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Cognitive Behavioural Therapy for psychosis for Psychosis (EPIC Trial)

N/A

Recruiting

Led By Michael W Best, Ph.D.

Research Sponsored by University of Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline to follow-up (6 months post treatment)

Awards & highlights

EPIC Trial Summary

This trial studies the effects of CBTp on neurophysiological and neurocognitive factors in those with psychosis. 20 participants will receive the therapy and be assessed.

Eligible Conditions

Psychosis
Schizophrenia

EPIC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline to follow-up (6 months post treatment)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline to follow-up (6 months post treatment)

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to follow-up (6 months post treatment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Positive and Negative Syndrome Scale (PANSS) Total Score

Secondary outcome measures

Beliefs About Paranoia Scale (BAPS)

Beliefs About Voices Questionnaire (BAVQ)

Brief Core Schema Scale (BCSS)

+10 more

EPIC Trial Design

1Treatment groups

Experimental Treatment

Group I: Cognitive Behavioural Therapy for psychosisExperimental Treatment1 Intervention

CBTp will be delivered according to an established manual that the PI has previously used successfully for in-person treatment. Treatment will consist of individual sessions with a psychologist employed by the University of Toronto for 1-hour per week for 6-months, or by one of the listed clinical graduate students under his supervision. All treatment will be delivered in-person. This treatment will be delivered in addition to usual care and no changes to usual care will be required.

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Find a Location

Who is running the clinical trial?

University of TorontoLead Sponsor

689 Previous Clinical Trials

1,018,623 Total Patients Enrolled

2 Trials studying Psychosis

430 Patients Enrolled for Psychosis

Ontario Shores Centre for Mental Health SciencesOTHER

12 Previous Clinical Trials

2,118 Total Patients Enrolled

1 Trials studying Psychosis

360 Patients Enrolled for Psychosis

Michael W Best, Ph.D.Principal InvestigatorUniversity of Toronto

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are senior citizens eligible for enrollment in this research experiment?

"This research trial is accepting those aged 18 to 65."

Answered by AI

Are there still opportunities to join this scientific investigation?

"According to clinicaltrials.gov, the recruiting phase of this trial is ongoing; it was initiated on February 1st 2023 and most recently updated on January 19th 2023."

Answered by AI

To whom is this clinical trial open?

"This clinical trial seeks 20 patients with psychosis, aged between 18 and 65. Those eligible must have been diagnosed with schizophrenia, schizoaffective disorder or a related psychotic affliction; not be abusing any drugs or alcohol; possess the ability to read and converse in English; and exhibit active symptoms of psychosis as determined by PANSS measurements."

Answered by AI

What is the enrollment limit for this scientific investigation?

"Affirmative. The clinicaltrials.gov website documented that this trial, which was first published on February 1st of 2023, is currently searching for participants. Specifically, the study seeks to enroll 20 patients from a singular site."

Answered by AI

Recent research and studies

Schizophrenia ResearchJournal

The Effects of Individually Tailored Formulation-based Cognitive Behavioural Therapy in Auditory Hallucinations and Delusions: A Meta-analysis

van der Gaag, Mark, Lucia R. Valmaggia, and Filip Smit. 2014. “The Effects of Individually Tailored Formulation-based Cognitive Behavioural Therapy in Auditory Hallucinations and Delusions: A Meta-analysis”. Schizophrenia Research. Elsevier BV. doi:10.1016/j.schres.2014.03.016.

Archives of General PsychiatryJournal

Randomized Trial to Evaluate the Efficacy of Cognitive Therapy for Low-functioning Patients with Schizophrenia

Grant, Paul M.. 2012. “Randomized Trial to Evaluate the Efficacy of Cognitive Therapy for Low-functioning Patients with Schizophrenia”. Archives of General Psychiatry. American Medical Association (AMA). doi:10.1001/archgenpsychiatry.2011.129.

American Journal of PsychiatryJournal

The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and Validity

Nuechterlein, Keith H., Ph.D., Michael F. Green Ph.D., Robert S. Kern Ph.D., Lyle E. Baade Ph.D., Deanna M. Barch Ph.D., Jonathan D. Cohen M.D., Ph.D, Susan Essock Ph.D., et al.. 2008. “The MATRICS Consensus Cognitive Battery, Part 1: Test Selection, Reliability, and Validity”. American Journal of Psychiatry. American Psychiatric Association Publishing. doi:10.1176/appi.ajp.2007.07010042.

clinicaltrials.govStudy