Cognitive Behavioural Therapy for Psychosis
(EPIC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how Cognitive Behavioural Therapy for psychosis (CBTp) affects the brain and thinking skills in individuals with conditions like schizophrenia. Researchers will use electroencephalography (EEG) to study brain activity and assess cognitive improvements over four months of therapy. The treatment includes weekly, one-hour, in-person sessions with a psychologist or trained graduate student. This trial is for individuals diagnosed with schizophrenia, schizoaffective disorder, or another psychotic disorder who are currently experiencing active psychosis symptoms. As an unphased study, this trial offers a unique opportunity to contribute to understanding how CBTp can enhance brain function and thinking skills.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that Cognitive Behavioural Therapy for Psychosis is safe?
Research shows that Cognitive Behavioural Therapy for psychosis (CBTp) is well-tolerated. Studies have found that CBTp is a common and trusted treatment in many Western countries, meaning professionals widely use it. While CBTp doesn't usually have specific side effects, it involves talking and working through thoughts with a trained therapist, which is generally safe for participants.
CBTp doesn't have the side effects that medications might have because it is a type of talk therapy. It focuses on changing thinking patterns to help manage symptoms.
For those considering joining a trial involving CBTp, evidence suggests it's a safe option. It helps people manage their symptoms without the risks associated with many drug treatments.12345Why are researchers excited about this trial?
Cognitive Behavioural Therapy for Psychosis (CBTp) is unique because it provides a structured, manual-based approach specifically tailored for individuals experiencing psychosis, which is not typical of the usual medication-based treatments. Unlike antipsychotic medications that primarily address symptoms at a biochemical level, CBTp targets the psychological processes contributing to psychotic experiences, helping patients develop coping strategies and reduce distress. Researchers are excited about this treatment because it offers a complementary approach that enhances standard care without altering it, potentially leading to more holistic and sustainable outcomes for patients.
What evidence suggests that Cognitive Behavioural Therapy for Psychosis is effective for treating psychosis?
Research shows that Cognitive Behavioural Therapy for Psychosis (CBTp), which participants in this trial will receive, can help reduce symptoms of psychosis. Studies indicate that CBTp improves both general symptoms and specific ones like hallucinations and delusions. A review of several studies found small to medium improvements in these symptoms, with more noticeable benefits over time, especially for delusions. Another study suggested that CBTp reduces symptoms more effectively than other treatments. Overall, this evidence suggests that CBTp can be a helpful addition to regular care for people with psychosis.24678
Who Is on the Research Team?
Michael W Best, Ph.D.
Principal Investigator
University of Toronto
Are You a Good Fit for This Trial?
This trial is for adults aged 18-65 who are currently experiencing symptoms of psychosis, including those with schizophrenia or schizoaffective disorder. Participants must be able to read and speak English and not have a history of drug or alcohol abuse. People with physical disabilities that prevent assessment participation, neurological diseases, significant medical illnesses affecting brain function, or a history of severe head injury cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Cognitive Behavioural Therapy for psychosis (CBTp) in individual sessions with a psychologist for 1-hour per week for 6 months
Follow-up
Participants are monitored for neurophysiological and neurocognitive outcomes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cognitive Behavioural Therapy for Psychosis
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Toronto
Lead Sponsor
Ontario Shores Centre for Mental Health Sciences
Collaborator