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Behavioural Intervention

rTMS Active for Parkinson's Disease

N/A

Recruiting

Led By Mariya V Cherkasova, PhD

Research Sponsored by West Virginia University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

On dopamine-replacement therapy

A Montreal Cognitive Assessment (MoCA) score of 20 or higher

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 1 hour following the intervention

Awards & highlights

Study Summary

This trial aims to study the effects of a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) on patients with Parkinson's Disease who have impulse control disorders. The

Who is the study for?

This trial is for Parkinson's Disease patients who struggle with impulse control disorders. Participants will undergo two types of brain stimulation sessions: real and pretend (sham). They must be able to complete tasks and questionnaires after each session, which are spaced 1-2 weeks apart.Check my eligibility

What is being tested?

The study tests if repetitive transcranial magnetic stimulation (rTMS) on a specific brain area can help manage impulse control in Parkinson's patients. It's a cross-over trial where everyone gets both the actual treatment and a fake one at different times.See study design

What are the potential side effects?

While not specified here, rTMS may cause discomfort at the stimulation site, headache, lightheadedness or seizures in rare cases. However, it is generally considered safe with minimal side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am on medication to increase dopamine levels.

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My cognitive function is relatively preserved.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 1 hour following the intervention

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 1 hour following the intervention

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 1 hour following the intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Delay-Discounting

Change in Reinforcement Learning

Secondary outcome measures

Change in impulse control disorder symptoms

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: rTMS ActiveActive Control1 Intervention

the participant will receive a type of TMS called repetitive TMS (rTMS) wherein the magnetic pulses delivered will be close together in a rapid sequence over the dlPFC. Participants receive excitatory rTMS with a stimulation frequency of 20 Hz between 100-120% of their resting motor threshold.

Group II: rTMS ShamPlacebo Group1 Intervention

Sham rTMS will be the same as real rTMS, except a special sham coil will be used, which produces the same sensation on the scalp of the patients as the real coil but delivers no magnetic stimulation to the brain.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

West Virginia UniversityLead Sponsor

177 Previous Clinical Trials

62,194 Total Patients Enrolled

Mariya V Cherkasova, PhDPrincipal InvestigatorWest Virginia University

1 Previous Clinical Trials

20 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment phase of this medical study currently ongoing?

"As per clinicaltrials.gov, this specific research endeavor is currently not in recruitment phase. The trial was introduced on February 1st, 2024 and last modified on January 31st, 2024. While this particular study no longer seeks participants, there are a total of 507 ongoing trials that are actively enrolling individuals at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

Mariya V. Cherkasova 2024. "rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06237868.

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