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Vein Expansion Techniques for High Blood Pressure (OH Trial)
N/A
Recruiting
Led By Jian Cui
Research Sponsored by Milton S. Hershey Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Are 18 years of age
Are capable of giving informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up recorded continuously during visit 2, the 4-5 hr negative pressure study visit.
Awards & highlights
OH Trial Summary
This trial is testing whether expanding veins in the legs will lead to an increase in blood pressure.
Who is the study for?
This trial is for adults over 18 who can consent and speak English. It's for those with a specific type of high blood pressure that increases when standing, or normal blood pressure individuals matched by gender, age, and body size to the first group. Pregnant women, smokers, people with chronic diseases other than stage I hypertension, or history of blood clots are excluded.Check my eligibility
What is being tested?
The study tests if leg vein distension affects blood pressure during changes in posture. Participants will experience limb occlusion (blocking blood flow) with or without negative pressure and tilting with or without external pressure to simulate these conditions.See study design
What are the potential side effects?
Possible side effects may include discomfort from limb occlusion and changes in posture like dizziness due to shifts in blood pressure. However, detailed side effects aren't provided as this study focuses on physiological responses rather than drug interventions.
OH Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
I understand the study and can agree to participate.
OH Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ recorded continuously during visit 2, the 4-5 hr negative pressure study visit.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~recorded continuously during visit 2, the 4-5 hr negative pressure study visit.
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Muscle Tissue
Secondary outcome measures
Blood pressure in mmHg
Heart rate in beats per minute
OH Trial Design
4Treatment groups
Experimental Treatment
Placebo Group
Group I: Tilt + external pressureExperimental Treatment1 Intervention
Tilt + external pressure on legs performed in both "BP elevated with standing" and "BP maintained with standing" groups.
Group II: Limb occlusion + negative pressureExperimental Treatment1 Intervention
Limb occlusion + negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups.
Group III: Tilt + no external pressurePlacebo Group1 Intervention
Tilt + no external pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups.
Group IV: Limb occlusion + no negative pressurePlacebo Group1 Intervention
Limb occlusion + no negative pressure performed in both "BP elevated with standing" and "BP maintained with standing" groups.
Find a Location
Who is running the clinical trial?
Milton S. Hershey Medical CenterLead Sponsor
494 Previous Clinical Trials
2,798,812 Total Patients Enrolled
Jian CuiPrincipal InvestigatorPenn State College of Medicine
1 Previous Clinical Trials
32 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have had blood clots in the past.My blood pressure stays almost the same when I stand up, and I'm healthy with no chronic conditions.I am 18 years old or older.I understand the study and can agree to participate.I am under 18 years old.My blood pressure increases by at least 10 mmHg when I stand up, and I may have stage I hypertension without other chronic diseases.You currently smoke cigarettes.I have a chronic disease, but not stage I hypertension.I have low blood pressure when standing or a history of fainting.
Research Study Groups:
This trial has the following groups:- Group 1: Tilt + external pressure
- Group 2: Tilt + no external pressure
- Group 3: Limb occlusion + negative pressure
- Group 4: Limb occlusion + no negative pressure
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is registration for this trial currently open to the public?
"Correct. Per clinicaltrials.gov, this research endeavour is accepting participants and was first uploaded on March 10th 2020 before being updated the latest time on May 18th 2022."
Answered by AI
What is the total number of participants in this clinical investigation?
"Absolutely. According to the published information on clinicaltrials.gov, this study is in need of volunteers. The first posting was made on March 10th 2020 and it has been updated as recently as May 18th 2022. 30 participants are required at one medical institution for this research trial."
Answered by AI
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