. doi:10.7554/elife.57571.
clinicaltrials.govStudy
Surgery as a Treatment for Medically Intractable Epilepsy
2011. "Surgery as a Treatment for Medically Intractable Epilepsy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01273129.
~21 spots leftby Apr 2025
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